Light-induced rearrangement from macrocyclic to bicyclic lactam: A case study of N-chlorinated laurolactam [0.03%]
光照引起的大环到双环内酰胺的重排—十二碳醛乳胶素N氯化物的个例研究
Gabrijel Zubčić,Kristina Pavić,Jiangyang You et al.
Gabrijel Zubčić et al.
Converting macrocycle lactams into bicyclic lactams is proposed as an additional way to further increase the metabolic stability of peptide-based drugs. Unfortunately, the synthesis of bicyclic lactams has to start almost from scratch. This...
Fall risk-increasing drugs and associated health outcomes among community-dwelling older patients: A cross-sectional study in Croatian cohort of the EuroAgeism H2020 project [0.03%]
社区居住老年人增加跌倒风险的药物及其相关的健康结局——EuroAgeism H2020项目克罗地亚队列的横断面研究
Elizabeta Paar,Eleonora De Lai,Margita Držaić et al.
Elizabeta Paar et al.
Our study aimed to assess the prevalence of fall risk-increasing drugs (FRIDs) in a sample of community-residing older patients in Croatia and its association with negative health outcomes. An observational, cross-sectional study was conduc...
Total phenolic content, flavonoid content and antioxidant potential of Petasites hybridus and related species from Croatia and considerations regarding their pharmaceutical significance [0.03%]
Petasites hybridus和与其相关的克罗地亚植物的总苯酚含量、黄酮类含量及其抗氧化潜力的评估与相关药用价值的探讨
Maja Friščić,Katarina Vilić,Sandra Jurić et al.
Maja Friščić et al.
Extracts obtained from common butterbur (Petasites hybridus), standardized to petasins, are existing pharmaceutical options for the treatment and/or prevention of allergic rhinitis (leaves) and migraine (rhizomes). In this study, the total ...
Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids [0.03%]
哈米森、哈明和铁ocene衍生物复合物的抗glioblastoma潜力研究
Goran Poje,Davor Šakić,Marina Marinović et al.
Goran Poje et al.
The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise ...
Analysis of doxorubicin and fullerenol in rat serum by micellar electrokinetic capillary chromatography [0.03%]
毛细管电色谱-聚氧乙烯单硬脂酸酯胶束液相色谱法测定大鼠血清中多柔比星和富勒烯酚
Rade Injac,Miranda Sertić,Nina Kočevar Glavač
Rade Injac
A new micellar electrokinetic capillary chromatographic (MEKC) method has been developed and optimized for simultaneous quantitation of doxorubicin (Dox) and fullerenol (Frl) in rat serum. The separation was carried out in a capillary (48.5...
Exploring novel pharmacological trends: Natural compounds in dry eye disease management [0.03%]
探索新型药理学趋势：干燥眼病管理中的天然化合物
Tibor Rák,Adrienne Csutak
Tibor Rák
Dry eye disease (DED) is an ocular condition characterized by altered tear film homeostasis, resulting in symptoms like tear film instability, hyperosmolarity, inflammation, and neurosensory abnormalities. It affects visual acuity and quali...
Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability [0.03%]
生物制药配方中的替代缓冲体系及其对蛋白质稳定性的影响
Blaž Lebar,Mitja Zidar,Janez Mravljak et al.
Blaž Lebar et al.
The formulation of biopharmaceutical drugs is designed to eliminate chemical instabilities, increase conformational and colloidal stability of proteins, and optimize interfacial stability. Among the various excipients involved, buffer compo...
Trifarotene alleviates skin photoaging injury by inhibition of JNK/c-Jun/MMPs [0.03%]
三氟拉星通过抑制JNK/c-Jun/MMPs缓解皮肤光老化损伤
Xuan Fei,Lele Zixin Yang,Jingjing Zhang et al.
Xuan Fei et al.
Long-term exposure to ultraviolet (UV) radiation induces skin photoaging, which manifests as oxidative stress, inflammation, and collagen degradation. Multiple approaches (topical or systemic retinoids, antioxidants, alpha-hydroxy acids, la...
Synthesis and biochemical evaluation of new 3-amido-4-substituted monocyclic ß-lactams as inhibitors of penicillin-binding protein(s) [0.03%]
新的3-氨甲酰基-4-取代单环β-内酰胺类化合物的合成及其作为青霉素结合蛋白（s）抑制剂的生化评价
Katarina Grabrijan,Nika Strašek Benedik,Alen Krajnc et al.
Katarina Grabrijan et al.
In the final phases of bacterial cell wall synthesis, penicillin-binding proteins (PBPs) catalyze the cross-linking of peptidoglycan. For many decades, effective and non-toxic β-lactam antibiotics have been successfully used as mimetics of...
PPIA, HRPT1, and PGK1 genes as the appropriate combination for RT-qPCR normalization in alveolar and femoral bone remodeling in olanzapine-treated rats [0.03%]
奥氮平处理的大鼠肺泡和股骨骨重建的RT-qPCR归一化合适的内参基因组合PPIA、HRPT1和PGK1
Saranda Disha-Ibrahimi,Gorazd Drevenšek,Martina Drevenšek et al.
Saranda Disha-Ibrahimi et al.
Reliable gene expression analysis in bone remodeling studies requires an appropriate selection of internal controls, i.e. stable reference genes for the normalization of quantitative real-time PCR (RT-qPCR), the most common method used for ...