Pembrolizumab in PD-L1-positive advanced non-small cell lung carcinoma: A meta-analysis of survival benefits and immune-related toxicity events patterns [0.03%]
帕姆单抗治疗PD-L1阳性晚期非小细胞肺癌的生存效益和免疫相关毒副反应事件模式的meta分析
Alendra Chakramurty,Adetya Rahma Dinni,Ihda Silvia et al.
Alendra Chakramurty et al.
Background and objective: Pembrolizumab has shown significant therapeutic benefit in advanced non-small cell lung cancer (NSCLC), but it remains uncertain which patients will benefit the most, and recent data suggest that...
Topical composite hydrogel incorporating human amniotic membrane and spidroin for the treatment of chronic wounds in diabetes mellitus [0.03%]
人羊膜与蛛丝蛋白复合 topical 复合水凝胶治疗糖尿病慢性伤口
Suyarta Efrida Pakpahan,Anggraini Barlian,Arie Wibowo et al.
Suyarta Efrida Pakpahan et al.
Background and purpose: Traditional diabetic chronic skin wound dressings often lack the bioactivity required to promote regeneration in these complex wounds. The use of human amniotic membrane (hAM) has been identified a...
Comparison of lipophilic and size-exclusion membranes: creating sink conditions with cyclodextrin [0.03%]
脂溶性和分子筛膜的比较：使用环糊精创建消除条件
Petra Tőzsér,Szabina Kádár,Edina Szabó et al.
Petra Tőzsér et al.
Background and purpose: The effective transport of an active pharmaceutical ingredient across various membrane systems is critical for enhancing its bioavailability, especially in formulations involving solubilizing agent...
Epithelial-mesenchymal dynamics in cancer: Role of signalling pathways, stromal interactions and natural therapies [0.03%]
癌症上皮间质动态：信号通路、间质作用和天然疗法的作用
Iram Khan,Anindita Behera,Kamesh R Babu et al.
Iram Khan et al.
Background and purpose: Epithelial-mesenchymal transition (EMT) and its reverse process, mesenchymal-epithelial transition (MET), play crucial roles in embryogenesis, tissue regeneration, and cancer progression. Dysregula...
Advancing through the blood-brain barrier: mechanisms, challenges and drug delivery strategies [0.03%]
突破血脑屏障：机制、挑战及药物递送策略
Ronny Vargas,Noelia Martinez-Martinez,Catalina Lizano-Barrantes et al.
Ronny Vargas et al.
Background and purpose: The delivery of therapeutics to the central nervous system (CNS) remains a major challenge due to the restrictive nature of the blood-brain barrier (BBB), a key evolutionary feature that preserves ...
Lipid functionalized silver-coated carbon dot-capped manganese ferrite as drug-free core-shell nanoparticles for multimodal imaging and therapy [0.03%]
脂质功能化银层壳四氧化三铁@碳点核多功能影像与治疗体系
Anbazhagan Thirumalai,Pazhani Durgadevi,Venkatakrishnan Kiran et al.
Anbazhagan Thirumalai et al.
Background and purpose: Multifunctional nanoparticles (NPs) are gaining significant interest in biomedical research because of their versatility and potential across various applications, especially in cancer imaging and ...
Fabrication and optimization of freeze-dried isoniazid-loaded poly- ε-caprolactone nanoparticles [0.03%]
冷冻干燥异烟肼载药聚-ε-己内酯纳米粒的制备及优化
Eknath Kole,Yuvraj Pawara,Atul Chaudhari et al.
Eknath Kole et al.
Background: Microfluidic nanoprecipitation followed by freeze-drying would yield uniformly sized, stable nanoparticles by preserving their physicochemical property without compromising therapeutic performance. The isoniaz...
Morphine electrochemical determination using SnO2 nanostructure-modified glassy carbon electrode in the presence of diclofenac [0.03%]
对乙酰氨基酚存在下二氧化锡纳米结构修饰的玻璃碳电极用于吗啡的电化学生物测定法研究
Zainab S Hadawi,Isam Ngaimesh Taeb,Rasha N Aljabery
Zainab S Hadawi
In the present work, SnO2 nanostructures were synthesized and a sensitive voltammetric sensor on a glassy carbon electrode (GCE) was constructed to estimate morphine (MP) in the presence of diclofenac (DLF). ...
Mayu Konishi,Kiyohiko Sugano
Mayu Konishi
Background and purpose: Predicting the food effect on oral drug absorption by physiologically based biopharmaceutical modelling (PBBM) remains challenging. The bile micelle unbound fraction (f u) is one of the primary det...
Electrochemical sensors for anticancer drugs used in the targeted therapy of chronic myeloid leukaemia [0.03%]
用于慢性髓性白血病靶向治疗的抗肿瘤药物的电化学生物传感器
Totka Dodevska
Totka Dodevska
Background and purpose: Treatment of chronic myeloid leukaemia includes targeted therapy with tyrosine kinase inhibitors (TKIs): imatinib, dasatinib, nilotinib, bosutinib, ponatinib, and asciminib. This review aims to pro...