Prognostic significance of HDL-C on long-term mortality in patients with COVID-19 pneumonia in the Turkish population: A potential mechanism for population differences [0.03%]
高密度脂蛋白胆固醇对土耳其新冠肺炎患者长期死亡率的预后意义：人口差异的潜在机制
Ömer Faruk Baycan,Furkan Bölen,Başak Atalay et al.
Ömer Faruk Baycan et al.
Coronavirus disease 2019 (COVID-19) is diagnosed by the evidence of the presence of multiple phenotypes, including thrombosis, inflammation, and alveolar and myocardial damage, which can cause severe illness and mortality. High-density lipo...
Altered fecal microbial and metabolic profile reveals potential mechanisms underlying iron deficiency anemia in pregnant women in China [0.03%]
改变的粪便微生物和代谢谱揭示了中国孕妇缺铁性贫血潜在机制
Haixia Chen,Weigang Wu,Shuming Tang et al.
Haixia Chen et al.
The gut microbiome and its metabolism may provide crucial insight into the cause of iron deficiency anemia (IDA) in pregnant women. This study aimed to investigate the effect of the gut microbiome and its related metabolites on pregnant wom...
Reactive oxygen species activated by mitochondria-specific camptothecin prodrug for enhanced chemotherapy [0.03%]
线粒体靶向喜树碱前药激活的活性氧增强化学治疗
Zhaopei Guo,Zian Wang,Ruifeng Liang et al.
Zhaopei Guo et al.
Camptothecin (CPT) has attracted much attention due to its potent antitumor activities. However, the undesirable physicochemical properties, including poor water-solubility, unstable lactone ring and severe adverse effects limit its further...
Relationship between PD-L1 expression and prognostic factors in high-risk cutaneous squamous and basal cell carcinoma [0.03%]
PD-L1表达与高风险皮肤鳞状细胞和基底细胞癌预后因素的关系
Özden Yülek,Şebnem Batur,Kerem Özcan et al.
Özden Yülek et al.
This study aimed to investigate the programmed cell death-ligand 1 (PD-L1) expression in cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) and its relationship with prognostic factors in tumors that are not in the head...
Mechanism of OTUD5 in non-small cell lung cancer cell proliferation, invasion, and migration [0.03%]
OTUD5在非小细胞肺癌增殖、侵袭和迁移中的机制研究
Xuebing Li,Baohua Lu,Lina Zhang et al.
Xuebing Li et al.
Ovarian tumor protease deubiquitinase 5 (OTUD5) has been discussed as a regulator of cancer development. Herein, the current study set out to explore the molecular mechanism of OTUD5 in non-small cell lung cancer (NSCLC) cell proliferation,...
ORM 1 as a biomarker of increased vascular invasion and decreased sorafenib sensitivity in hepatocellular carcinoma [0.03%]
血小板反应蛋白受体分子1可作为肝癌血管侵袭和索拉非尼敏感性的标志物
Jiangning Gu,Shiqi Xu,Xiang Chen et al.
Jiangning Gu et al.
This study aimed to clarify the role of Orosomucoid 1 (ORM1) in the development and therapy resistance in hepatocellular carcinoma (HCC). The mRNA expression level of ORM1 was analyzed via integrative analysis of Gene Express Omnibus (GEO) ...
Complement C1QC as a potential prognostic marker and therapeutic target in colon carcinoma based on single-cell RNA sequencing and immunohistochemical analysis [0.03%]
基于单细胞RNA测序和免疫组化分析的补体C1QC可作为结直肠癌预后标志物和治疗靶点
Huiming Deng,Yan Chen,Yong Liu et al.
Huiming Deng et al.
Immune cell infiltration plays an essential role in the occurrence and development of colon cancer. However, the main tumor-associated immune cell infiltration and its gene regulation in colon cancer still need to be further clarified in or...
PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway [0.03%]
PLCE1是一个不良预后标志物，并可通过CD70-CD27信号通路促进骨肉瘤免疫逃逸
Linhai Huang,Chundi Liao,Hanhua Wu et al.
Linhai Huang et al.
Phospholipase C epsilon 1 (PLCE1) is involved in the pathogenesis of many cancers. However, the biological role of PLCE1 in osteosarcoma (OS) is still poorly understood. The prognostic survival analysis was performed on the PLCE1gene in the...
Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR4/ NF-κB pathway and protecting the intestinal barrier [0.03%]
IRAK1/4抑制通过抑制TLR4/NF-κB途径和保护肠道屏障来缓解结肠炎
Bo Yan,Xiangjie Li,Linxiang Zhou et al.
Bo Yan et al.
Interleukin-1 receptor-associated kinase 1/4 (IRAK1/4) is the main kinase of the Toll-like receptor (TLR)-mediated pathway, considered a new target for treating inflammatory diseases. Studies showed a significant correlation between TLRs an...
IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation [0.03%]
IC50值不适合作为评估前列腺癌类器官对药物敏感性指标
Yipeng Xu,Gabriela Pachnikova,He Wang et al.
Yipeng Xu et al.
Preclinical models of tumors have the potential to become valuable tools for commercial drug research and development, and 3D culture systems are gaining traction in this area, particularly in prostate cancer (PCa) research. However, nearly...