SARS-CoV-2 structural proteins affect the expression of IL-8 and TNF-α cytokines and APOBEC genes in human lung A549 and liver Huh-7 cells [0.03%]
SARS-CoV-2 结构蛋白影响人肺A549和肝Huh-7细胞中IL-8和TNF-α细胞因子以及APOBEC基因的表达
Martina Bergant Marušič,Margarida Costa,Špela Turk et al.
Martina Bergant Marušič et al.
The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of cytidine deami nases responsible for DNA and RNA sequence editing, playing pivotal roles in a wide range of biological processes, including...
Impact of peroxide content in excipients and antioxidants on famotidine oxidative stability [0.03%]
辅料及抗氧剂中过氧化物含量对法莫替丁氧化稳定性的影响
Alen Gabrič,Žiga Hodnik,Janez Ilaš et al.
Alen Gabrič et al.
Famotidine, a widely used H2-receptor antagonist, exhibits sensitivity to oxidative degradation, particularly in the presence of excipients containing peroxide impurities. This study explores the oxidative stability of famotidine under vari...
Biochemical characteristics of the 6-nitro regioisomer of nitroxoline and its 1,2,3,4-tetrahydroquinoline analogues [0.03%]
6-硝基硝唑酮的区域异构体及其四氢喹啉类似物的生化特性
Ana Mitrović,Damijan Knez,Martina Hrast Rambaher et al.
Ana Mitrović et al.
A significant amount of data about the different pharmacological activities of the established antimicrobial compound nitroxoline (8-hydroxy-5-nitroquinoline) is available in the scientific literature. On the other hand, its regioisomer 8-h...
Damijan Knez,Matic Proj,Krištof Bozovičar et al.
Damijan Knez et al.
The main protease 3CLpro of the SARS-CoV-2 virus is a well--established therapeutic target for the treatment of COVID-19. In this study, we screened an in-house compound library and identified a series of α-heteroarylthiomethyl ketones as ...
Exploration of the chemical space of benzamide-based voltage-gated potassium channel Kv1.3 inhibitors [0.03%]
基于苯胺的电压门控钾通道Kv1.3抑制剂化学空间的研究
Marzia Fois,Špela Pelcar,Joshua A Nasburg et al.
Marzia Fois et al.
The voltage-gated potassium channel Kv1.3 is a key regulator of T-cell activation and a validated therapeutic target for autoimmune and inflammatory diseases. In this study, a ligand-based design strategy was employed to expand a library of...
Development and evaluation of novel InhA inhibitors inspired by thiadiazole and tetrahydropyran series of inhibitors [0.03%]
基于噻二唑和四氢吡喃类抑制剂的新型InhA抑制剂的设计、合成及评价研究
Martina Hrast Rambaher,Nina Gradišek,Rok Frlan et al.
Martina Hrast Rambaher et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a leading global health challenge, exacerbated by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. One promising therapeutic target is ...
Combined shake-flask, chromatographic and in silico approaches for evaluating the physicochemical and ADME properties of aloin A and aloe-emodin [0.03%]
结合摇瓶、色谱及计算机模拟评估番泻苷A和芦荟大黄素的理化性质及ADME属性
Daniela Amidžić Klarić,Jelena Kovačić,Petra Bajt et al.
Daniela Amidžić Klarić et al.
Aloe vera has a long history of medicinal use due to its diverse biological activities, including antioxidant, anti-inflammatory and antimicrobial. This study investigates the physicochemical and ADME (absorption, distribution, metabolism, ...
Phytochemical composition, antioxidant, antiglycation, and antihyperlipidemic activity of flowering parts from five plant species before and after in vitro digestion [0.03%]
五种植物花朵部位及体外消化前后的化学成分、抗氧化、抗糖基化和降血脂活性
Valerija Vujčić Bok,Domagoj Bosiljevac,Ivana Šola et al.
Valerija Vujčić Bok et al.
This study evaluates the antihyperlipidemic (pancreatic lipase inhibition assay), antiglycation (inhibition of bovine serum albumin glycation, BSA glycation), and antioxidant activity (ABTS, DPPH and FRAP assays) of ethanolic extracts from ...
Development of two different eco-friendly label-free platforms for analysis of selumetinib [0.03%]
两种不同的无标记环保型分析平台用于色瑞替尼分析的研究与发展
Sarah Alrubia,Wafa A Alshehri,Nourah Z Alzoman et al.
Sarah Alrubia et al.
Selumetinib (SEL) is a recently approved medication for paediatric patients who have neurofibromatosis type 1. It is the first approved therapy for this rare, debilitating, and disfiguring disease. Development of proper analytical platforms...
Optimization of 6-(trifluoromethyl)pyrimidine derivatives as TLR8 antagonists [0.03%]
作为TLR8拮抗剂的6-（三氟甲基）嘧啶衍生物的优化
Nika Strašek Benedik,Valerij Talagayev,Troy Matziol et al.
Nika Strašek Benedik et al.
Toll-like receptors (TLRs) are essential for the innate immune system as they recognize pathogen-associated molecular patterns and trigger immune responses. Overactivation of TLR8 by endogenous nucleic acids is associated with the developme...