Sara Soriano-Meseguer,Elisabet Fuguet,Adriana Port et al.
Sara Soriano-Meseguer et al.
In recent years, the parallel artificial membrane permeability assay (PAMPA) has been extended for prediction of skin permeation by developing an artificial membrane which mimics the stratum corneum structure, skin-PAMPA. In the present wor...
Evaluation of pharmacokinetics of warfarin from validated pharmacokinetic-pharmacodynamic model [0.03%]
评价来自验证过的药动学-药效学模型的华法林药动学
Kannan Sridharan,Rashed Al Banna,Aysha Husain
Kannan Sridharan
Background: Pharmacokinetics of warfarin has not been described in our population. We derived the pharmacokinetic parameters from a validated pharmacokinetic-pharmacodynamic model. ...
Biomimetic properties and estimated in vivo distribution of chloroquine and hydroxy-chloroquine enantiomers [0.03%]
氯喹和羟氯喹对映体的类生物特性及其体内分布估算
Klara L Valko,Tong Zhang
Klara L Valko
Chloroquine and hydroxy-chloroquine already established as anti-malarial and lupus drugs have recently gained renewed attention in the fight against the Covid-19 pandemic. Bio-mimetic HPLC methods have been used to measure the protein and p...
Synthesis and biological activity of 2-[6-methyl-4-(thietan-3-yloxy)pyrimidin-2-ylthio]acetohydrazide derivatives [0.03%]
2-[6-甲基-4-(噻坦-3-氧基)嘧啶-2-基硫]乙酰胲衍生物的合成及其生物活性研究
Svetlana Meshcheryakova,Alina Shumadalova,Ozal Beylerli et al.
Svetlana Meshcheryakova et al.
The synthesis and antimicrobial evaluation of new 2-[6-methyl-4-(thietan-3-yloxy)pyrimidin-2-ylthio]acetohydrazide derivatives was investigated. According to the literature, there are a lot of antimicrobial agents among the pyrimidines and ...
Kiyohiko Sugano
Kiyohiko Sugano
Over the past few decades, physiologically-based pharmacokinetic modelling (PBPK) has been anticipated to be a powerful tool to improve the productivity of drug discovery and development. However, recently, multiple systematic evaluation st...
Ronny Vargas,Andrea Egurbide-Sifre,Laura Medina
Ronny Vargas
Research on alternatives to the use of animal models and cell cultures has led to the creation of organ-on-a-chip systems, in which organs and their physiological reactions to the presence of external stimuli are simulated. These systems co...
Expression and Transport of α-Synuclein at the Blood-Cerebrospinal Fluid Barrier and Effects of Manganese Exposure [0.03%]
α-突触核蛋白在血脑脊液屏障中的表达、转运及锰暴露的影响
Christopher A Bates,Sherleen Fu,Daniel Ysselstein et al.
Christopher A Bates et al.
The choroid plexus maintains the homeostasis of critical molecules in the brain by regulating their transport between the blood and cerebrospinal fluid (CSF). The current study was designed to investigate the potential role of the blood-CSF...