Evidence of aberrant DNA damage response signalling but normal rates of DNA repair in dividing lymphoblasts from patients with schizophrenia [0.03%]
精神分裂症患者增殖性淋巴母细胞中异常DNA损伤反应信号但正常的DNA修复速率的证据
Vibeke Sørensen Catts,Stanley Victor Catts,Assen Jablensky et al.
Vibeke Sørensen Catts et al.
Objectives: Cancer incidence in schizophrenia is not increased commensurate with higher rates of risk exposures. Here we report an investigation of the DNA damage response, an anti-tumorigenic defence, in immortalised lym...
The genetic blueprint of major depressive disorder: contributions of imaging genetics studies [0.03%]
遗传蓝图与重度抑郁障碍：影像遗传学研究的贡献
Christian Scharinger,Ulrich Rabl,Lukas Pezawas et al.
Christian Scharinger et al.
Objectives: To review neuroimaging intermediate phenotypes of MDD and their relation to genetic risk variants. Methods: A systematic li...
Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus [0.03%]
钠丁酸（HDAC抑制剂）的抗抑郁作用及其在大鼠海马中的分子机制研究
Yosuke Yamawaki,Manabu Fuchikami,Shigeru Morinobu et al.
Yosuke Yamawaki et al.
Objectives: Epigenetic mechanisms, such as changes in gene expression resulting from chromatin remodeling through histone acetylation, have been implicated in the pathophysiology of depression. However, the antidepressant...
Frontopolar cortical inefficiency may underpin reward and working memory dysfunction in bipolar disorder [0.03%]
额极皮层效率下降可能是双相情感障碍患者奖赏及工作记忆功能异常的机制
Jigar Jogia,Danai Dima,Veena Kumari et al.
Jigar Jogia et al.
Objectives: Emotional dysregulation in bipolar disorder is thought to arise from dysfunction within prefrontal cortical regions involved in cognitive control coupled with increased or aberrant activation within regions en...
Increased familiarity of intellectual deficits in early-onset schizophrenia spectrum disorders [0.03%]
早期青春型精神分裂症谱系障碍中智力缺陷的熟知度提高
Ximena Goldberg,Mar Fatjó-Vilas,M José Muñoz et al.
Ximena Goldberg et al.
Objectives: Early-onset schizophrenia is considered to be neurobiologically similar to adult-onset forms, although it represents a more severe expression of the disorder. In the present study, we explored putative larger ...
Modified magnesium and lipoproteins in children with attention deficit hyperactivity disorder (ADHD) [0.03%]
改良镁剂与注意缺陷多动障碍患儿脂蛋白的改变
Gisela Irmisch,Johannes Thome,Olaf Reis et al.
Gisela Irmisch et al.
Objective: Polyunsaturated fatty acids (PUFAs) have shown to be helpful in the therapy of ADHD. Various stabilizing co-factors may contribute to this effect, as like magnesium (Mg). Mg supports fatty acid enzyme activity ...
Associations of cytokine gene polymorphisms with post-stroke depression [0.03%]
细胞因子基因多态性与卒中后抑郁的关联研究
Jae-Min Kim,Robert Stewart,Sung-Wan Kim et al.
Jae-Min Kim et al.
Objectives: Inflammatory cytokines are implicated in the pathophysiology of both stroke and depression, and their production is influenced by the transcriptional activity of particular gene polymorphisms. We hypothesised ...
Enhanced brain responsiveness during active emotional face processing in obsessive compulsive disorder [0.03%]
强迫症患者在主动处理情绪面孔时大脑反应性增强
Narcís Cardoner,Ben J Harrison,Jesús Pujol et al.
Narcís Cardoner et al.
OBJECTIVES. The abnormal processing of emotional stimuli is common to a variety of psychiatric disorders. Specifically, patients with prominent anxiety symptoms generally overreact to emotional cues, which has been linked to increased amygd...
ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype [0.03%]
ANK3，CACNA1C和ZNF804A基因变异与双向障碍及精神病亚型的关系
Tristram A P Lett,Clement C Zai,Arun K Tiwari et al.
Tristram A P Lett et al.
OBJECTIVES. The ANK3, CACNA1C and ZNF804A genes have been implicated in both bipolar disorders (BPD) and schizophrenia (SCZ). It has been suggested that BPD with psychosis may be a clinical manifestation of genes overlapping between BPD and...