Exploring hepatic stellate cell-driven fibrosis: therapeutic advances and future perspectives [0.03%]
探究肝星状细胞介导的肝纤维化：治疗进展与未来展望
Alka Singh,Ansab Akhtar,Prashant Shukla
Alka Singh
Background and purpose: Liver fibrosis, a progressive liver disease arising from viral or metabolic causes, poses a major global health challenge due to its potential progression to cirrhosis and hepatocellular carcinoma....
Comparison of lipophilic and size-exclusion membranes: the effect of stirring and cyclodextrin in the donor compartment [0.03%]
脂溶性和分子排阻性屏障比较：供试液的搅拌及环糊精的影响
Petra Tőzsér,Szabina Kádár,Edina Szabó et al.
Petra Tőzsér et al.
Background and purpose: The effective transport of an active pharmaceutical ingredient across various membrane systems is critical for enhancing its bioavailability, especially in formulations involving solubilizing agent...
Nano-modified biosensors for detection of pathogenic diseases: The prospect of smart, multiplex and point-of-care testing [0.03%]
用于检测致病疾病的纳米修饰生物传感器：智能、多重和现场护理测试的前景
Abdullahi Umar Ibrahim,Pwadubashiyi Coston Pwavodi,Mehmet Oszoz et al.
Abdullahi Umar Ibrahim et al.
Introduction and background: The world has witnessed several outbreaks, emergence and re-emergence of infectious diseases throughout the 21st century as a result of climate change, urbanization and migration. Several infe...
Monolayer graphene/platinum-modified 3D origami microfluidic paper-based biosensor for smartphone-assisted biomarkers detection [0.03%]
单层石墨烯/铂修饰的三维折纸微流控试纸型生物传感器用于智能手机辅助生物标志物检测
Arda Fridua Putra,Annisa Septyana Ningrum,Suyanto et al.
Arda Fridua Putra et al.
Background and purpose: Imbalances in biomarkers such as dopamine and NADH are linked to neurological and metabolic disorders, including Parkinson's disease, depression, and stroke, underscoring the need for rapid and acc...
Metabolic insights into the warfarin-mango interaction: A pilot study integrating clinical observations and metabolomics [0.03%]
基于临床观察和代谢组学的warfarin与芒果相互作用的代谢研究试点研究
Piyapat Rattanasuwan,Prem Lertpongpipat,Natthapat Hiranchatchawal et al.
Piyapat Rattanasuwan et al.
Background and purpose: Warfarin is a widely prescribed oral anticoagulant for the prevention and treatment of thromboembolic events, frequently used in patients with atrial fibrillation. However, its effectiveness is oft...
Correlation between A3243G and G9053A mtDNA mutations and ATP levels in diabetes mellitus patients using qPCR and electrochemical aptasensors [0.03%]
基于qPCR和电化学适配子传感器的糖尿病患者线粒体DNA A3243G和G9053A突变与ATP水平相关性研究
Iman Permana Maksum,Rahmaniar Mulyani,Yeni Wahyuni Hartati et al.
Iman Permana Maksum et al.
Background and purpose: Mitochondrial DNA (mtDNA) mutations can impair oxidative phosphorylation and ATP production, potentially contributing to the pathogenesis of type 2 diabetes mellitus (T2DM). This study aimed to inv...
Rapid detection of illegal selective androgen receptor modulators in unregistered supplements using a combination of selected solid-state analytical methods [0.03%]
基于固相筛选的分析方法快速检测补充剂中非法选择性雄激素受体调节剂
Izabela Jendrzejewska,Lubos Cehlarik,Tomasz Goryczka et al.
Izabela Jendrzejewska et al.
Background and purpose: Pharmaceutical crime is becoming an increasingly serious threat. For customs officers and police officers, minimal or no sample preparation before analysis is essential when detecting prohibited co...
Effect of surfactants and polymer composition on the characteristics of polyhydroxyalkanoate nanoparticles [0.03%]
表面活性剂和聚合物组成对聚羟基烷酸酯纳米粒子特性的影响
Aleksei Dorokhin,Sergei Lipaikin,Galina Ryltseva et al.
Aleksei Dorokhin et al.
Background and purpose: Polyhydroxyalkanoates (PHAs) are biodegradable polyesters of bacterial origin that are actively studied as matrices for the preparation of nanoparticulate drug delivery systems. The most significan...
Epirubicin-sensitive detection with a CoWO4/reduced graphene oxide modified screen-printed electrode [0.03%]
钴钨氧化物/还原型石墨烯复合材料修饰电极的表阿霉素检测方法研究
Somayeh Tajik,Razieh Moghimian,Hadi Beitollahi
Somayeh Tajik
Background and purpose: Because of its antimetabolic and cytotoxic qualities, epirubicin (EP), a crucial chemotherapeutic drug, has been used to treat a number of cancers, including those of the prostate, breast, ovary, s...
Targeting bone in cancer therapy: Advances and challenges of bisphosphonate-based drug delivery systems [0.03%]
靶向骨质的癌症治疗：以双膦酸盐为基础的药物传递系统的研究进展和挑战
Mohammadmahdi Eshaghi,Fariba Ganji,Hossein Shaki et al.
Mohammadmahdi Eshaghi et al.
Background and purpose: Bisphosphonates (BPs) are well-known for their strong affinity toward bone mineral matrices and are widely used to inhibit excessive osteoclast activity associated with various bone disorders. Beyo...