Electrochemical determination of calcium folinate in the presence of methotrexate and 5-fluorouracil using UiO-66/CdS composite modified screen-printed carbon electrode [0.03%]
基于UiO-66/CdS复合材料修饰的屏幕打印碳电极测定甲氨蝶呤和氟尿嘧啶存在下次钙叶酸含量
Fatma A Khazaal,Qasim Mezban Salih,Raad Radi Karabat et al.
Fatma A Khazaal et al.
Background and purpose: Calcium folinate is frequently co-administered with methotrexate and 5-fluorouracil in chemotherapeutic treatments to enhance therapeutic efficacy and reduce toxicity. Therefore, simple and accurat...
TiO2-embedded molecularly imprinted polymer as electrochemical sensor for ultrasensitive determination of glycopyrronium bromide [0.03%]
钛白嵌入电化学传感器检测溴化glycopyrronium超灵敏电化学传感器
Zehra Dogan,Ensar Piskin,Ahmet Cetinkaya et al.
Zehra Dogan et al.
Background and purpose: The precise quantification and quality evaluation of glycopyrronium bromide (GLB), a long-acting muscarinic antagonist widely used in the treatment of chronic obstructive pulmonary disease, require...
Y-Co metal-organic framework for sensitive electrochemical determination of doxorubicin hydrochloride [0.03%]
用于电化学测定盐酸多柔比星的Y-Co金属有机骨架材料研究
Somayeh Mir,Niloufar Akbarzadeh Torbati,Vahid Amani et al.
Somayeh Mir et al.
Background and purpose: Cancer represents a major challenge to public health; therefore, identifying doxorubicin hydrochloride (DOX·HCl) as an important chemotherapy drug holds considerable significance. ...
A simple UiO-66-NH2@MWCNTs based electrochemical sensor for the sensitive detection of metronidazole [0.03%]
一种简单的UiO-66-NH2@MWCNTs 基电化学传感器用于敏感检测甲硝唑
Noor Abd Alkhudhur Salman,Israa A Jassem,Isam Nghaimesh Taeb
Noor Abd Alkhudhur Salman
Background and purpose: Metronidazole (MRNZ) is a highly efficacious pharmacological agent for treating protozoal infections, including trichomoniasis, giardiasis, and disorders caused by anaerobic bacteria. ...
New xanthone and chemical constituents from the aerial parts of Mallotus glomerulatus and their cytotoxicity in MCF-7 and MDA-MB-231 breast cancer cells [0.03%]
毛菍地上部分中新黄酮及其抗乳腺癌细胞活性研究
Napason Chabang,Chanikarn Wongwitayasombat,Patoomratana Tuchinda et al.
Napason Chabang et al.
Background and purpose: Breast cancer remains a significant global health burden, especially in low-resource settings where standard therapies are limited. This study aimed to explore Mallotus glomerulatus, a lesser-known...
Nano-biomaterials in cancer therapy: Advances in targeting and overcoming cancer stem cell resistance [0.03%]
纳米生物材料在癌症治疗中的应用：针对并克服癌干细胞耐药性的新进展
Marzieh Dehghani,Behnam Hajipour-Verdom,Fatemeh Rahimzadeh et al.
Marzieh Dehghani et al.
Background and purpose: Cancer remains a leading cause of death globally, with long-term treatment success hindered by metastasis, recurrence, and therapy resistance. A central driver of these limitations is cancer stem c...
Interaction between albumin originating from persons with uncontrolled diabetes mellitus type 2 and food antioxidants [0.03%]
人II型未控制糖尿病来源的白蛋白与食物抗氧化剂之间的相互作用
Miloš Šunderić,Dragana Dekanski,Olgica Nedić
Miloš Šunderić
Background and purpose: Dietary interventions are a cornerstone in the management of type 2 diabetes mellitus. The efficiency, however, depends on pharmacokinetic factors, including the interaction of food ingredients wit...
Elucidating CYP2D6-driven metabolism and hepatotoxic bioactivation of metoprolol in plateable human and animal hepatocytes [0.03%]
基于CYP2D6的美托洛尔代谢及肝毒性激活的人和动物可培养肝细胞研究
Jiang Pu,Mei Yang,Min Zhang et al.
Jiang Pu et al.
Background and purpose: As a classic β-blocker with low systemic clearance, metoprolol has been linked to rare but clinically significant hepatotoxicity, yet its hepatic metabolic fate remains poorly characterized. ...
Prediction of metabolism and solubility of tablet-form drugs according to the biopharmaceutical drug disposition classification system [0.03%]
基于药代分类系统的口服药物代谢和溶解度的预测方法
Yaroslava Pushkarova,Galina Zaitseva,Kaouthar Bouaalam
Yaroslava Pushkarova
Background and purpose: Prediction of metabolism and solubility of tablet-form drugs is essential in pharmaceutical development, impacting drug efficacy, safety and formulation strategies. This study aimed to develop pred...
Development of a biorelevant dissolution method for inhalation products: Proof of concept using drugs with diverse solubilities [0.03%]
开发一种用于吸入产品的生物相关溶解度方法：使用不同溶解度的药物进行概念验证
Amar Elezović,Sandra Cvijić,Saša Pilipović et al.
Amar Elezović et al.
Background and purpose: Due to their unique application and action, inhalation products require specific quality tests, such as Uniformity of Delivered Dose and Aerodynamic Assessment of Fine Particles. While there's no c...