Validation of WHO 2017 Classification and Identification of Prognostic Factors in Patients with Pancreatic Neuroendocrine Neoplasms: A Real-World Experience in Taiwan [0.03%]
WHO 2017分类的验证及胰腺神经内分泌肿瘤患者的预后因素识别：台湾真实世界经验
Wei-Pang Ho,Wen-Chi Chou,Chia-Hsun Hsieh et al.
Wei-Pang Ho et al.
Background: Pancreatic neuroendocrine tumors (PanNETs) are rare neoplasms with an increasing incidence. This study aims to validate the clinical relevance of the WHO 2017 classification system in the Taiwanese population and identify indepe...
Comprehensive Bioinformatics Analysis and Validation of the Mechanism of Glutamic-pyruvic Transaminase 2 in Bladder Cancer [0.03%]
谷氨酸草酰乙酸转氨酶2在膀胱癌中的机制的生物信息学分析及验证
Haonan Dong,Hongqiong Li,Shi Chen et al.
Haonan Dong et al.
Objective: Glutamic pyruvic transaminase 2 (GPT2) promotes the initiation and progression of various cancers. However, its regulatory role in bladder cancer (BCa) remains unclear. In this study, we aimed to validate the role of GPT2 in BCa ...
Lingyuan Min,Shaojie Feng,Xiuxiu Liu et al.
Lingyuan Min et al.
Securin is a key regulator of chromosome segregation during mitosis. Dysregulation of securin triggers chromosomal instability (CIN) and aneuploidy, which are hallmarks of many solid tumors, including breast cancer (BC). Recent studies have...
Capsaicin, the Pungent Component of Red Chili Pepper, induces p21-mediated Cell Cycle Arrest in Renal Cell Carcinoma via Downregulating GLI1: an Experimental Research In Vitro [0.03%]
红辣椒中的辛辣成分辣椒素通过下调GLI1诱导肾细胞癌p21介导的细胞周期停滞：体外实验研究
Long Zheng,Yongchao He,Hao Huang et al.
Long Zheng et al.
Capsaicin is the pungent and bioactive compounds of Capsicum annum. Previous studies have demonstrated the potent anti-tumor effect of capsaicin on various human malignancies by experiments in vitro or in vivo. However, the mechanism underl...
Divulging Patterns: An Analytical Review for Machine Learning Methodologies for Breast Cancer Detection [0.03%]
揭示模式：乳腺癌检测的机器学习方法论解析性综述
Alveena Saleem,Muhammad Umair,Muhammad Tahir Naseem et al.
Alveena Saleem et al.
Breast cancer is a lethal carcinoma impacting a considerable number of women across the globe. While preventive measures are limited, early detection remains the most effective strategy. Accurate classification of breast tumors into benign ...
Isoginkgetin Induces Caspase Cascade Activation and Cell Apoptosis via JNK Signaling in Oral Cancer [0.03%]
异甘草素通过JNK信号通路诱导口腔癌细胞内半胱天冬酶级联激活及细胞凋亡
Wei-En Yang,Chun-Yi Chuang,Chiao-Wen Lin et al.
Wei-En Yang et al.
Isoginkgetin (IGG), a naturally occurring biflavonoid found in the leaves of many medicinal plants, is known to inhibit pre-mRNA splicing and display anti-cancer characteristics. However, knowledge regarding the use of IGG on oral squamous ...
2023 FIGO Staging of Endometrial Cancer with Molecular Classification: Dawn and Challenges [0.03%]
2023FIGO子宫内膜癌分子分型分期共识：迎接黎明与挑战并存的时代
Wei Zhao,Qiqi Xu,Peiyu Feng et al.
Wei Zhao et al.
Objective: To assess the prognostic performance of the 2023 FIGO staging system for endometrial cancer, which incorporates molecular classification (FIGO 2023m), we analyzed survival outcomes and compared them with the 2009 FIGO system (FIG...
Chemopreventive Targeting of Oncogenic Stemness: EGCG-Mediated Suppression of the HIF-1α-PPARγ-Cancer Stem Cells Transcriptional Signature in 3D Glioblastoma Spheroids [0.03%]
表没食子儿茶素没食子酸酯抑制EGFR突变型胶质母细胞瘤类器官缺氧诱导的癌症干细胞特性
Abdallah Fallah,Maellis Payet-Desruisseaux,Alain Zgheib et al.
Abdallah Fallah et al.
Background: Preventing the emergence and persistence of cancer stemness represents a promising strategy to reduce tumor aggressiveness and therapeutic failure. Cancer stem cells (CSCs), which contribute significantly to therapy resistance, ...
COL6A2 drives clear cell renal cell carcinoma progression via integrin-dependent modulation of Wnt/β-catenin signaling [0.03%]
COL6A2通过整合素依赖性调节Wnt/β-连环蛋白信号促进透明细胞肾细胞癌进展
Xing Ji,Yongyang Yun,Zhenpeng Zhu et al.
Xing Ji et al.
Introduction: The mechanistic role of COL6A2, an extracellular matrix protein, in clear cell renal cell carcinoma (ccRCC) is largely unexplored. This study aimed to investigate COL6A2 expression, its prognostic value, biological functions, ...
Koichi Jinushi,Yoshinori Hayashi,Koichi Morishita et al.
Koichi Jinushi et al.
Background: Gastric cancer remains one of the most common causes of cancer death, with a notably high incidence in East Asian countries. Regulatory T cells (Tregs) suppress antitumor immunity in the tumor microenvironment, and recent studie...