Tannic acid elicits differential gene regulation in prostate cancer apoptosis [0.03%]
棓酸誘導前列腺癌細胞凋亡之相關基因調控研究
Sinan Kandir,Sevtap Karakurt,Çiğdem Gökçek-Saraç et al.
Sinan Kandir et al.
Prostate cancer is a significant global health concern that requires innovative therapeutic investigations. Here, the potential anticancer properties of tannic acid were evaluated by examining its effects on apoptosis in prostate cancer cel...
Lipid-based systems with precipitation inhibitors as formulation approach to improve the drug bioavailability and/or lower its dose: a review [0.03%]
脂质系统与沉淀抑制剂的药物递送策略改善生物利用度及降低给药剂量的研究进展综述
Mila Kovačević,Mirjana Gašperlin,Alenka Zvonar Pobirk
Mila Kovačević
Lipid-based systems, such as self-microemulsifying systems (SMEDDS) are attracting strong attention as a formulation approach to improve the bioavailability of poorly water-soluble drugs. By applying the "spring and parachute" strategy in d...
Lyophilised protein formulations as a patient-centric dosage form: A contribution toward sustainability paradigm [0.03%]
以患者为中心的给药形式：迈向可持续发展模式的冷冻干燥蛋白制剂
Maja Bjelošević Žiberna,Pegi Ahlin Grabnar,Mirjana Gašperlin et al.
Maja Bjelošević Žiberna et al.
At present, society has embraced the fact apropos population aging and climate changes, that demand, amongst others, innovative pharmaceutical technologies, emphasising the development of patient-specific delivery systems and thus the provi...
The potential of three-dimensional printing for pediatric oral solid dosage forms [0.03%]
三维打印在儿科固体口服制剂中的应用前景
Klemen Kreft,Marina Fanous,Volker Möckel
Klemen Kreft
Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compoundi...
Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function [0.03%]
大麻籽或亚麻籽油基液晶的临床应用：其对皮肤屏障功能影响的评估
Mercedes Vitek,Mirjam Gosenca Matjaž
Mercedes Vitek
The principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for the development of skin diseases such as atopic dermatitis (AD), which is the...
Randomized Controlled Trial
Acta pharmaceutica (Zagreb, Croatia). 2024 May 30;74(2):301-313. DOI:10.2478/acph-2024-0014 2024
Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy [0.03%]
斯洛文尼亚十年来老年人镇静和抗胆碱能药物负担的变化趋势及其潜在的用药优化空间
Janja Jazbar,Igor Locatelli,Mitja Kos
Janja Jazbar
This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization ...
Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs [0.03%]
以难溶性药物为重点的多单元释药系统掩味技术综述与展望
Tilen Simšič,Odon Planinšek,Ana Baumgartner
Tilen Simšič
In the past, the administration of medicines for children mainly involved changes to adult dosage forms, such as crushing tablets or opening capsules. However, these methods often led to inconsistent dosing, resulting in under- or overdosin...
Nuša Japelj,Nejc Horvat,Lea Knez et al.
Nuša Japelj et al.
This umbrella review examined systematic reviews of deprescribing studies by characteristics of intervention, population, medicine, and setting. Clinical and humanistic outcomes, barriers and facilitators, and tools for deprescribing are pr...
Population pharmacokinetics of ramipril in patients with chronic heart failure: A real-world longitudinal study [0.03%]
基于真实世界队列的心力衰竭患者雷米普利药代动力学研究
Katja Čvan Trobec,Iztok Grabnar,Jurij Trontelj et al.
Katja Čvan Trobec et al.
In patients with chronic heart failure (CHF), the use of angiotensin-converting enzyme inhibitors, including ramipril, is recommended to reduce the risk of heart failure worsening, hospitalisation, and death. Our aim was to investigate the ...
Forecasting the effect of water gastric emptying patterns on model drug release in an in vitro glass-bead flow-through system [0.03%]
预测胃排空模式对体外流动系统模型药物释放的影响
Tjaša Felicijan,Marija Bogataj
Tjaša Felicijan
Oral solid dosage forms are most frequently administered with a glass of water which empties from the stomach relatively fast, but with a certain variability in its emptying kinetics. The purpose of this study was thus to simulate different...