Characterization of biosurfactants' micelles formation using fluorescence measurements: sodium taurocholate as case of study [0.03%]
采用荧光测量表征生物表面活性剂胶束的形成：以牛磺胆酸钠为例研究
Susana Amézqueta,Elisabet Fuguet,Rubén Cabañas et al.
Susana Amézqueta et al.
Background and purpose: The evaluation of micellization parameters of surfactants that aggregate gradually, such as bile salts, is not trivial. In this work, different probes and data treatment models are tested to set up...
Ex vivo propofol permeation across nasal mucosa: A proof-of-concept study for outpatient light sedation via nasal route [0.03%]
体外丙泊酚鼻粘膜渗透性：门诊轻度镇静给药的新方法
Michele D Spampinato,Anna Costanzini,Roberto De Giorgio et al.
Michele D Spampinato et al.
Background and purpose: Aiming to achieve light sedation via intranasal administration, this study showed that propofol (PPF) did not permeate across the rabbit nasal mucosa ex vivo from its marketed emulsion for injectio...
Molecular properties, including chameleonicity, as essential tools for designing the next generation of oral beyond rule of five drugs [0.03%]
包括变色龙特性在内的分子属性作为设计下一代口服超越五规则药物的必不可少工具
Diego García Jiménez,Maura Vallaro,Luigi Vitagliano et al.
Diego García Jiménez et al.
Background and purpose: The classical drug discovery toolbox continually expands beyond traditional rule of five (Ro5)-compliant small molecules to include new chemical modalities for difficult-to-drug targets. The paper ...
What matters for drug delivery to tumor by nanoparticles: Gaining insights from PBPK/PD simulation of drug nanocrystals [0.03%]
基于药物纳米晶体的PBPK/PD仿真探讨肿瘤给药的要素
Shan Lu,Clairissa D Corpstein,Kinam Park et al.
Shan Lu et al.
Background and purpose: In our previous studies, drug nanocrystals were directly prepared by solution crystallization, possessing uniform particle size and morphology suitable for intravenous (IV) injection. These nanocry...
Predicting the acute aquatic toxicity of organic UV filters used in cosmetic formulations [0.03%]
预测用于化妆品配方的有机紫外线过滤剂的急性水生毒性
Chrysanthos Stergiopoulos,Fotios Tsopelas,Maria Ochsenkühn-Petropoulou et al.
Chrysanthos Stergiopoulos et al.
Background and purpose: Organic UV filters are commonly used in sunscreen and cosmetic formulations to protect against harmful UV radiation. However, concerns have emerged over their potential toxic effects on aquatic org...
Modelling of chromatographic and electrophoretic behaviour of imidazoline and alpha adrenergic receptors ligands under different acid-base conditions [0.03%]
不同酸碱条件下咪唑啉和α肾上腺素受体配体色谱及电泳行为的模拟研究
Slavica Oljacic,Mitja Križman,Marija Popovic-Nikolic et al.
Slavica Oljacic et al.
Background and purpose: The ligands of the imidazoline and α-adrenergic receptors are mainly imidazoline and guanidine derivatives, known as centrally-acting antihypertensives and compounds with potential use in various ...
María I León-Campos,Juan J Mendoza,Hilda Aguayo-Morales et al.
María I León-Campos et al.
Background and purpose: Interpenetrating polymer network (IPN) hydrogels are an adaptable category of materials, exhibiting remarkable promise for various biological applications due to their distinctive structural and fu...
Cerium oxide nanoparticles-assisted aptasensor for chronic myeloid leukaemia detection [0.03%]
用于慢性髓性白血病检测的氧化铈纳米粒子免疫传感器
Yuspian Nur,Muhammad Ihda Hl Zein,Irkham Irkham et al.
Yuspian Nur et al.
Background and purpose: Chronic myeloid leukaemia (CML) is one of the most lethal types of leukaemia and can rapidly progress if not treated properly. Therefore, having an effective diagnostic strategy is crucial. Various...
Determination of methotrexate using carbon paste electrode modified with ionic liquid/Ni-Co layered double hydroxide nanosheets as a voltammetric sensor [0.03%]
一种用于伏安传感器的碳糊电极测定甲氨蝶呤离子液体/镍-钴层状双氢氧化物纳米片改性方法
Peyman Mohammadzadeh Jahani,Fariba Garkani Nejad,Reza Zaimbashi et al.
Peyman Mohammadzadeh Jahani et al.
Background and purpose: Methotrexate (MTX) is a widely used anti-cancer drug, but its overuse can lead to significant side effects. Therefore, it is very vital to design simple and sensitive analytical methods for its det...
Analgesic effects of intraarticular anaesthetic lidocaine and methylprednisolone versus methylprednisolone alone following knee arthroscopy [0.03%]
术后膝关节镜检查时玻璃酸钠与单纯甲泼尼龙疗效的对照研究
Wahid Mohammed Hassan,Anas Amer Mohammad
Wahid Mohammed Hassan
Background: Knee arthroscopy is a widely practiced orthopaedic procedure known for its minimally invasive approach, allowing quicker recovery times and less postoperative discomfort than traditional open surgeries. Howeve...