Determination of remifentanil in neonatal dried blood spots by liquid chromatography-tandem mass spectrometry [0.03%]
液相色谱-串联质谱法测定新生儿干血斑中的瑞米芬太尼
Jurij Trontelj,Aleš Rozman,Aleš Mrhar
Jurij Trontelj
Remifentanil is an ultra-short-acting synthetic opioid-class analgesic which might be increasingly used "off-label" as pain management during labour. Side effects in parturients during labour, and in the infant at birth are of particular co...
Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L [0.03%]
Cistus albidus L.的化学成分及潜在抗氧化、抗炎和镇痛功效研究
Aziz Zouhri,Toufik Bouddine,Naoual El Menyiy et al.
Aziz Zouhri et al.
This study aims to assess the chemical composition of the aqueous extract of Cistus albidus L. leaves, as well as the potential of aqueous and hydroethanol extracts of the leaves and seeds as analgesic, anti--inflammatory, and antioxidant a...
Medicarpin suppresses lung cancer cell growth in vitro and in vivo by inducing cell apoptosis [0.03%]
Medicarpin通过诱导细胞凋亡抑制体外和体内肺癌细胞增殖
Zongyi Shen,Liqi Yin,Manxia Chang et al.
Zongyi Shen et al.
Lung cancer (LC) is the leading cause of cancer deaths worldwide. Surgery, chemoradiotherapy, targeted therapy, and immunotherapy are considered dominant treatment strategies for LC in the clinic. However, drug resistance and meta-stasis ar...
Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway [0.03%]
Deguelin通过诱导凋亡和G2 / M细胞周期阻滞抑制人多发性骨髓瘤细胞的增殖：Akt和p38 MAPK信号通路的参与
Kening Sun,Ping Chen,Liang Zhang et al.
Kening Sun et al.
Deguelin exhibits antiproliferative activity against various cancer cell types. Previous studies have reported that deguelin exhibits pro-apoptotic activity against human cancer cells. The current study aimed at further elaborating the anti...
A comprehensive overview of selective and novel fibroblast growth factor receptor inhibitors as a potential anticancer modality [0.03%]
一种新型的及选择性的成纤维细胞生长因子受体抑制剂作为潜在抗肿瘤手段的全面概述
Nem Kumar Jain,Mukul Tailang,Neelaveni Thangavel et al.
Nem Kumar Jain et al.
The arrival of comprehensive genome sequencing has accelerated the understanding of genetically aberrant advanced cancers and target identification for possible cancer treatment. Fibroblast growth factor receptor (FGFR) gene alterations are...
Long non-coding RNA TINCR suppresses growth and epithelial-mesenchymal transition by inhibiting Wnt/ β-catenin signaling pathway in human pancreatic cancer PANC-1 cells: Insights from in vitro and in vivo studies [0.03%]
长非编码RNA TINCR通过抑制Wnt/β-catenin信号通路抑制人胰腺癌PANC-1细胞的增殖和上皮间质转化：体内外研究的新发现
Yuan Wei,Ping Zhu
Yuan Wei
There is increasing evidence that long non-coding RNAs (lncRNAs) play a crucial role in the development and progression of malignant tumors, particularly pancreatic cancer. In this study, the influence of the lncRNA TINCR on the behavior of...
Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model [0.03%]
普伐他汀和罗苏伐他汀对糖尿病大鼠糖代谢影响的比较研究
Hacer Kayhan Kaya,Berjan Demirtas,Beran Yokus et al.
Hacer Kayhan Kaya et al.
Statin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully ...
Novel (±)- trans- β-lactam ureas: Synthesis, in silico and in vitro biological profiling [0.03%]
新型(±)-trans-β-内酰胺脲类化合物：合成与体外生物活性研究
Mladenka Jurin,Višnja Stepanić,Krunoslav Bojanić et al.
Mladenka Jurin et al.
A diastereomeric mixture of racemic 3-phthalimido-b-lactam 2a/2b was synthesized by the Staudinger reaction of carboxylic acid activated with 2-chloro-1-methylpyridinium iodide and imine 1. The amino group at the C3 position of the b-lactam...
Furanocoumarin compounds isolated from Dorstenia foetida potentiate irinotecan anticancer activity against colorectal cancer cells [0.03%]
从Dorstenia foetida中分离的呋喃香豆素化合物可增强鸢尾素的抗癌活性以对抗结直肠癌细胞
Supusson Pengnam,Watcharapa Jitkaroon,Roongtiwa Srisuphan et al.
Supusson Pengnam et al.
Although the anticancer activity of Dorstenia foetida was already observed, the chemical entity responsible for this activity remained unidentified. In this study, the cytotoxic activity of two furanocoumarin compounds, i.e., 5-methoxy--3-(...
Characterization of mineral composition of leaves and flowers of wild-growing Sambucus nigra [0.03%]
野生长在的桑巴库斯尼格拉叶和花的矿物成分特征分析
Bujar Qazimi,Trajče Stafilov,Katerina Bačeva Andonovska et al.
Bujar Qazimi et al.
The objective of this study was to determine the mineral content in the leaves and flowers of wild-grown Sambucus nigra collected from eleven different locations in Kosovo. The samples were digested in a microwave system using the wet diges...