Sha-Sha Fan,Xuan Xu,Yu-Bin Luo et al.
Sha-Sha Fan et al.
Autoimmune diseases are driven by a breach of self-tolerance, leading to chronic inflammation and organ damage. While the Th1 and Th17 paradigms have long dominated our understanding of T-cell-mediated pathology, a distinct subset of CD4+ T...
Machine learning-enhanced confocal Raman imaging enables label-free diagnosis and spatial metabolic profiling of isoniazid-induced hepatotoxicity [0.03%]
基于机器学习的共聚焦拉曼成像技术实现对异烟肼诱导肝毒性的无标记诊断及代谢图谱绘制
Shimei Wang,Xiaoren Wang,Xudong Cui et al.
Shimei Wang et al.
Rationale: Isoniazid-induced liver injury (INH-ILI) poses a significant clinical challenge due to the lack of reliable, non-invasive, and real-time diagnostic tools. Here, we present an integrated platform that combines label-free confocal ...
EZH2-mediated H3K27me3 links microbial inosine loss to depression: a gut-brain epigenetic switch [0.03%]
肠道-大脑表观遗传开关：EZH2介导的H3K27me3将微生物尿苷减少与抑郁联系起来
Sen Zhu,Xuan Li,Ying Yu et al.
Sen Zhu et al.
Background: Depression, the second most prevalent neurological disorder globally, affects over 300 million people and presents an urgent public health challenge. While gut microbiota dysbiosis is increasingly recognized as a key contributor...
Single-cell RNA sequencing reveals endothelial cell heterogeneity and Sox18-mediated EndMT in abdominal aortic aneurysm [0.03%]
单细胞RNA测序揭示腹主动脉瘤中的内皮细胞异质性和Sox18介导的内皮-间充质转化
Xianxian Wu,Xuanyu Liu,Yuanzhi Cheng et al.
Xianxian Wu et al.
Rationale: Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease lacking clinical predictors and effective pharmacologic therapies. The cellular heterogeneity and molecular changes of different cell types during AAA h...
Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC [0.03%]
Hsa_circ_0058495介导的IGF2BP2泛素化和MEKK1的m6A修饰促进胰腺癌进展
Shengnan Lv,Jian Zhang,Xinyu Peng et al.
Shengnan Lv et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with dismal clinical outcomes. We identified hsa_circ_0058495 as significantly upregulated in PDAC tissues and PDAC cell-derived exosomes, where it contri...
Biofilm-disrupting heterojunction microneedles: dual ROS amplification and glucose deprivation for accelerated diabetic wound healing [0.03%]
生物膜破坏型异质结微针：双重ROS放大和葡萄糖剥夺促进加速糖尿病伤口愈合
Wenjie You,Feng Xiao,Zichao Cai et al.
Wenjie You et al.
Rationale: Diabetic wound healing process is critically hindered by bacterial infection, bacterial biofilm formation, and persistent hyperglycemia. Biomolecular microneedles represent a promising alternative to conventional therapies such a...
Endothelial cell-derived SDF-1α elicits stemness traits of glioblastoma via dual-regulation of GLI1 [0.03%]
内皮细胞衍生的SDF-1α通过GLI1的双重调节激发胶质母细胞瘤干细胞特性
Ye Yuan,Xudong Liu,Liwen Kuang et al.
Ye Yuan et al.
Background: Glioma stem cells (GSCs) play a critical role in the poor treatment outcomes observed in glioblastoma (GBM) patients. A primary focus of current glioma research is understanding the maintenance of stemness in GSCs and their inte...
Ultrasound flow imaging for assessing cerebrovascular changes following focused-ultrasound blood-brain barrier opening [0.03%]
聚焦超声打开血脑屏障后的颅内血管变化的 ultrasound 流体成像评估方法
Sua Bae,Stephen A Lee,Seongyeon Kim et al.
Sua Bae et al.
Rationale: Microbubble-mediated focused ultrasound (Mb-FUS) is a promising non-invasive technique for blood-brain barrier opening (BBBO), enhancing drug delivery and immunomodulation for brain disease treatments. In Mb-FUS, microbubble cavi...
Hot-spot empowered gold nanoparticles for theranostics in breast cancer [0.03%]
热点活化的金纳米粒子在乳腺癌诊疗中的应用研究
Meng Tian,Shiqi Hu,Wen Sun et al.
Meng Tian et al.
Breast cancer, being the most prevalent malignant tumor among women, confronts severe challenges in its early detection and precise treatment. Traditional diagnostic approaches have drawbacks in terms of sensitivity and specificity, and are...
Trimmed N-glycans define aggressive gastric cancer and predict clinical outcomes [0.03%]
截短的N-糖链定义了侵袭性的胃癌并预测临床结果
Dylan Ferreira,Beatriz Marinho-Santos,Marta Relvas-Santos et al.
Dylan Ferreira et al.
Rationale: Gastric cancer (GC) is a leading cause of cancer-related mortality, particularly in advanced stages where prognosis and targeted treatment remain challenging. The glycocalyx, a dense network of glycans and glycoproteins, is criti...