Selective sensitivity of betel nut-related oral squamous cell carcinoma to evodiamine through cell cycle arrest, growth inhibition and apoptosis induction [0.03%]
通过细胞周期阻滞、生长抑制和诱导凋亡选择性敏感地针对嚼食槟榔相关的口腔鳞状细胞癌的吴茱萸碱作用
Yin-Che Lu,Kai-Liang Tang,Chih-Hsien Liao et al.
Yin-Che Lu et al.
Head and neck cancer, particularly oral squamous cell carcinoma (OSCC), remains a major global health burden, with especially high incidence and mortality in Taiwan due to the widespread habit of betel quid chewing. Betel nut mediated OSCC ...
Integrative bulk and single-cell transcriptomic analysis identify an ac4C-related signature in lung adenocarcinoma [0.03%]
整合bulk和单细胞转录组分析鉴定出与肺腺癌相关的ac4C标志物
Shuo Wang,Changqing Yang,Xingkai Wang et al.
Shuo Wang et al.
Background: N4-acetylcytidine (ac4C) RNA modification is a critical epitranscriptomic regulator of cancer progression, yet its specific biological functions and regulatory patterns in lung adenocarcinoma (LUAD) remain poo...
A digital polymerase chain reaction method targeting non-recombined T-cell receptor sequences aids in diagnosing primary cutaneous T-cell lymphomas [0.03%]
靶向未重组T细胞受体序列的数字聚合酶链反应方法有助于诊断原发性皮肤T细胞淋巴瘤
Chien-Chin Chen,Cheng-Lin Wu,Bo-Jiun Tzeng et al.
Chien-Chin Chen et al.
Background: Diagnosing primary cutaneous T-cell lymphoma (PCTCL) relies on the comprehensive evaluation of clinical presentation, histopathology, immune profile, and molecular testing. Regarding molecular testing, the BIO...
tsRNA's Biological Function and its Potential Application in Disease Diagnosis and Prognosis [0.03%]
tsRNA的生物学功能及其在疾病诊断和预后中的潜在应用
Congcong Tang,Qi Tang,Siyuan Tang et al.
Congcong Tang et al.
Under physiological conditions, tsRNAs regulate mRNA transcription, reverse transcription, and protein translation to mediate cell apoptosis, cell cycle, and epigenetic regulation. Pathogenic tsRNAs are disease-specific or disease-related t...
Association of DNA damage response gene polymorphisms with treatment response and prognosis in acute myeloid leukemia [0.03%]
DNA修复基因多态性与急性髓系白血病治疗反应和预后的关联研究
Amin Zhang,Hanyang Wu,Wancheng Liu et al.
Amin Zhang et al.
The potential functional Single Nucleotide Polymorphism (SNPs) of DNA Damage Response (DDR)-related genes may influence AML aggressiveness and clinical outcomes through regulating genomic stability. However, systematic evaluation of functio...
Single-Cell-Derived Malignant Epithelial Programs Define Prognostic Risk and Therapeutic Vulnerability in Ovarian Cancer [0.03%]
单细胞衍生的恶性上皮程序可定义卵巢癌的预后风险和治疗脆弱性
Jingwen Si,Hanbo Li,Han Zhang et al.
Jingwen Si et al.
Background: Ovarian cancer (OV) is characterized by pronounced intratumoral heterogeneity and unfavorable clinical outcomes, yet clinically applicable biomarkers for risk stratification remain limited. Although bulk trans...
Cell-Specific DNA Methylation Markers in Plasma cfDNA Reveal Diagnostic Potential for Head and Neck Cancer [0.03%]
基于血浆游离DNA的细胞特异性甲基化标志物可揭示其在头颈鳞癌诊断中的潜力
Tianci Wang,Fei Han,Yuxuan She et al.
Tianci Wang et al.
Purpose: Head and neck cancer ranks as the seventh most common type of cancer worldwide. For patients diagnosed at advanced stages, the five-year survival rate remains below 40%, underscoring the urgent need for early det...
Long-Term Empagliflozin Treatment (50 Days) Attenuates Protease Activity, Migration, and Stemness-Associated Phenotypes in BFTC-909 Renal Pelvis Transitional Cell Carcinoma Cells [0.03%]
恩格列净长期治疗（50天）可减弱BFTC-909肾盂移行细胞癌细胞的蛋白酶活性、迁移能力和干细胞相关表型
Yi-Hsun Lee,Pei-Ni Chen,Yi-Hsien Hsieh et al.
Yi-Hsun Lee et al.
Empagliflozin is a sodium-glucose cotransporter 2 inhibitor widely prescribed for the treatment of type 2 diabetes mellitus. It promotes urinary glucose excretion by inhibiting renal glucose reabsorption. Although empagliflozin has been wid...
Arteannuin B Induces Ferroptosis in Colorectal Cancer Cells via GDF15/HMGCS1/GPX4 Axis [0.03%]
Arteannuin B通过GDF15/HMGCS1/GPX4轴诱导结直肠癌细胞铁死亡
Xiaozheng Ou,Jinghong Xu,Yuting Jin et al.
Xiaozheng Ou et al.
Purpose: Drug resistance in colorectal cancer (CRC) necessitates novel therapeutic strategies. This study investigated whether arteannuin B, a sesquiterpene lactone from Artemisia annua, induces ferroptosis in CRC cells a...
A Prognostic Risk Model for Hepatocellular Carcinoma Integrating Ferroptosis and Metabolic Reprogramming Signatures [0.03%]
整合铁死亡和代谢重编程特征的肝细胞癌预后风险模型
Hao Ling,Yanzhu Hu
Hao Ling
Background: Hepatocellular carcinoma (HCC) continues to impose a heavy global health burden, with high incidence and mortality. The disease is highly heterogeneous and is commonly detected at late stages, which compromise...