Reply to Christelli et al.: Implementation of new Westgard Rules suggested by the Westgard Advisor software for five immunological parameters. What Six Sigma, quality control, the analytical Sigma-metric, and Westgard Advisor can and cannot do [0.03%]
对Christelli等人的回复：关于Westgard Advisor软件建议的新Westgard规则在五个免疫学参数中的应用。Six Sigma、质量控制、分析Sigma度量及Westgard Advisor的作用与局限性
Sten Westgard,Hassan Bayat
Sten Westgard
The study of Cristelli et al. attempted to find fault with the rules suggested by Westgard Advisor software, claiming that implementing those rules did not improve the method performance. A fundamental misunderstanding of the utility and pu...
National recommendations of the Working group for laboratory diagnostics of autoimmune diseases of the Croatian Society of Medical Biochemistry and Laboratory Medicine: Assessment of antineutrophil cytoplasmic antibodies (ANCA) [0.03%]
克罗地亚医学生化学和实验医学会自身免疫性疾病实验室诊断工作组的国家建议：抗中性粒细胞胞浆抗体（ANCA）检测评估
Ana Kozmar,Andrea Tešija Kuna,Nada Tomić Sremec et al.
Ana Kozmar et al.
The family of antineutrophil cytoplasmic antibodies (ANCA) includes autoantibodies targeting proteins within the primary granules of neutrophils and lysosomes of monocytes. So far, proteinase 3 (PR3) and myeloperoxidase (MPO) are considered...
Interfering heterophile antibodies as the cause of persistently falsely elevated high-sensitivity troponin I on Alinity i: a case report [0.03%]
干扰异磷酯抗体导致艾林蒂仪高敏肌钙I持续假阳性升高1例报告
Ivana Lapić,Dunja Rogić,Dragana Šegulja et al.
Ivana Lapić et al.
Hereby we describe a case of a 59-year-old female patient with persistently elevated high-sensitivity troponin I (hs-TnI) over the course of almost four years measured on Alinity i with the corresponding assay (Abbott Laboratories, Chicago,...
Case Reports
Biochemia medica. 2025 Jun 15;35(2):021001. DOI:10.11613/BM.2025.021001 2025
Juan José Perales-Afán,Diego Aparicio-Pelaz,Juan José Puente-Lanzarote et al.
Juan José Perales-Afán et al.
Introduction: 25-hydroxyvitamin D (25-OH-D) is essential for calcium homeostasis and bone health, with increasing evidence suggesting associations with non-skeletal diseases. However, the lack of consensus on optimal conc...
Routine data analysis for moderate hemolysis interference correction in neuron specific enolase quantification [0.03%]
中度溶血干扰下神经元特异性烯醇化酶定量的常规数据分析校正方法研究
Leyre Ruiz,Tomás Munoz,Alvaro González et al.
Leyre Ruiz et al.
Introduction: Serum neuron specific enolase (NSE) is used as neuroendocrine tumor and central nervous system damage marker. It is present in variable concentrations in erythrocytes and hemolysis interferes in serum NSE qu...
Cumulative IgG reagent carryover detected in carryover evaluation of urinary total protein testing using AU5800 biochemistry analyzer [0.03%]
AU5800生化分析仪尿总蛋白检测携带污染评估中检出累计IgG试剂交叉污染
Jialu Li,Guoxiang Bao
Jialu Li
Introduction: Accurate measurement of urinary total protein (UTP) is crucial for diagnosing renal and systemic diseases. This study aims to comprehensively evaluate potential carryover scenarios in UTP testing using AU580...
Ivana Čepelak,Slavica Dodig,Ivan Pavić
Ivana Čepelak
For decades, bilirubin was thought to be merely a degradation product of the hem, a potentially toxic compound and a molecule with no specific physiological function. Recently, it has been discovered that bilirubin has a strong antioxidant ...
Use of Hoteling's T2 multivariate control chart for effective monitoring of a laboratory test with a 3-level quality control scheme [0.03%]
霍特林T2多元控制图在三级质控方案实验室检测监控中的应用研究
Cristiano Ialongo
Cristiano Ialongo
Introduction: A control chart based on Hotelling's T2 multivariate statistics was used to monitor the quality of an immunoenzymatic assay for plasma levetiracetam. The chart incorporated a multi-level quality control (MLQ...
Telomere length and oxidative stress in small cell lung cancer patients: changes through chemotherapy cycles compared to healthy controls [0.03%]
小细胞肺癌患者端粒长度和氧化应激与健康人的对比变化及化疗周期的影响研究
Azra Guzonjić,Dragana Jovanović,Ivana Simić et al.
Azra Guzonjić et al.
Introduction: Small cell lung cancer (SCLC) is an aggressive malignant disease with poor survival outcomes. The aim of this study was to investigate leukocyte telomere length (LTL) and redox status parameters during chemo...
Evaluation of the impact of reducing fasting hours on laboratory results in a mediterranean population [0.03%]
评估减少空腹时间对地中海人群实验室检测结果影响的研究
Gemma Solé-Enrech,Ruth Cano-Corres,Raquel Escribano-Tembleque et al.
Gemma Solé-Enrech et al.
Introduction: One of the critical points of the preanalytical phase is the patient's adherence to the required fasting duration before undergoing medical analysis. Although many laboratories have already protocols for blo...