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Biochemia medica. 2025 Jun 15;35(2):020706. doi: 10.11613/BM.2025.020706 Q31.82025

National recommendations of the Working group for laboratory diagnostics of autoimmune diseases of the Croatian Society of Medical Biochemistry and Laboratory Medicine: Assessment of antineutrophil cytoplasmic antibodies (ANCA)

克罗地亚医学生化学和实验医学会自身免疫性疾病实验室诊断工作组的国家建议：抗中性粒细胞胞浆抗体（ANCA）检测评估 翻译改进

Ana Kozmar  1  2, Andrea Tešija Kuna  3  4, Nada Tomić Sremec  1, Lovorka Đerek  4  5, Vedrana Drvar  6, Katarina Gugo  7

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作者单位

  • 1 Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia.
  • 2 University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia.
  • 3 Department of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
  • 4 Catholic University of Croatia, Zagreb, Croatia.
  • 5 Clinical Department of Laboratory Diagnostics, Dubrava University Hospital, Zagreb, Croatia.
  • 6 Clinical Department of Laboratory Diagnostics, Clinical Hospital Center Rijeka, Rijeka, Croatia.
  • 7 Medical Laboratory Diagnostic Division, University Hospital of Split, Split, Croatia.

    • DOI: 10.11613/BM.2025.020706 PMID: 40520655

    摘要 中英对照阅读

    The family of antineutrophil cytoplasmic antibodies (ANCA) includes autoantibodies targeting proteins within the primary granules of neutrophils and lysosomes of monocytes. So far, proteinase 3 (PR3) and myeloperoxidase (MPO) are considered clinically relevant ANCA specificities. National recommendations for the assessment of ANCA are the outcome of the survey done by the Working group (WG) for laboratory diagnostics of autoimmune diseases of the Croatian ... ...点击完成人机验证后继续浏览

    抗中性粒细胞胞浆抗体（ANCA）家族包括针对中性粒细胞初级颗粒和单核细胞溶酶体内的蛋白质的自身抗体。到目前为止，蛋白酶3 (PR3) 和髓过氧化物酶 (MPO) 被认为是临床相关的 ANCA 特异性抗体。克罗地亚医学生物化学与实验室医学协会（CSMBLM）的工作组（WG）对自身免疫疾病实验室诊断的调查结果显示了克罗地亚各实验室在ANCA检测和报告方面的差异性。本文件包含了关于ANCA检测指征、预分析、分析及后分析问题的建议，包括合理的算法和质量控制保障措施。这些建议基于国际上关于 ANCA 检测与报告的一致意见以及其他相关文献，旨在帮助统一 ANCA 检测流程。这些推荐的目标是改善并统一克罗地亚各实验室中的ANCA检测。

    关键词：抗中性粒细胞胞浆抗体；自身免疫；标准化；建议。

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    期刊名：Biochemia medica

    缩写：BIOCHEM MEDICA

    ISSN：1330-0962

    e-ISSN：1846-7482

    IF/分区：1.8/Q3

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    National recommendations of the Working group for laboratory diagnostics of autoimmune diseases of the Croatian Society of Medical Biochemistry and Laboratory Medicine: Assessment of antineutrophil cytoplasmic antibodies (ANCA)