Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder [0.03%]
边缘型人格障碍患者在恐惧加工过程中的内侧前额叶功能异常和杏仁核反应持续时间延长
Susanne Kamphausen,Patricia Schröder,Simon Maier et al.
Susanne Kamphausen et al.
Objectives: Affective dysregulation is a clinical hallmark of borderline personality disorder (BPD). This study used an instructed fear task combined with functional MRI (fMRI) and skin conductance response (SCR) to test ...
Candidate system analysis in ADHD: evaluation of nine genes involved in dopaminergic neurotransmission identifies association with DRD1 [0.03%]
注意缺陷多动障碍候选系统分析：与多巴胺能神经传导有关的九个基因的评估发现DRD1相关性
Marta Ribasés,Josep Antoni Ramos-Quiroga,Amaia Hervás et al.
Marta Ribasés et al.
Objectives: Several pharmacological and genetic studies support the involvement of the dopamine neurotransmitter system in the aetiology of attention-deficit hyperactivity disorder (ADHD). Based on this information we eva...
Neuropeptide S receptor gene (NPSR) and life events: G × E effects on anxiety sensitivity and its subdimensions [0.03%]
神经肽S受体基因(NPSR)与生活事件：G×E效应在焦虑敏感性及其亚维度上的表现
Benedikt Klauke,Jürgen Deckert,Peter Zwanzger et al.
Benedikt Klauke et al.
Objectives: The pathogenesis of anxiety is assumed to be interactively influenced by genetic and environmental factors. Thus, a gene-environment interaction (G × E) study of the neuropeptide S receptor gene (NPSR) A/T po...
FoxP2 is significantly associated with schizophrenia and major depression in the Chinese Han population [0.03%]
FoxP2基因与汉族人群的精神分裂症和抑郁症显著相关性研究
Tao Li,Zhen Zeng,Qian Zhao et al.
Tao Li et al.
Objectives: The FoxP2 gene, located on 7q31, encodes a transcription factor. It was first discovered through investigations of a large multigenerational family (the KE family) with a rare severe speech and language disord...
Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder [0.03%]
双相情感障碍、精神分裂症和重大抑郁障碍的分子遗传重叠
Thomas G Schulze,Nirmala Akula,René Breuer et al.
Thomas G Schulze et al.
Objectives: Genome-wide association studies (GWAS) in complex phenotypes, including psychiatric disorders, have yielded many replicated findings, yet individual markers account for only a small fraction of the inherited d...
Rebecca Lyddon,Andrew J Dwork,Mehdi Keddache et al.
Rebecca Lyddon et al.
Objectives: mRNA for serotonin 2C receptor (5-HT(2C)R) undergoes editing which results in numerous isoforms. More highly edited isoforms exhibit decreased function. We recently found greater 5-HT(2C)R editing in suicide v...
FGFR2 is associated with bipolar disorder: a large-scale case-control study of three psychiatric disorders in the Chinese Han population [0.03%]
FGFR2与双相情感障碍相关性研究——汉族人群三个精神病学病例对照的大样本研究
Ti Wang,Zhen Zeng,Zhiwei Hu et al.
Ti Wang et al.
Objectives: Repetitive linkage analyses have indicated 10q25-q26 as a shared risk region for schizophrenia (SCZ) and bipolar disorder (BPD). A genome-wide association study and follow-up recently identified a significant ...
Neurotransmitter systems and neurotrophic factors in autism: association study of 37 genes suggests involvement of DDC [0.03%]
自闭症的神经递质系统和神经营养因子的研究：37个基因的相关研究提示DDC基因的作用
Claudio Toma,Amaia Hervás,Noemí Balmaña et al.
Claudio Toma et al.
Objectives: Neurotransmitter systems and neurotrophic factors can be considered strong candidates for autism spectrum disorder (ASD). The serotoninergic and dopaminergic systems are involved in neurotransmission, brain ma...
Preliminary evaluation of clinical outcome and safety of ketamine as an anesthetic for electroconvulsive therapy in schizophrenia [0.03%]
氯胺酮在精神分裂症电休克治疗中麻醉效果和安全性的初步研究
Laura Kranaster,Carolin Hoyer,Christoph Janke et al.
Laura Kranaster et al.
Objectives: Electroconvulsive therapy (ECT) is an effective and safe option in the treatment of affective disorders and schizophrenia. One parameter known to influence ECT treatment efficacy is the choice of narcotic, and...
Functional investigation of a schizophrenia GWAS signal at the CDC42 gene [0.03%]
精神分裂症基因组范围关联信号通路的机能研究（CDC42基因）
William P Gilks,Matthew Hill,Michael Gill et al.
William P Gilks et al.
Objectives: SNP rs2473277 upstream of the cell division cycle 42 (CDC42) gene was associated with schizophrenia in a recent genome-wide association study (GWAS). Reduced expression of CDC42 in schizophrenia has previously...