Electron paramagnetic resonance studies of free radicals: The research legacy of Janko N. Herak [0.03%]
电子顺磁共振自由基研究：Janko N.Herak的研究成果及其影响
Erim Bešić,Valerije Vrček,Davor Šakić
Erim Bešić
This review presents a chronological analysis of the scientific contributions of Professor Janko N. Herak (1937-2025), a Croatian biophysicist whose research played a major role in the development of electron para-magnetic resonance (EPR) s...
Synergistic effect of piperine combined with luteolin on anti-non-small cell lung cancer activity in vitro and in LLC tumour-bearing mice: Mechanistic insights from network pharmacology and molecular docking [0.03%]
胡椒碱联合木犀草素抗非小细胞肺癌的协同作用及机制研究：网络药理学和分子对接分析
Liangfeng Wang,Yuexing Chang,Yufeng Liu et al.
Liangfeng Wang et al.
Piperine had synergistic effects with other natural products in treating lung cancer. The synergistic effects of piperine combined with luteolin on anti-non-small cell lung cancer activity and their mechanism of action are studied using net...
Targeting atherosclerotic inflammation: Advances in NLRP3 inflammasome inhibitors beyond LDL-C [0.03%]
靶向动脉粥样硬化炎症： LDL-C以外的NLRP3炎性小体抑制剂研究进展
Ligang Bao,Xialing Dai
Ligang Bao
Atherosclerosis, the main pathological background of cardiovascular diseases, is not only characterized by lipid metabolism disorders but also chronic inflammation as a major driver of disease progression. As a key regulator of inflammatory...
Recurrent urinary tract infections in older adults: A systematic review of current challenges and emerging therapeutic strategies [0.03%]
老年人反复发作的泌尿系感染：当前面临的挑战及新兴治疗策略系统的回顾
Junmei Lv,Ajaz Ahmad Waza
Junmei Lv
As global life expectancy continues to rise, urinary tract infections (UTIs) have become an increasing concern in older adults. The higher prevalence in this population is attributed to anatomical and physiological changes of the urinary tr...
SEM/EDS analysis as a complementary tool for continuous improvement of cefixime granules for oral suspension [0.03%]
扫描电子显微镜/能量色散光谱分析在头孢克肟颗粒（口服）持续改善中的辅助作用研究
Ivana Mitrevska,Dino Karpicarov,Ana Mihailovska et al.
Ivana Mitrevska et al.
The aim of this study was to evaluate scanning electron microscopy (SEM) combined with energy-dispersive X-ray spectroscopy (EDS) as complementary analytical tools for supporting continuous improvement in pharmaceutical granule manufacturin...
β-Carboline and chloroquine hybrids as potent antiplasmodial agents: Design, synthesis and biological evaluation [0.03%]
设计、合成及生物活性评价具有较强的抗疟活性的β-咔啉与氯喹杂合化合物
Ana Penava,Lais Pessanha De Carvalho,Jana Held et al.
Ana Penava et al.
A series of thirteen novel β-carboline and chloroquine (CQ) hybrids was designed and synthesized. The compounds were evaluated for in vitro antiplasmodial activity against Plasmodium falciparum strains 3D7 (CQ-sensitive) and Dd2 (multidrug...
Freeze-dried kit formulation and physicochemical assessment of a daratumumab-based radiopharmaceutical [0.03%]
达雷木单抗放射药的冻干制剂及理化性质评估
Paulina Apostolova,Marija Atanasova Lazareva,Katarina Davalieva et al.
Paulina Apostolova et al.
Daratumumab is a fully human anti-CD38 monoclonal antibody with strong potential as a targeting vector for therapeutic radionuclides. This study aimed to develop a freeze-dried daratumumab immunoconjugate kit by selecting a suitable chelato...
Li Zechen
Li Zechen
Deep eutectic solvents (DESs) have garnered significant attention in pharmaceutical research in recent years due to their high efficiency, facile separability and biocompatibility. Characterised by hydrogen-bond donors (HBDs) and hydrogen-b...
Pelargonidin protects retinal ganglion cells in a streptozotocin-induced diabetic rat model by reducing intraocular pressure, suppressing TGF-β and activating JAK2/STAT3 signalling pathway [0.03%]
茋红素通过降低眼内压、抑制TGF-β和激活JAK2/STAT3信号通路保护糖尿病大鼠模型视网膜神经节细胞
Haichun Yu,Ashraf Albrakati,Ejaz Akbar Wani et al.
Haichun Yu et al.
Diabetic retinopathy (DR) is one of the primary causes of vision impairment, affecting individuals with diabetes, and is marked by the neurodegeneration of the retina along with increased intraocular pressure (IOP). This study sought to det...
Beneficial effect of omega-3 fatty acids supplementation on leaky gut, inflammation and oxidative stress in propionic acid-induced autism in aged rats [0.03%]
ω-3脂肪酸对丙酸根诱导的年老鼠自闭症肠漏、炎症和氧化应激的有益作用
Amal Aloud,Hayat Alzahrani,Shaista Arzoo et al.
Amal Aloud et al.
This study examined the effects of omega-3 fatty acids supplementation on gut barrier integrity, systemic inflammation, neurotrans-mission and oxidative stress, in an aged rat model of propionic acid (PPA)-induced neurotoxicity. Twenty-four...