Splicing factor FUS facilitates the progression of PIT1-lineage PitNETs by upregulating MDM2 [0.03%]
剪接因子FUS通过上调MDM2促进PIT1谱系垂体神经内分泌肿瘤的发生发展
Xu Wang,Jiang Li,Chenggang Jiang et al.
Xu Wang et al.
Background: Splicing factors play pivotal roles in mRNA processing and are implicated in tumor progression. The aberrant expression of splicing factors is closely associated with the invasiveness and secretion profiles of pituitary neuroend...
Nanotechnology-donated ischemic stroke therapeutics: evolving strategies from the basic to the cutting-edge [0.03%]
纳米技术捐赠的缺血性卒中治疗策略：从基础到前沿的发展策略
Yuting Wang,Jiaxu Xu,Wenxuan Yan et al.
Yuting Wang et al.
Ischemic stroke (IS) is accompanied by high disability and mortality. Thrombolysis and neuroprotection are the predominant therapeutic strategies for IS. However, thrombolytic drugs commonly suffer from hemorrhagic risks and unsatisfactory ...
Ligand-directed oral lipidic nanoplatform enables sustained ferroptosis and immune reprogramming via multivalent transporter-mediated metronomic delivery [0.03%]
配体导向的口服脂质纳米平台通过多价转运蛋白介导的_METADATA_递送实现持续铁死亡和免疫重编程
Laxman Subedi,In Ho Im,Arjun Dhwoj Bamjan et al.
Laxman Subedi et al.
Rationale: Ferroptosis-induced tumor cell death and immune activation represent promising strategies for overcoming therapeutic resistance in triple-negative breast cancer (TNBC). However, clinical application remains limited by poor oral a...
Yucen Deng,Ziyu Liu,Xinyuan Zhu et al.
Yucen Deng et al.
Renal diseases remain a major global health burden, with an estimated 850 million individuals affected by chronic kidney disease, acute kidney injury, glomerulonephritis, and diabetic nephropathy. These multifactorial diseases collectively ...
Dual targeting of AMRC12 and Malassezia globosa disrupts MYC liquid condensates-driven nuclear pore complex biogenesis in neuroblastoma [0.03%]
AMRC12和Malassezia globosa的双重靶向破坏神经母细胞瘤中MYC液滴驱动的核孔复合物生物生成
Anpei Hu,Chunhui Yang,Zhijie Wang et al.
Anpei Hu et al.
Rationale: Neuroblastoma (NB) is a predominant extra-cranial malignancy in childhood, while molecular drivers of its progression and effective treatment strategies have yet to be clarified. Methods: RNA sequencing was performed to identify ...
Engineered Dll4-overexpressing osteocyte-derived exosomes enhanced bone regeneration by regulating osteogenesis and angiogenesis [0.03%]
工程化的Dll4过表达骨细胞源外泌体通过调节成骨和血管生成促进骨再生
Yujie Yan,Pengtao Wang,Xi Tang et al.
Yujie Yan et al.
Rationale: Delayed fracture healing often results from impaired osteocyte network reconstruction and inadequate vascularization. Our prior work demonstrated that osteocytes engineered to overexpress Dll4 (Dll4-osteocytes) exert dual pro-ost...
Lead radionuclides for theranostic applications in nuclear medicine: from atom to bedside [0.03%]
核医学诊疗应用的铅放射性同位素：从原子到床边
Yani Berckmans,Janke Kleynhans,Sara Van Mechelen et al.
Yani Berckmans et al.
Lead-212 has emerged as a promising radionuclide for targeted alpha therapy (TAT), positioning itself at the forefront of next-generation cancer treatments. What sets lead-212 apart is its unique decay profile: while it is a beta emitter, i...
Optimizing PSMA-617-based inhibitors through charged linker modifications: Insights into structure-activity relationships [0.03%]
通过带电链接器修饰优化PSMA-617基抑制剂：结构活性关系的见解
Nicolas M Geis,Yvonne Braunwarth,Philipp T Meyer et al.
Nicolas M Geis et al.
Rationale: The introduction of Pluvicto® ([177Lu]Lu-vipivotide tetraxetan; [177Lu]Lu-PSMA-617) marks a milestone in radioligand therapy (RLT) for PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). While dose escalation ...
Targeting CAMK1D-engineered nanoactivator suppresses cancer stem cell maintenance and immune evasion in enzalutamide-resistant prostate cancer [0.03%]
靶向CAMK1D工程纳米活化剂可抑制恩杂鲁胺耐药性前列腺癌干细胞维持和免疫逃逸
Feifei Sun,Yuchuan Yan,Deqing Sun et al.
Feifei Sun et al.
Rationale: Hormonal therapy is fundamental to prostate cancer (PCa) management; however, its long-term efficacy is compromised by enzalutamide resistance (ENZR), which is fuelled by prostate cancer stem-like cells (PCaSCs) and an immunosupp...
Precision radiolabeled B-cell maturation nanobody for targeted PET imaging and radioligand therapy of disseminated multiple myeloma [0.03%]
高精度放射性标记B细胞成熟纳米抗体用于多发性骨髓瘤的PET成像和放射配体治疗
Behnaz Ghaemi,Colleen P Olkowski,Falguni Basuli et al.
Behnaz Ghaemi et al.
Background: Multiple myeloma (MM) is an incurable plasma cell malignancy with limited disease-specific imaging options. Current diagnostic methods often fail to detect early disease states and minimal residual disease, highlighting the need...