Comparative biodistribution analysis of umbilical cord mesenchymal stromal cells via different administration routes in rabbit models [0.03%]
兔模型中不同给药途径的脐带间充质干细胞的比较生物分布分析
Liang Xiao,Chunlin Liu,Yuqian Wang et al.
Liang Xiao et al.
Umbilical cord mesenchymal stem cells (UC-MSCs) have shown therapeutic potential in renal diseases due to their homing ability. This study compared the effects of three administration routes (intravenous, local renal injection, and interven...
Sedation management in mechanically ventilated intensive care unit patients: Meta-analysis review [0.03%]
机械通气重症监护病房患者镇静管理的meta分析研究
Fawei Yuan,Dong Liu
Fawei Yuan
Sedation is crucial for managing mechanically ventilated intensive care unit (ICU) patients, but agents differ in their effects. Propofol, benzodiazepines and α₂-agonists are commonly used, yet their comparative impact remains unclear. Th...
Pan-Cdk inhibitor ZK304709 suppresses Cdc20 expression and potentiates the anticancer activity of apcin in HeLa cervical cancer cells [0.03%]
泛CDK抑制剂ZK304709通过下调Cdc20表达增强APC激动剂在HeLa宫颈癌细胞中的抗癌活性
Xiangyang Le,Qingsong Chen,Shuyang Cao et al.
Xiangyang Le et al.
Cell division cycle 20 homologue (Cdc20), a key regulator of the anaphase-promoting complex/cyclosome (APC/C), is frequently overexpressed in human cancers and represents a promising therapeutic target. However, monotherapy targeting Cdc20 ...
Gastrointestinal risk profile of tigecycline, omadacycline and eravacycline: Evidence from the FDA adverse event reporting system [0.03%]
替加环素、奥玛克司汀和厄他培南类抗生素的胃肠风险特征：来自美国食品药品监督管理局不良事件报告系统的证据
Zhu Wang,Guoping Gan,Haiping Yao
Zhu Wang
This study assessed the gastrointestinal (GI) safety profiles of tigecycline, omadacycline, and eravacycline through a retrospective disproportionality analysis of reports submitted to the FDA Adverse Event Reporting System (FAERS) between ...
Chrysin enhances serotonergic and noradrenergic neurotransmission associated with antidepressant effects: A pharmacological study [0.03%]
染料木素通过影响与抗抑郁作用相关的单胺类神经递质系统而产生抗抑郁药理效应的研究
Gilberto-Uriel Rosas-Sánchez,León Jesús Germán-Ponciano,Juan Francisco Rodríguez-Landa et al.
Gilberto-Uriel Rosas-Sánchez et al.
The aim of this study was to investigate the potential antidepressant-like effect of combined subthreshold and effective doses of chrysin and fluoxetine in adult male Wistar rats and their potential effects on the serotonergic and noradrene...
From in vitro studies to product information useful for patients: Evaluation of physical properties and the stability of nasal spray devices containing hydroxypropyl methylcellulose-based liquid and powder formulations [0.03%]
从体外研究到患者有用的产品信息：评估含有羟丙基甲基纤维素液体和粉末制剂的鼻喷雾装置的物理性质和稳定性
Peerawas Kopongpanich,Veerakiet Boonkanokwong,Varin Titapiwatanakun et al.
Peerawas Kopongpanich et al.
Hydroxypropyl methylcellulose (HPMC)-based formulations are commonly used in nasal sprays due to their gelling and viscosity-enhancing properties. However, data on in vitro studies that mimic patient use remain limited. This study investiga...
Cholinergic regulation on polymeric immunoglobulin receptor expression in Caco-2 cells [0.03%]
胆碱能调节对Caco-2细胞聚合免疫球蛋白受体表达的影响
German Higuera-Martínez,David Levaro-Loquio,Aldo Arturo Reséndiz-Albor et al.
German Higuera-Martínez et al.
The polymeric immunoglobulin receptor (pIgR) mediates trans cytosis of IgA, a pivotal anti-inflammatory player of the mucosal immune system. Transcytosis mediated by pIgR entails protein effectors of vesicle-mediated transport involved in s...
Biljana Blažeković,Ines Job Čičin-Mašansker,Marija Kindl et al.
Biljana Blažeković et al.
The quality of chamomile (Matricaria recutita) is largely determined by its content of essential oils and flavonoids, the main pharmacologically active constituents. In this study, the phyto-chemical profiling of 22 commercially available c...
Anticancer activity of Lavandula stoechas L. flower ethanolic extract through apoptotic pathway modulation in colorectal cancer cells [0.03%]
牻牛儿菊 lavender花乙醇提取物通过凋亡途径调节抑制结直肠癌细胞的抗癌活性
Zeynep Doğru,Mustafa Selim Doğru,Gamze Yeşilay et al.
Zeynep Doğru et al.
This study aimed to investigate the anticancer effects and underlying mechanisms of an ethanolic extract of Lavandula stoechas L. flowers (LsHE) on colorectal cancer. The extract demon strated high phenolic content (230.31 ± 11.28 mg GAE g...
Introductory phytochemical analysis and bioactivity screening of Aaronsohnia factorovskyi aerial parts: Antioxidant, anti-inflammatory and antidiabetic insights [0.03%]
艾隆索尼亚福加尔波斯基亚地上部分的初级植物化学分析及生物活性筛选：抗氧化、抗炎和抗糖尿病研究
Elham Amin,Ahlam Elwekeel,Reema I Aljasir et al.
Elham Amin et al.
The current research brings introductory data to phytochemical composition and biological potential of the methanolic extract derived from the aerial parts of Aaronsohnia factorovskyi. In vitro testing was conducted to evaluate its antioxid...