Pelargonidin protects retinal ganglion cells in a streptozotocin-induced diabetic rat model by reducing intraocular pressure, suppressing TGF-β and activating JAK2/STAT3 signalling pathway [0.03%]
Haichun Yu,Ashraf Albrakati,Ejaz Akbar Wani et al.
Haichun Yu et al.
Diabetic retinopathy (DR) is one of the primary causes of vision impairment, affecting individuals with diabetes, and is marked by the neurodegeneration of the retina along with increased intraocular pressure (IOP). This study sought to det...
Beneficial effect of omega-3 fatty acids supplementation on leaky gut, inflammation and oxidative stress in propionic acid-induced autism in aged rats [0.03%]
ω-3脂肪酸对丙酸根诱导的年老鼠自闭症肠漏、炎症和氧化应激的有益作用
Amal Aloud,Hayat Alzahrani,Shaista Arzoo et al.
Amal Aloud et al.
This study examined the effects of omega-3 fatty acids supplementation on gut barrier integrity, systemic inflammation, neurotrans-mission and oxidative stress, in an aged rat model of propionic acid (PPA)-induced neurotoxicity. Twenty-four...
The effect of astragaloside IV on a model of isoproterenol-induced hypertrophic injury in H9c2 cells [0.03%]
黄芪皂苷IV对异丙肾上腺素诱导的H9c2心肌细胞肥大损伤模型的影响
Yang Long,Yuan Xiao,Chun Chen et al.
Yang Long et al.
The objective of this study was to explore the protective effect of astragaloside IV on a model of isoproterenol-induced (ISO) hyper-trophic injury in rat cardiomyocytes H9c2 (cell line derived from embryonic BD1X rat heart tissue). A cell ...
H3 relaxin mediated neuroprotection in Alzheimer's disease pathology induced by streptozotocin in mouse models: Impact on memory improvement, autophagy and PI3K/Akt-mTOR signalling pathway [0.03%]
Relaxin H3在链脲佐菌素诱导的小鼠阿尔茨海默病模型中的神经保护作用：对记忆改善、自噬和PI3K / Akt-mTOR信号通路的影响
Huiyu Zhao,Yuhong Sun,Shaik Althaf Hussain et al.
Huiyu Zhao et al.
Alzheimer's disease (AD) is characterised by β-amyloid (Aβ) plaque accumulation and tau hyperphosphorylation. H3 relaxin, a neuro-peptide, is known to exert neuroprotective effects. In this study, we investigated how H3 relaxin confers ne...
Sexually dimorphic and time-dependent influence of active avoidance learning by vilazodone in C57BL/6J mice [0.03%]
Vilazodone伏西硝平对C57BL/6J小鼠主动回避学习的性别差异和时间依赖性影响
Kang Hu,Anran Zhang,Yuan Shi et al.
Kang Hu et al.
The effects of vilazodone (VZD) on the acquisition of active avoidance behavior were examined in C57BL/6J mice. Both female and male mice were assigned to three groups (n = 8 per group per sex): the vehicle control group (VEH), the 0.5 mg k...
Predictive analytical workflow for rapid structure elucidation and in silico toxicological qualification of an unidentified impurity in cefixime granules for oral suspension [0.03%]
头孢克肟颗粒中未知杂质的结构解析及毒理学评价的预测分析流程研究
Ivana Mitrevska,Marina Chachorovska,Gjorgji Petrushevski
Ivana Mitrevska
During in-use stability testing of cefixime granules for oral suspension, an impurity with a relative retention time of 0.19 was consistently detected and increased during storage. To ensure regulatory compliance and patient safety, the imp...
Antibacterial and antibiofilm activities of naturally occurring naphthoquinones 2-hydroxy-1,4-naphthoquinone and 2-methoxy-1,4-naphthoquinone against Escherichia coli [0.03%]
天然产物菲醌2-羟基-1,4-菲醌和2-甲氧基-1,4-菲醌对大肠杆菌的抗菌和抗生物被膜活性
Darija Stupin Polančec,Dafinë Kastrati Bajçinca,Ana-Marija Domijan
Darija Stupin Polančec
The aim of this study was to evaluate the antibacterial and antibio-film potential of two naturally occurring naphthoquinones, 2-hydroxy-1,4-naphthoquinone (2-HNQ) and 2-methoxy-1,4-naphthoquinone (2-MNQ), against the Gram-negative bacteriu...
Motility, biofilm, and endotoxin in Ralstonia pickettii isolates obtained from purified and ultrapure pharmaceutical water systems [0.03%]
不动性、生物被膜和内毒素的产生在来源于注射用水和纯蒸汽制药水系统的伯克霍尔德氏菌中的分布研究
Ivanka Batarilo,Branka Bedenić,Mia Slade-Vitković et al.
Ivanka Batarilo et al.
This study aimed to examine the motility, biofilm production, endotoxin release, and antibiotic resistance of 81 Ralstonia pickettii isolates collected from different pharmaceutical water systems in Croatia. Swimming and twitching motility ...
Application of green analytical principles in the HPLC analysis of prednisolone derivatives: Method optimization and validation for nasal powder formulations [0.03%]
绿色分析原理在HPLC测定皮质激素鼻粉剂中应用及方法学研究
Daniela Amidžić Klarić,Jelena Kovačić,Ilija Klarić et al.
Daniela Amidžić Klarić et al.
Glucocorticoids are a group of drugs increasingly used in modern medical practice due to their pronounced anti--inflammatory and immunosuppressive properties. In this study, prednisolone disodium phosphate and prednisolone acetate were anal...
Double-blind randomised controlled trial of an emollient cream with and without 1 % supercritical CO2 extract of Calendula officinalis in contact dermatitis [0.03%]
含1%Calendula officinalis超临界CO₂萃取物的润肤霜治疗接触性皮炎的双盲随机对照试验
Mia Šušak Crnčević,Toni Durdov,Doris Rušić et al.
Mia Šušak Crnčević et al.
This double-blind randomised controlled trial aimed to evaluate the efficacy of an emollient cream with and without 1 % supercritical CO2 extract of Calendula officinalis in contact dermatitis. Twenty healthy volunteers without pre-existing...
Randomized Controlled Trial
Acta pharmaceutica (Zagreb, Croatia). 2026 Jan 13;75(4):699-708. DOI:10.2478/acph-2025-0035 2026