Chrysin enhances serotonergic and noradrenergic neurotransmission associated with antidepressant effects: A pharmacological study [0.03%]
染料木素通过影响与抗抑郁作用相关的单胺类神经递质系统而产生抗抑郁药理效应的研究
Gilberto-Uriel Rosas-Sánchez,León Jesús Germán-Ponciano,Juan Francisco Rodríguez-Landa et al.
Gilberto-Uriel Rosas-Sánchez et al.
The aim of this study was to investigate the potential antidepressant-like effect of combined subthreshold and effective doses of chrysin and fluoxetine in adult male Wistar rats and their potential effects on the serotonergic and noradrene...
From in vitro studies to product information useful for patients: Evaluation of physical properties and the stability of nasal spray devices containing hydroxypropyl methylcellulose-based liquid and powder formulations [0.03%]
从体外研究到患者有用的产品信息：评估含有羟丙基甲基纤维素液体和粉末制剂的鼻喷雾装置的物理性质和稳定性
Peerawas Kopongpanich,Veerakiet Boonkanokwong,Varin Titapiwatanakun et al.
Peerawas Kopongpanich et al.
Hydroxypropyl methylcellulose (HPMC)-based formulations are commonly used in nasal sprays due to their gelling and viscosity-enhancing properties. However, data on in vitro studies that mimic patient use remain limited. This study investiga...
Cholinergic regulation on polymeric immunoglobulin receptor expression in Caco-2 cells [0.03%]
胆碱能调节对Caco-2细胞聚合免疫球蛋白受体表达的影响
German Higuera-Martínez,David Levaro-Loquio,Aldo Arturo Reséndiz-Albor et al.
German Higuera-Martínez et al.
The polymeric immunoglobulin receptor (pIgR) mediates trans cytosis of IgA, a pivotal anti-inflammatory player of the mucosal immune system. Transcytosis mediated by pIgR entails protein effectors of vesicle-mediated transport involved in s...
Biljana Blažeković,Ines Job Čičin-Mašansker,Marija Kindl et al.
Biljana Blažeković et al.
The quality of chamomile (Matricaria recutita) is largely determined by its content of essential oils and flavonoids, the main pharmacologically active constituents. In this study, the phyto-chemical profiling of 22 commercially available c...
Anticancer activity of Lavandula stoechas L. flower ethanolic extract through apoptotic pathway modulation in colorectal cancer cells [0.03%]
牻牛儿菊 lavender花乙醇提取物通过凋亡途径调节抑制结直肠癌细胞的抗癌活性
Zeynep Doğru,Mustafa Selim Doğru,Gamze Yeşilay et al.
Zeynep Doğru et al.
This study aimed to investigate the anticancer effects and underlying mechanisms of an ethanolic extract of Lavandula stoechas L. flowers (LsHE) on colorectal cancer. The extract demon strated high phenolic content (230.31 ± 11.28 mg GAE g...
Introductory phytochemical analysis and bioactivity screening of Aaronsohnia factorovskyi aerial parts: Antioxidant, anti-inflammatory and antidiabetic insights [0.03%]
艾隆索尼亚福加尔波斯基亚地上部分的初级植物化学分析及生物活性筛选：抗氧化、抗炎和抗糖尿病研究
Elham Amin,Ahlam Elwekeel,Reema I Aljasir et al.
Elham Amin et al.
The current research brings introductory data to phytochemical composition and biological potential of the methanolic extract derived from the aerial parts of Aaronsohnia factorovskyi. In vitro testing was conducted to evaluate its antioxid...
Niosome-based delivery systems for olanzapine: Formulation, characterisation, and kinetic evaluation [0.03%]
奥氮平的尼奥索膜递药系统：处方筛选、表征及动力学评价
Samiah Alhabardi,Basmah Aldosari,Gadah Al-Hamoud et al.
Samiah Alhabardi et al.
This study investigates the development and characterisation of niosome-based delivery systems for olanzapine, an antipsychotic drug. Niosomes were prepared using various grades of Span surfactants (Span 60, Span 40, and Span 20) in combina...
Scutellarin mitigates LPS-ATP-induced cardiomyocyte pyroptosis through the inhibition of the NLRP3/caspase-1/GSDMD signalling pathway [0.03%]
天麻苷元通过抑制NLRP3/ caspase-1 /GSDMD信号通路干预LPS-ATP诱导的心肌细胞焦亡的作用研究
Xiao-Wei Li,Yun-Fei Chen,Lan Zhou et al.
Xiao-Wei Li et al.
Scutellarin has a good myocardial protective effect. However, the underlying mechanism of scutellarin on cardiomyocyte pyroptosis remains unclear. In this study, we elucidated the mechanism of scutellarin to protect the injured myocardium. ...
Recent advances in the treatment of non-alcoholic fatty liver disease with astragaloside IV [0.03%]
Astragaloside Ⅳ治疗非酒精性脂肪肝病的新进展
Hui Wang,Yunqin Jiang,Shiyun Wang et al.
Hui Wang et al.
Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder that has become a global health challenge. With the lack of effective FDA-approved treatments, alternative therapies are being explored. Astragaloside IV (AS-IV), a...
Synthesis of magnetic N-doped carbon dots as pH-responsive targeted molecule cargo and its antioxidant and antibacterial behaviour [0.03%]
合成磁性N掺杂碳点作为pH响应型载药体系及其抗氧化和抗菌行为研究
Hayat Alzahrani,Mohammed S Alkaltham,Tawfiq Alsulami et al.
Hayat Alzahrani et al.
This study successfully generated magnetic N-doped carbon dots (CDs-MNPs) that exhibit two distinct functions: pH-responsive targeted drug delivery and powerful antioxidant action. The structural integrity, magnetic characteristics, and the...