Niosome-based delivery systems for olanzapine: Formulation, characterisation, and kinetic evaluation [0.03%]
奥氮平的尼奥索膜递药系统：处方筛选、表征及动力学评价
Samiah Alhabardi,Basmah Aldosari,Gadah Al-Hamoud et al.
Samiah Alhabardi et al.
This study investigates the development and characterisation of niosome-based delivery systems for olanzapine, an antipsychotic drug. Niosomes were prepared using various grades of Span surfactants (Span 60, Span 40, and Span 20) in combina...
Scutellarin mitigates LPS-ATP-induced cardiomyocyte pyroptosis through the inhibition of the NLRP3/caspase-1/GSDMD signalling pathway [0.03%]
天麻苷元通过抑制NLRP3/ caspase-1 /GSDMD信号通路干预LPS-ATP诱导的心肌细胞焦亡的作用研究
Xiao-Wei Li,Yun-Fei Chen,Lan Zhou et al.
Xiao-Wei Li et al.
Scutellarin has a good myocardial protective effect. However, the underlying mechanism of scutellarin on cardiomyocyte pyroptosis remains unclear. In this study, we elucidated the mechanism of scutellarin to protect the injured myocardium. ...
Recent advances in the treatment of non-alcoholic fatty liver disease with astragaloside IV [0.03%]
Astragaloside Ⅳ治疗非酒精性脂肪肝病的新进展
Hui Wang,Yunqin Jiang,Shiyun Wang et al.
Hui Wang et al.
Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder that has become a global health challenge. With the lack of effective FDA-approved treatments, alternative therapies are being explored. Astragaloside IV (AS-IV), a...
Synthesis of magnetic N-doped carbon dots as pH-responsive targeted molecule cargo and its antioxidant and antibacterial behaviour [0.03%]
合成磁性N掺杂碳点作为pH响应型载药体系及其抗氧化和抗菌行为研究
Hayat Alzahrani,Mohammed S Alkaltham,Tawfiq Alsulami et al.
Hayat Alzahrani et al.
This study successfully generated magnetic N-doped carbon dots (CDs-MNPs) that exhibit two distinct functions: pH-responsive targeted drug delivery and powerful antioxidant action. The structural integrity, magnetic characteristics, and the...
SARS-CoV-2 structural proteins affect the expression of IL-8 and TNF-α cytokines and APOBEC genes in human lung A549 and liver Huh-7 cells [0.03%]
SARS-CoV-2 结构蛋白影响人肺A549和肝Huh-7细胞中IL-8和TNF-α细胞因子以及APOBEC基因的表达
Martina Bergant Marušič,Margarida Costa,Špela Turk et al.
Martina Bergant Marušič et al.
The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of cytidine deami nases responsible for DNA and RNA sequence editing, playing pivotal roles in a wide range of biological processes, including...
Impact of peroxide content in excipients and antioxidants on famotidine oxidative stability [0.03%]
辅料及抗氧剂中过氧化物含量对法莫替丁氧化稳定性的影响
Alen Gabrič,Žiga Hodnik,Janez Ilaš et al.
Alen Gabrič et al.
Famotidine, a widely used H2-receptor antagonist, exhibits sensitivity to oxidative degradation, particularly in the presence of excipients containing peroxide impurities. This study explores the oxidative stability of famotidine under vari...
Biochemical characteristics of the 6-nitro regioisomer of nitroxoline and its 1,2,3,4-tetrahydroquinoline analogues [0.03%]
6-硝基硝唑酮的区域异构体及其四氢喹啉类似物的生化特性
Ana Mitrović,Damijan Knez,Martina Hrast Rambaher et al.
Ana Mitrović et al.
A significant amount of data about the different pharmacological activities of the established antimicrobial compound nitroxoline (8-hydroxy-5-nitroquinoline) is available in the scientific literature. On the other hand, its regioisomer 8-h...
Damijan Knez,Matic Proj,Krištof Bozovičar et al.
Damijan Knez et al.
The main protease 3CLpro of the SARS-CoV-2 virus is a well--established therapeutic target for the treatment of COVID-19. In this study, we screened an in-house compound library and identified a series of α-heteroarylthiomethyl ketones as ...
Exploration of the chemical space of benzamide-based voltage-gated potassium channel Kv1.3 inhibitors [0.03%]
基于苯胺的电压门控钾通道Kv1.3抑制剂化学空间的研究
Marzia Fois,Špela Pelcar,Joshua A Nasburg et al.
Marzia Fois et al.
The voltage-gated potassium channel Kv1.3 is a key regulator of T-cell activation and a validated therapeutic target for autoimmune and inflammatory diseases. In this study, a ligand-based design strategy was employed to expand a library of...
Development and evaluation of novel InhA inhibitors inspired by thiadiazole and tetrahydropyran series of inhibitors [0.03%]
基于噻二唑和四氢吡喃类抑制剂的新型InhA抑制剂的设计、合成及评价研究
Martina Hrast Rambaher,Nina Gradišek,Rok Frlan et al.
Martina Hrast Rambaher et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a leading global health challenge, exacerbated by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. One promising therapeutic target is ...