Design, synthesis, and evaluation of a novel fluorescent probe for competitive fluorescence polarization assay to screen galectin-8 inhibitors [0.03%]
设计、合成及评价一种用于筛选半乳糖凝集素-8抑制剂的竞争型荧光偏振分析法探针
Edvin Purić,Marina Marinović,Zala Kojek et al.
Edvin Purić et al.
In the present work, we describe the design, synthesis, and evaluation of a galectin-8- binding fluorescent probe designed for a competitive fluorescence polarization (FP) assay for screening new galectin-8N inhibitors. The probe was charac...
Application of network pharmacology, bioinformatics, computational molecular docking, and experimental validation to study the anticancer effects of oleanolic acid in oral squamous carcinoma cells [0.03%]
网络药理学、生物信息学、计算分子对接和实验验证在研究乌索酸对口腔鳞状细胞癌的抗肿瘤作用中的应用
Ting Yin,Hao Wang,Yaqin Zou
Ting Yin
Oleanolic acid (OA) has demonstrated anticancer effects across various cancers, with some derivatives advancing to clinical trials. Howe ver, its precise mechanisms of action remain unclear, especially in oral squamous cell carcinoma (OSCC)...
Therapeutic effect of umbilical cord mesenchymal stem cells on renal ischemia-reperfusion injury [0.03%]
脐带间充质干细胞对肾缺血再灌注损伤的治疗作用
Liang Xiao,Chengyu Huang,Shanghua Xiao et al.
Liang Xiao et al.
Acute kidney injury (AKI) is a growing global health issue with no effective treatments. This study evaluates the therapeutic effects of umbilical cord mesenchymal stem cells (UC-MSCs) on AKI caused by ischemia-reperfusion injury (IRI) in m...
Untargeted metabolic analysis using LC-Q-TOF-MS and toxicity assessment of Eryngium foetidum in zebrafish embryos [0.03%]
基于LC-Q-TOF-MS的未靶向代谢组学分析及其阴行草对斑马鱼胚胎毒性的评估
Romario Vázquez-Cancino,Sergio Rodríguez-Morales,Nelly Del Carmen Jiménez-Pérez et al.
Romario Vázquez-Cancino et al.
Toxicological studies of edible plant species are important to determine the safety of their consumption. Eryngium foetidum is an edible plant used in some countries for seasoning food and as a natural remedy in folk medicine. Despite this ...
FOXD2-AS1 is modulated by METTL3 with the assistance of YTHDF1 to affect proliferation and apoptosis in esophageal cancer [0.03%]
METTL3在YTHDF1的帮助下通过调节FOXD2-AS1影响食管癌的增殖和凋亡
Zijin Wang,Xing Chen Liu,Zhen Gya Gao et al.
Zijin Wang et al.
This study aims to investigate the regulatory mechanisms of METTL3, YTHDF1, and the long non-coding RNA FOXD2-AS1 in the proliferation and apoptosis of esophageal cancer, with the goal of providing a basis for molecular diagnosis and target...
Acute toxicity and hepatoprotective effect of Arum maculatum on rat liver cirrhosis induced with thioacetamide [0.03%]
Arum maculatum的急性毒性及其对噻唑烷酮诱导的大鼠肝硬化肝脏保护作用
Riyadh Zainadin Mawlood,Kamaran Abdoulrahman
Riyadh Zainadin Mawlood
Arum maculatum is a medicinal plant that has been employed in traditional medicine for treating liver diseases. The objective of the current study was to evaluate the hepatoprotective impacts of ethanolic extract of the A. maculatum leaves ...
Comparative efficacy and safety of vedolizumab and antitumor necrosis factor alfa in patients with inflammatory bowel diseases: A meta-analysis [0.03%]
vedolizumab与抗肿瘤坏死因子alfa治疗炎症性肠病的疗效和安全性的对比：一项荟萃分析研究
Yafang Li,Jin Ding,Chong Lu et al.
Yafang Li et al.
This meta-analysis directly compares the efficacy and safety of vedolizumab and tumor necrosis factor-α (TNF-α) inhibitors for patients with inflammatory bowel disease (IBD), contrary to the previous one which provided an indirect compari...
Marijan Marijan,Lejsa Jakupović,Lovorka Vujić et al.
Marijan Marijan et al.
Biowaste produced in urban parks is composed of large masses of organic matter that is only occasionally used economically. In this work, extracts of six plants widely distributed in urban parks in Central Europe (Achillea millefolium, Cich...
Prevalence and factors associated with potential clinically significant drug-drug interactions in patients with cardiovascular diseases at hospital admission [0.03%]
心血管疾病住院患者潜在具有临床意义的药物相互作用及其影响因素分析
Iva Marović,Mario Udovičić,Diana Rudan et al.
Iva Marović et al.
Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity globally. It is estimated that 17.9 million people died from CVDs in 2019, which represents 32 % of all deaths worldwide. Cardiovascular drugs are the most comm...
Optimization of the suspension procedure by Box-Behnken design for the determination of manganese, iron, and zinc in zeolite clinoptilolite with the TXRF system and insight into its antioxidant properties [0.03%]
基于Box-Behnken设计的悬液过程优化方案及其与抗氧化特性的关系——用TXRF系统测定clinoptilolit沸石中的锰、铁和锌含量
Jasna Jablan,Maja Bival Štefan,Dario Paler et al.
Jasna Jablan et al.
Zeolites are a large family of minerals and the most studied is the naturally occurring clinoptilolite. They possess anti-inflammatory, antioxidant, and detoxifying properties which makes them valuable for medicinal use. Element analysis of...