Combined shake-flask, chromatographic and in silico approaches for evaluating the physicochemical and ADME properties of aloin A and aloe-emodin [0.03%]
结合摇瓶、色谱及计算机模拟评估番泻苷A和芦荟大黄素的理化性质及ADME属性
Daniela Amidžić Klarić,Jelena Kovačić,Petra Bajt et al.
Daniela Amidžić Klarić et al.
Aloe vera has a long history of medicinal use due to its diverse biological activities, including antioxidant, anti-inflammatory and antimicrobial. This study investigates the physicochemical and ADME (absorption, distribution, metabolism, ...
Phytochemical composition, antioxidant, antiglycation, and antihyperlipidemic activity of flowering parts from five plant species before and after in vitro digestion [0.03%]
五种植物花朵部位及体外消化前后的化学成分、抗氧化、抗糖基化和降血脂活性
Valerija Vujčić Bok,Domagoj Bosiljevac,Ivana Šola et al.
Valerija Vujčić Bok et al.
This study evaluates the antihyperlipidemic (pancreatic lipase inhibition assay), antiglycation (inhibition of bovine serum albumin glycation, BSA glycation), and antioxidant activity (ABTS, DPPH and FRAP assays) of ethanolic extracts from ...
Development of two different eco-friendly label-free platforms for analysis of selumetinib [0.03%]
两种不同的无标记环保型分析平台用于色瑞替尼分析的研究与发展
Sarah Alrubia,Wafa A Alshehri,Nourah Z Alzoman et al.
Sarah Alrubia et al.
Selumetinib (SEL) is a recently approved medication for paediatric patients who have neurofibromatosis type 1. It is the first approved therapy for this rare, debilitating, and disfiguring disease. Development of proper analytical platforms...
Optimization of 6-(trifluoromethyl)pyrimidine derivatives as TLR8 antagonists [0.03%]
作为TLR8拮抗剂的6-（三氟甲基）嘧啶衍生物的优化
Nika Strašek Benedik,Valerij Talagayev,Troy Matziol et al.
Nika Strašek Benedik et al.
Toll-like receptors (TLRs) are essential for the innate immune system as they recognize pathogen-associated molecular patterns and trigger immune responses. Overactivation of TLR8 by endogenous nucleic acids is associated with the developme...
Design, synthesis, and evaluation of a novel fluorescent probe for competitive fluorescence polarization assay to screen galectin-8 inhibitors [0.03%]
设计、合成及评价一种用于筛选半乳糖凝集素-8抑制剂的竞争型荧光偏振分析法探针
Edvin Purić,Marina Marinović,Zala Kojek et al.
Edvin Purić et al.
In the present work, we describe the design, synthesis, and evaluation of a galectin-8- binding fluorescent probe designed for a competitive fluorescence polarization (FP) assay for screening new galectin-8N inhibitors. The probe was charac...
Application of network pharmacology, bioinformatics, computational molecular docking, and experimental validation to study the anticancer effects of oleanolic acid in oral squamous carcinoma cells [0.03%]
网络药理学、生物信息学、计算分子对接和实验验证在研究乌索酸对口腔鳞状细胞癌的抗肿瘤作用中的应用
Ting Yin,Hao Wang,Yaqin Zou
Ting Yin
Oleanolic acid (OA) has demonstrated anticancer effects across various cancers, with some derivatives advancing to clinical trials. Howe ver, its precise mechanisms of action remain unclear, especially in oral squamous cell carcinoma (OSCC)...
Therapeutic effect of umbilical cord mesenchymal stem cells on renal ischemia-reperfusion injury [0.03%]
脐带间充质干细胞对肾缺血再灌注损伤的治疗作用
Liang Xiao,Chengyu Huang,Shanghua Xiao et al.
Liang Xiao et al.
Acute kidney injury (AKI) is a growing global health issue with no effective treatments. This study evaluates the therapeutic effects of umbilical cord mesenchymal stem cells (UC-MSCs) on AKI caused by ischemia-reperfusion injury (IRI) in m...
Untargeted metabolic analysis using LC-Q-TOF-MS and toxicity assessment of Eryngium foetidum in zebrafish embryos [0.03%]
基于LC-Q-TOF-MS的未靶向代谢组学分析及其阴行草对斑马鱼胚胎毒性的评估
Romario Vázquez-Cancino,Sergio Rodríguez-Morales,Nelly Del Carmen Jiménez-Pérez et al.
Romario Vázquez-Cancino et al.
Toxicological studies of edible plant species are important to determine the safety of their consumption. Eryngium foetidum is an edible plant used in some countries for seasoning food and as a natural remedy in folk medicine. Despite this ...
FOXD2-AS1 is modulated by METTL3 with the assistance of YTHDF1 to affect proliferation and apoptosis in esophageal cancer [0.03%]
METTL3在YTHDF1的帮助下通过调节FOXD2-AS1影响食管癌的增殖和凋亡
Zijin Wang,Xing Chen Liu,Zhen Gya Gao et al.
Zijin Wang et al.
This study aims to investigate the regulatory mechanisms of METTL3, YTHDF1, and the long non-coding RNA FOXD2-AS1 in the proliferation and apoptosis of esophageal cancer, with the goal of providing a basis for molecular diagnosis and target...
Acute toxicity and hepatoprotective effect of Arum maculatum on rat liver cirrhosis induced with thioacetamide [0.03%]
Arum maculatum的急性毒性及其对噻唑烷酮诱导的大鼠肝硬化肝脏保护作用
Riyadh Zainadin Mawlood,Kamaran Abdoulrahman
Riyadh Zainadin Mawlood
Arum maculatum is a medicinal plant that has been employed in traditional medicine for treating liver diseases. The objective of the current study was to evaluate the hepatoprotective impacts of ethanolic extract of the A. maculatum leaves ...