Personalization of thiopurine therapy: Current recommendations and future perspectives [0.03%]
硫嘌呤个性化治疗：当前推荐和未来展望
Dunja Urbančič,Flaka Pasha,Alenka Šmid et al.
Dunja Urbančič et al.
Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bo...
Efficacy of sorafenib plus transcatheter arterial chemoembolization in treating hepatocellular carcinoma with portal vein tumor thrombosis: A meta-analysis [0.03%]
索拉非尼联合介入治疗与单纯介入治疗门静脉癌栓肝细胞肝癌的疗效meta分析
Li Xu,Shanshan Chen,Haijun Cao et al.
Li Xu et al.
This meta-analysis aimed to evaluate the efficacy of sorafenib plus transcatheter arterial chemoembolization (TACE) in treating hepato-cellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). Twelve randomized controlled trials pu...
The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver [0.03%]
酪氨酸激酶抑制剂仑伐替尼由大鼠细胞色素P450氧化并影响其在大鼠肝脏中的表达
Radek Indra,Sandra Jelínková,Katarína Kollárová et al.
Radek Indra et al.
Lenvatinib is an orally effective tyrosine kinase inhibitor used to treat several types of tumors, including progressive, radioiodine-refractory differentiated thyroid cancer and advanced renal cell carcinoma. Although this drug is increasi...
Enhanced biomedical potential of polyurethane/hydroxyapatite composites through chemical modification: A comprehensive study on structure, morphology, and cytocompatibility for tissue regeneration [0.03%]
通过化学改性增强聚氨酯/羟基磷灰石复合材料的生物医学潜力：关于组织再生结构、形貌和细胞相容性的全面研究
Misbah Sultan,Shaista Parveen,Mohammad N Uddin et al.
Misbah Sultan et al.
Polyurethane/hydroxyapatite (PU/HA) composites are well-known for various biomedical applications. This study reports a chemical approach to improve the interaction between HA and PU matrix. HA was surface-modified with 1,6-hexamethylene di...
Tannic acid elicits differential gene regulation in prostate cancer apoptosis [0.03%]
棓酸誘導前列腺癌細胞凋亡之相關基因調控研究
Sinan Kandir,Sevtap Karakurt,Çiğdem Gökçek-Saraç et al.
Sinan Kandir et al.
Prostate cancer is a significant global health concern that requires innovative therapeutic investigations. Here, the potential anticancer properties of tannic acid were evaluated by examining its effects on apoptosis in prostate cancer cel...
Lipid-based systems with precipitation inhibitors as formulation approach to improve the drug bioavailability and/or lower its dose: a review [0.03%]
脂质系统与沉淀抑制剂的药物递送策略改善生物利用度及降低给药剂量的研究进展综述
Mila Kovačević,Mirjana Gašperlin,Alenka Zvonar Pobirk
Mila Kovačević
Lipid-based systems, such as self-microemulsifying systems (SMEDDS) are attracting strong attention as a formulation approach to improve the bioavailability of poorly water-soluble drugs. By applying the "spring and parachute" strategy in d...
Lyophilised protein formulations as a patient-centric dosage form: A contribution toward sustainability paradigm [0.03%]
以患者为中心的给药形式：迈向可持续发展模式的冷冻干燥蛋白制剂
Maja Bjelošević Žiberna,Pegi Ahlin Grabnar,Mirjana Gašperlin et al.
Maja Bjelošević Žiberna et al.
At present, society has embraced the fact apropos population aging and climate changes, that demand, amongst others, innovative pharmaceutical technologies, emphasising the development of patient-specific delivery systems and thus the provi...
The potential of three-dimensional printing for pediatric oral solid dosage forms [0.03%]
三维打印在儿科固体口服制剂中的应用前景
Klemen Kreft,Marina Fanous,Volker Möckel
Klemen Kreft
Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compoundi...
Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function [0.03%]
大麻籽或亚麻籽油基液晶的临床应用：其对皮肤屏障功能影响的评估
Mercedes Vitek,Mirjam Gosenca Matjaž
Mercedes Vitek
The principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for the development of skin diseases such as atopic dermatitis (AD), which is the...
Randomized Controlled Trial
Acta pharmaceutica (Zagreb, Croatia). 2024 May 30;74(2):301-313. DOI:10.2478/acph-2024-0014 2024
Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy [0.03%]
斯洛文尼亚十年来老年人镇静和抗胆碱能药物负担的变化趋势及其潜在的用药优化空间
Janja Jazbar,Igor Locatelli,Mitja Kos
Janja Jazbar
This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization ...