Clearance of amyloid plaque via focused ultrasonication in a mouse model of Alzheimer's disease [0.03%]
聚焦超声技术通过小鼠模型清除阿尔茨海默病的淀粉样蛋白斑块
Songmin Lee,Jeungeun Kum,Kyeonghwan Kim et al.
Songmin Lee et al.
Background: The success of anti-amyloid-β (Aβ) monoclonal antibodies in recent clinical trials validates the promising approach of clearing amyloid-β in Alzheimer's therapy. Building on these successes, focused ultrasound (FUS), a non-in...
Modulating CD8⁺ T cell immunity through exercise: mechanistic insights and implications for precision immunotherapy [0.03%]
运动调节CD8⁺T细胞免疫的机制及精准免疫治疗意义探究
Xinyuan Zhao,Xu Chen,Pei Lin et al.
Xinyuan Zhao et al.
CD8⁺ T lymphocytes are pivotal effectors of adaptive immunity, executing cytotoxic mechanisms essential for pathogen clearance, tumor surveillance and tissue protection. Their activity is shaped by antigenic stimulation, cytokine networks ...
Nanoparticle retention enables non-invasive detection of metastases by magnetic particle imaging in murine breast cancer models [0.03%]
纳米颗粒滞留可使磁性粒子成像技术无需侵入式检测即可检测小鼠乳腺癌模型的转移病灶
Preethi Korangath,Hayden Carlton,Toby Sanders et al.
Preethi Korangath et al.
Early detection of metastatic disease improves cancer survival, yet existing modalities are limited in their detection capabilities. We propose that magnetic particle imaging (MPI), an emerging technology, can be used for early detection of...
Lipid nanoparticle-formulated DNA acts as a potent immune modulator for cancer immunotherapy through interferon signaling pathways [0.03%]
脂质纳米颗粒递送的DNA通过干扰素信号途径可作为癌症免疫治疗的强力免疫调节剂
Chen-Yi Chiang,Ming-Shu Hsieh,Mei-Yu Chen et al.
Chen-Yi Chiang et al.
Rationale: Plasmid DNA (pDNA) delivered by lipid nanoparticles (LNPs) represents a promising strategy for cancer immunotherapy, offering both stability of nucleic acids and efficient intracellular delivery. This study aimed to evaluate the ...
Neural stem cell-loaded biohybrid hydrogel improves cochlear implants by electrode-neural coupling and neural regeneration [0.03%]
负载神经干细胞的生物杂化水凝胶通过电极-神经连接和神经再生改善耳蜗植入物的效果
Menghui Liao,Xin Zhou,Hao Wei et al.
Menghui Liao et al.
Background: Contemporary cochlear implants (CIs) face unresolved dual challenges: biomechanical-electrochemical mismatch at the electrode-tissue interface and progressive spiral ganglion neuron (SGN) degeneration, severely limiting long-ter...
Cell-free secretome of CD56brightCD16bright directly reprogrammed NK cells enhances wound healing via CCL3/4/5-CCR5 signaling [0.03%]
CD56 bright CD16 bright直接重编程的天然杀伤细胞的无细胞分泌组通过CCL3 / 4 / 5-CCR5信号促进伤口愈合
Jae Yun Kim,Han-Seop Kim,Binna Seol et al.
Jae Yun Kim et al.
Rationale: Natural killer (NK) cells are emerging as a promising source of immunomodulatory secretomes with regenerative potential. However, heterogeneity in primary NK cell populations limits the reproducibility of NK-derived cell-free the...
Accelerated cartilage regeneration via chondrocyte metabolic reprogramming using nano-steroid-conjugated mesenchymal stem cells in osteoarthritis [0.03%]
利用纳米类固醇连接的间充质干细胞进行软骨细胞代谢重编程以加速骨关节炎中软骨再生
Jong Yeong Lee,Jun Young Park,In Ah Kwon et al.
Jong Yeong Lee et al.
Background: Osteoarthritis (OA) is a prevalent and debilitating chronic disease for which there are currently no approved disease-modifying osteoarthritis drugs (DMOADs). While mesenchymal stem cells (MSCs) have emerged as promising DMOAD c...
Longitudinal in vivo (R)-[18F]FBFP PET imaging for preclinical evaluation of cerebral sigma-1 receptor after ischemic stroke [0.03%]
缺血性卒中后纹状体σ-1受体纵向动态变化的(R)-[18F]氟苯环壬烯正电子发射断层成像研究
Jingfei Yang,Luoxia Liu,Huimin Zhou et al.
Jingfei Yang et al.
Rationale: Sigma-1 receptor (sigma-1R) is a promising biomarker and therapeutic target for ischemic stroke. However, the real-time changes in the expression of sigma-1R post-stroke have not been elucidated. (R)-1-(4-[18F]Fluorobenzyl)-4-[(t...
rTMS-induced motor cortex activation drives neural network tissueoid mediated spinal motor neural pathway reconstruction [0.03%]
经颅磁刺激诱导的运动皮层激活驱动神经网络组织体介导的脊髓运动神经通路重建
Jing Xu,Yue Yang,Zhen Chen et al.
Jing Xu et al.
Rationale: The integration of biological and physical interventions represents a promising therapeutic strategy for spinal cord injury (SCI), offering a novel approach to restore disrupted motor pathways. This study investigates whether rep...
A novel mouse cell line model reveals the tumor intrinsic and immune characteristics of EGFR-mutant lung cancer [0.03%]
构建小鼠细胞系模型 揭示EGFR突变型肺癌的肿瘤内在和免疫特征
Yueren Yan,Jun Shang,Chunnan Liu et al.
Yueren Yan et al.
Background: Epidermal growth factor receptor (EGFR) mutations occur frequently in lung adenocarcinoma (LUAD). However, the lack of practical preclinical models has limited our understanding of how EGFR mutations reshape the tumor immune mic...