Macrophage Nrf1/NFE2L1-Foxo1 axis controls liver fibrosis by modulation of mitochondrial reprogramming [0.03%]
巨噬细胞Nrf1/NFE2L1-Foxo1轴通过调节线粒体重组控制肝纤维化
Yuanbang Lin,Xiyun Bian,Yao Yao et al.
Yuanbang Lin et al.
Rationale: Nuclear factor erythroid 2-like 1 (Nrf1/NFE2L1) is a crucial redox-sensitive factor essential for mitochondrial homeostasis. However, its function in controlling macrophage-associated liver inflammation and fibrosis remains to be...
Channel-specific differential effects of bacterial mechanosensitive channels for ultrasound neuromodulation in precision sonogenetics [0.03%]
声波神经调控中细菌机械敏感性离子通道的通路特异性差异效应在精准声子遗传学中的作用
Xin Li,Chenguang Zheng,Yutao Tian et al.
Xin Li et al.
Rationale: Ultrasound neuromodulation offers promising therapeutic potential, but its effectiveness is limited by imprecise targeting of neural circuits. Engineering mechanosensitive ion channels can enhance ultrasound sensitivity, providin...
Neuronal mitochondrial disaggregase CLPB ameliorates Huntington's disease pathology in mice [0.03%]
神经线粒体解聚酶CLPB可改善小鼠Huntington病的病理变化
Hyeonho Kim,Gaeun Hyun,Seunghye Kim et al.
Hyeonho Kim et al.
Background: Huntington's disease (HD) is a devastating neurodegenerative disorder caused by CAG repeat expansion in the HTT gene, resulting in a polyglutamine-expanded huntingtin (HTT) protein that forms toxic aggregates. Although heat-shoc...
RNA Modifications in T cell Immunity: Mechanisms, Disease Relevance, and Therapeutic Potential [0.03%]
T细胞免疫中的RNA修饰：机制、病理学意义及治疗潜力
Xinyuan Zhao,Meiyan Zou,Weiyao Feng et al.
Xinyuan Zhao et al.
RNA modifications constitute a versatile and dynamic layer of post-transcriptional regulation that enables T lymphocytes to fine-tune gene expression programs in response to developmental, environmental, and pathogenic cues. Chemical marks ...
Hollow RuO2 nanozymes sensitized by carbon dot sonosensitizers for sonodynamic/chemodynamic-activated immunotherapy [0.03%]
空心RuO2纳米酶由碳点声敏化剂敏化，用于声动力/化学动力激活的免疫治疗
Ming Cao,Yanwei Liu,Zhenlin Zhang et al.
Ming Cao et al.
Background: Regulating the morphology structure of sonosensitizers and nanozymes is crucial to improve sonodynamic and enzyme-mimic activities. Methods: We report for the first time the utilization of Cu2O nanospheres as the sacrificial tem...
Erratum: Albumin-seeking dyes with adjustable assemblies in situ enable programmable imaging windows and targeting tumor imaging: Erratum [0.03%]
Correction: 可调组装的寻白蛋白染料实现可编程成像窗口及肿瘤靶向成像：勘误
Yijing Du,Jiajun Xu,Tianyang Han et al.
Yijing Du et al.
[This corrects the article DOI: 10.7150/thno.92991.]. © The author(s).
Published Erratum
Theranostics. 2026 Jan 1;16(5):2559-2560. DOI:10.7150/thno.126837 2026
Microglial TIA1-mediated stress granules promote neuroinflammation and aggravate neuron loss in mice after ischemic stroke by inhibiting IGF2 signaling [0.03%]
小胶质细胞中TIA1介导的应激颗粒通过抑制IGF2信号促进缺血性脑卒中后神经炎症和加重神经元死亡
Yiming Qian,Hong Yu,Jianhong Dong et al.
Yiming Qian et al.
Rationale: Microglia cells as niche homeostasis monitor with rapid responses to acute ischemic stroke (IS). T-cell intracellular antigen 1 (TIA1), a core component of stress granules (SGs), is involved in cellular stress responses such as h...
Functional material probes and advanced technologies in organ-on-a-chip characterization [0.03%]
器官芯片表征的功能材料探针及先进技术
Yanan Wang,Xiao Chang,Shiwen Deng et al.
Yanan Wang et al.
Organ-on-a-Chip (OoC) integrates advanced biomaterials, microfluidics, and cell biology to simulate organ structures and dynamic microenvironments, offering a vital platform for drug development and disease modeling. The miniature scale, st...
Role of central and peripheral serotonin in liver physiology and diseases [0.03%]
中枢和外周血清素在肝脏生理和疾病中的作用
Arnauld Belmer,Carmelo Luci,Philippe Gual
Arnauld Belmer
Steatotic liver diseases (SLD) associated with metabolic dysfunction (Metabolic dysfunction-Associated Steatotic Liver Disease: MASLD), chronic alcohol consumption (alcohol-associated liver disease: ALD), or both (MetALD) represent a major ...
Development of New IL-1R Antagonists with Improved Anti-inflammatory Efficacy [0.03%]
高效新型IL-1R拮抗剂的开发
Mooseok Kang,Ae-Ree Lee,Hyeji Jung et al.
Mooseok Kang et al.
Background: Anakinra, a recombinant human interleukin-1 receptor antagonist (hIL-1Ra), is a widely used anti-inflammatory biologic for conditions like rheumatoid arthritis and gout. However, its limited potency and dose-dependent side effec...