Panoramic description of ROS-based nanotechnology for osteomyelitis therapy: Challenges, opportunities, and prospects [0.03%]
基于ROS的纳米技术治疗骨髓炎的全景描述：挑战、机遇与前景
Wenqiao Wang,Xiaoying Kong,Jinsheng Shi et al.
Wenqiao Wang et al.
Osteomyelitis, an inflammatory disease of bone and bone marrow caused by infectious microorganisms, has long been a major clinical challenge due to the lack of consistently effective treatment strategies. Conventional therapeutic approaches...
From bench to bedside: the promise and roadblocks of extracellular vesicle therapeutics [0.03%]
从实验室到临床：外泌体治疗的前景与障碍
Jing Zhang,Yuanwei Pan,Peng She et al.
Jing Zhang et al.
Extracellular vesicles (EVs) have transformed the landscape of precision therapeutics, owing to their intrinsic biocompatibility, capacity to transport biomolecules, and ability to cross biological barriers. Benefiting from these advantages...
In vivo Expansion of Regulatory T cells via an Engineered IL-2 Mutein to Suppress Autoimmune Glomerulonephritis [0.03%]
通过工程改造型IL-2 mutein在体内扩增调节性T细胞以抑制自身免疫性肾小球肾炎
Huang Kuang,Cai-Xia Lin,Jing Huang et al.
Huang Kuang et al.
Rationale: Regulatory T (Treg) cells suppress autoimmunity and restrain inflammatory responses, showing promising potential in autoimmune glomerulonephritis (GN) therapy with minimizing nonspecific immunosuppression. Alth...
PSMA-targeted fluorescent probe for NIR-II imaging in prostate cancer intraoperative navigation and tumor margin mapping [0.03%]
用于前列腺癌手术导航和肿瘤边缘定位的近红外II区PSMA靶向荧光探针
Zhongji Jiang,Haozhe Tan,Bo Wu et al.
Zhongji Jiang et al.
Accurate delineation of tumor margins during prostate cancer surgery remains challenging due to limited intraoperative visualization and insufficient molecular specificity. Here, we developed a PSMA-targeted near-infrared fluorescent probe,...
Carbon dots penetrating the blood-brain barrier for central nervous system nanomedicine [0.03%]
能够穿越血脑屏障的碳点用于中枢神经系统纳米医药
Wubshet Mekonnen Girma,Girum Getachew Demissie,Shewaye Lakew Mekuria et al.
Wubshet Mekonnen Girma et al.
Central nervous system (CNS) diseases are challenging to treat because of the blood-brain barrier (BBB), formed by tight junctions that limit the transcellular transport of therapeutic drugs. Carbon dots (CDs) have emerged as versatile nano...
Bimetallic Cu/Fe-MOF-based heterojunction sonozymes for triple amplification of sono-immunotherapy through activating tumor-specific cuproptosis and cGAS-STING pathway [0.03%]
用于激活肿瘤特异性铜死亡和cGAS-STING途径的双金属Cu / Fe-MOF基异质结声酶，以增强声免疫疗法的三重放大作用
Xueyuan Liu,Nan Wang,Jinming Cai et al.
Xueyuan Liu et al.
Background: Initiating ROS-induced ICD and activating innate immune pathways are promising strategies for reprogramming immunosuppressive TME and eliciting persistent antitumor immune responses. ...
Yan Huang,Haoyue Hu,Ruoyu Sun et al.
Yan Huang et al.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, and while immune checkpoint inhibitor (ICI) has transformed treatment, resistance remains a critical challenge. Beyond the T-cell-centric view, tumor-in...
Nanobiomaterial-enabled boron delivery systems and innovative strategies for revolutionizing BNCT [0.03%]
纳米生物材料赋能的硼输送体系及创新策略以革新BNCT治疗
Qiyao Yang,Ruxuan Wang,Huang Lingling et al.
Qiyao Yang et al.
Boron neutron capture therapy (BNCT) is a novel and emerging form of radiotherapy that combines the advantages of "heavy ion radiotherapy" and "biological targeting". The therapeutic potential of BNCT is ultimately constrained by precise an...
Multimodal tumor thermal therapy enhances antitumor immunity by expanding tumor-reactive CX3CR1⁺GPR56⁺ T cells in hepatocellular carcinoma [0.03%]
多模态肿瘤热疗通过扩增CX3CR1+GPR56+瘤反应性T细胞来增强肝癌的抗肿瘤免疫作用
Shicheng Wang,Ying Wang,Yan Zhang et al.
Shicheng Wang et al.
Rationale: Tumor local ablation could facilitate the release of tumor antigens, thereby activating systemic antitumor immunity. Nevertheless, clinical observations have indicated that the systemic response induced by conv...
Tumor metabolic plasticity in therapy resistance: from the Warburg effect to mitochondrial hijacking [0.03%]
治疗抵抗下的肿瘤代谢可塑性：从瓦伯格效应到线粒体功能劫持
Yen-Dun Tony Tzeng,Emmanuel Naveen Raj,Shih-Hsuan Cheng et al.
Yen-Dun Tony Tzeng et al.
The clinical efficacy of targeted cancer therapies is persistently undermined by the emergence of acquired resistance. While secondary genetic mutations are well-characterized, increasing evidence implicates non-genetic metabolic reprogramm...