Efferocytosis in heart failure: Mechanisms, dysregulation and therapeutic potential [0.03%]
心脏衰竭中的凋亡细胞清除作用：机制、调控失常和治疗潜能
Otega Oviri,Shijie Liu,Hongye Huang et al.
Otega Oviri et al.
Heart failure (HF) remains one of the leading health problems globally. It is often characterized by unresolved inflammation, adverse cardiac remodeling, and tissue damage. Efferocytosis, the process by which phagocytes clear apoptotic cell...
Scalable differentiation of human cardiac organoids from iPSCs generates cardiac tissues for cardiac cell therapy [0.03%]
人多能干细胞衍生类心脏器官的可扩展分化为心脏细胞治疗提供可供选择的心脏组织来源
Sarkawt Hamad,Ebru Aksoy,Maria Kalil et al.
Sarkawt Hamad et al.
Rationale: Cardiac organoids have the potential to overcome the limitations of cell-based therapies for myocardial infarction, particularly by improving cell engraftment. ...
Reversing Bladder Cancer Chemo-resistance through Blocking Cell Senescence by a Combination Therapy [0.03%]
通过联合疗法阻断细胞衰老以逆转膀胱癌化疗耐药性
Yirui He,Zaixiang Fang,Jiapeng Zhang et al.
Yirui He et al.
Rationale: Chemoresistance severely limits therapeutic options for advanced bladder cancer. Histone deacetylases (HDACs) have been implicated in tumour progression and treatment resistance, yet their role in acquired chem...
Epigenetic subtypes of high-grade T1 bladder cancer reveal intra-tumor heterogeneity and distinct interactions with tumor microenvironment [0.03%]
高级T1期膀胱癌的表观遗传亚型揭示了肿瘤异质性及与肿瘤微环境的独特相互作用
Joaquim Bellmunt,Yingtian Xie,Nuria Juanpere et al.
Joaquim Bellmunt et al.
Rationale: High-grade T1 (HGT1) Non-Muscle Invasive Bladder Cancer (NMIBC) is a clinically heterogeneous disease characterized by unpredictable treatment responses and limited tools for recurrence prediction. Despite adva...
Development and in vivo evaluation of 18F-labeled PET tracers covalently targeting KRAS-G12C for noninvasive cancer diagnosis and therapy monitoring [0.03%]
用于非侵入性癌症诊断和治疗监测的靶向KRAS-G12C的正电子发射断层成像示踪剂的开发及体内评价
Michael Willmann,Jens P Bankstahl,Frank M Bengel et al.
Michael Willmann et al.
Rationale: Mutations in the KRAS gene are some of the most frequent drivers in cancer, including non-small cell lung and colorectal cancer. Covalent inhibitors such as adagrasib, targeting the inactive, GDP-bound form of ...
Converging chemistry and clinical orthopedics in the emerging role of MOFs in advanced bone defect repair [0.03%]
收敛化学与临床骨科在金属有机框架材料在高级骨缺损修复中的新兴作用中
Yangmengfan Chen,Xiaoyang Liu,Xuming Chen et al.
Yangmengfan Chen et al.
In recent years, metal-organic frameworks (MOFs) have attracted significant attention in regenerative medicine due to their exceptional structural tunability, high surface-to-volume ratios, and controllable porosity. This review systematica...
Human Multi-Organ-on-a-Chip Platforms for Next-Generation Drug Delivery Strategies [0.03%]
下一代药物输送策略的人类多器官芯片平台
Cosmo S Mitchell,Hong-Il Yoo,Carolina Gracia Diaz et al.
Cosmo S Mitchell et al.
Human multi-organ-on-a-chip (MOoC) platforms have rapidly emerged as next-generation preclinical models for evaluating therapeutic delivery and efficacy. By integrating dynamic perfusion, physiologically relevant microenvironments, and syst...
Primary Cilium Forces Neuroendocrine Shift in Prostate Cancer through YAP1 Repression and Reduced Mitochondrial Activity [0.03%]
纤毛通过YAP1抑制和降低线粒体活性诱导前列腺癌的神经内分泌转化
Yingbo Guo,Siyong Peng,Thibaud Jamet et al.
Yingbo Guo et al.
Primary cilia are increasingly recognized as regulators of cellular signaling and plasticity. Here, we examined their distribution and potential relevance in neuroendocrine (NE) prostate cancer. While typically absent in localized hormone-s...
ecPICK: A deep learning-enabled spatial diagnostic platform for direct ecDNA identification and clinical prognosis across pan-cancer histopathology [0.03%]
基于深度学习的全癌种组织病理学切片中环状染色体dna直接识别与预后诊断平台ecnickd：构建、训练与验证
Xue-Ting Zhen,Zhen Yang,Lu-Ning Qin et al.
Xue-Ting Zhen et al.
Rationale: Extrachromosomal DNA (ecDNA) is an important driver of oncogene amplification and drug resistance; however, its clinical assessment is constrained by the high costs of sequencing and lack of spatial resolution ...
Converting focused ultrasound-based boiling histotripsy into a systemic cancer vaccine using antigen-capturing microparticles [0.03%]
利用抗原捕获微粒将基于聚焦超声的组织消融技术转化为系统性癌症疫苗
Akansha Singh,Sri Vidhya Chandrasekar,Faraz Chamani et al.
Akansha Singh et al.
Background: Tumors with an immunosuppressive tumor microenvironment (TME) limit effective anti-tumor immunity. Focused ultrasound-based boiling histotripsy (HT) is a noninvasive technique that mechanically ablates tumors ...