Analysis of doxorubicin and fullerenol in rat serum by micellar electrokinetic capillary chromatography [0.03%]
毛细管电色谱-聚氧乙烯单硬脂酸酯胶束液相色谱法测定大鼠血清中多柔比星和富勒烯酚
Rade Injac,Miranda Sertić,Nina Kočevar Glavač
Rade Injac
A new micellar electrokinetic capillary chromatographic (MEKC) method has been developed and optimized for simultaneous quantitation of doxorubicin (Dox) and fullerenol (Frl) in rat serum. The separation was carried out in a capillary (48.5...
Exploring novel pharmacological trends: Natural compounds in dry eye disease management [0.03%]
探索新型药理学趋势：干燥眼病管理中的天然化合物
Tibor Rák,Adrienne Csutak
Tibor Rák
Dry eye disease (DED) is an ocular condition characterized by altered tear film homeostasis, resulting in symptoms like tear film instability, hyperosmolarity, inflammation, and neurosensory abnormalities. It affects visual acuity and quali...
Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability [0.03%]
生物制药配方中的替代缓冲体系及其对蛋白质稳定性的影响
Blaž Lebar,Mitja Zidar,Janez Mravljak et al.
Blaž Lebar et al.
The formulation of biopharmaceutical drugs is designed to eliminate chemical instabilities, increase conformational and colloidal stability of proteins, and optimize interfacial stability. Among the various excipients involved, buffer compo...
Trifarotene alleviates skin photoaging injury by inhibition of JNK/c-Jun/MMPs [0.03%]
三氟拉星通过抑制JNK/c-Jun/MMPs缓解皮肤光老化损伤
Xuan Fei,Lele Zixin Yang,Jingjing Zhang et al.
Xuan Fei et al.
Long-term exposure to ultraviolet (UV) radiation induces skin photoaging, which manifests as oxidative stress, inflammation, and collagen degradation. Multiple approaches (topical or systemic retinoids, antioxidants, alpha-hydroxy acids, la...
Synthesis and biochemical evaluation of new 3-amido-4-substituted monocyclic ß-lactams as inhibitors of penicillin-binding protein(s) [0.03%]
新的3-氨甲酰基-4-取代单环β-内酰胺类化合物的合成及其作为青霉素结合蛋白（s）抑制剂的生化评价
Katarina Grabrijan,Nika Strašek Benedik,Alen Krajnc et al.
Katarina Grabrijan et al.
In the final phases of bacterial cell wall synthesis, penicillin-binding proteins (PBPs) catalyze the cross-linking of peptidoglycan. For many decades, effective and non-toxic β-lactam antibiotics have been successfully used as mimetics of...
PPIA, HRPT1, and PGK1 genes as the appropriate combination for RT-qPCR normalization in alveolar and femoral bone remodeling in olanzapine-treated rats [0.03%]
奥氮平处理的大鼠肺泡和股骨骨重建的RT-qPCR归一化合适的内参基因组合PPIA、HRPT1和PGK1
Saranda Disha-Ibrahimi,Gorazd Drevenšek,Martina Drevenšek et al.
Saranda Disha-Ibrahimi et al.
Reliable gene expression analysis in bone remodeling studies requires an appropriate selection of internal controls, i.e. stable reference genes for the normalization of quantitative real-time PCR (RT-qPCR), the most common method used for ...
Personalization of thiopurine therapy: Current recommendations and future perspectives [0.03%]
硫嘌呤个性化治疗：当前推荐和未来展望
Dunja Urbančič,Flaka Pasha,Alenka Šmid et al.
Dunja Urbančič et al.
Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bo...
Efficacy of sorafenib plus transcatheter arterial chemoembolization in treating hepatocellular carcinoma with portal vein tumor thrombosis: A meta-analysis [0.03%]
索拉非尼联合介入治疗与单纯介入治疗门静脉癌栓肝细胞肝癌的疗效meta分析
Li Xu,Shanshan Chen,Haijun Cao et al.
Li Xu et al.
This meta-analysis aimed to evaluate the efficacy of sorafenib plus transcatheter arterial chemoembolization (TACE) in treating hepato-cellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). Twelve randomized controlled trials pu...
The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver [0.03%]
酪氨酸激酶抑制剂仑伐替尼由大鼠细胞色素P450氧化并影响其在大鼠肝脏中的表达
Radek Indra,Sandra Jelínková,Katarína Kollárová et al.
Radek Indra et al.
Lenvatinib is an orally effective tyrosine kinase inhibitor used to treat several types of tumors, including progressive, radioiodine-refractory differentiated thyroid cancer and advanced renal cell carcinoma. Although this drug is increasi...
Enhanced biomedical potential of polyurethane/hydroxyapatite composites through chemical modification: A comprehensive study on structure, morphology, and cytocompatibility for tissue regeneration [0.03%]
通过化学改性增强聚氨酯/羟基磷灰石复合材料的生物医学潜力：关于组织再生结构、形貌和细胞相容性的全面研究
Misbah Sultan,Shaista Parveen,Mohammad N Uddin et al.
Misbah Sultan et al.
Polyurethane/hydroxyapatite (PU/HA) composites are well-known for various biomedical applications. This study reports a chemical approach to improve the interaction between HA and PU matrix. HA was surface-modified with 1,6-hexamethylene di...