Investigation of the role of the LC3 conjugation system in autophagy for human reward system reactivity [0.03%]
LC3结合系统在人类奖赏系统反应的自噬作用中的角色研究
Jens Treutlein,Bernd Krämer,Oliver Gruber
Jens Treutlein
Objectives: The dopaminergic reward system is involved in the aetiology of psychiatric disorders, and autophagy has been suggested to interfere with dopamine release. LC3 conjugation plays a key role in autophagy and comp...
The cholinergic anti-inflammatory reflex as a function of depression severity in adolescent non-suicidal self-injury [0.03%]
胆碱能抗炎反射在青少年非自杀性自伤中的作用及严重程度的影响
Thomas P Nguyen,Luise Baumeister-Lingens,Anna Markser et al.
Thomas P Nguyen et al.
Objectives: Non-suicidal self-injury (NSSI) is associated with pro-inflammatory states. The cholinergic anti-inflammatory reflex is a neural pathway, modulating the body's inflammatory response. This study aimed to invest...
Escape genes from X-chromosome inactivation: new insights into candidate genes for intellectual disability in females [0.03%]
逃逸X染色体失活的基因：获得智力障碍女性候选基因的新见解
Lizandra Abreu de Oliveira,Rafael Mina Piergiorge,Cíntia Barros Santos-Rebouças
Lizandra Abreu de Oliveira
Objectives: X-chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals. Given that the Xchromosome harbours numerous genes implicated in cognitive function, variants in these genes can affect neu...
Expression profile of the ADHD risk gene ADGRL3 during human neurodevelopment and the effects of genetic variation [0.03%]
ADHD风险基因ADGRL3在人类神经发育过程中的表达谱及其遗传变异的影响
Rhiannon Victoria McNeill,Matthias Nieberler,Zora Schickardt et al.
Rhiannon Victoria McNeill et al.
Objectives: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, with symptoms including hyperactivity, inattention and impulsivity. Moreover, ADHD persists into adulthoo...
Resting-state functional connectivity within the reward system mediates subcortical integration during erotic stimulus processing [0.03%]
奖赏系统静息态功能连接在性刺激加工过程中介导皮下整合作用机制研究
Carolina Fiederer,Tara Chand,Louise Martens et al.
Carolina Fiederer et al.
Objectives: Erotic stimuli lead to activations in various brain regions, including the reward system. Several neuroimaging studies have investigated neurofunctional activations during visual erotic stimulation. Little res...
Diagnostic potential of P2X7, NACHT, and iL-6 as immune biomarkers in bipolar disorder [0.03%]
P2X7，NACHT和iL-6作为双相情感障碍免疫生物标志物的诊断潜力
Magda Malewska-Kasprzak,Magdalena Sikorski,Monika Dmitrzak-Weglarz et al.
Magda Malewska-Kasprzak et al.
This study examines immune markers-P2X7, NACHT, and IL-6-as potential diagnostic and therapeutic biomarkers in Bipolar Disorder (BD). Among 120 participants (76 BD patients and 20 healthy controls), P2X7 levels were significantly elevated i...
Evaluation of retinal layer thickness in patients with bipolar disorder, their relatives, and healthy controls using optical coherence tomography [0.03%]
应用光学相干断层扫描技术评估双相障碍患者、其一级亲属及健康对照的视网膜厚度差异
Erbil Seven,Faruk Kurhan
Erbil Seven
Background: Bipolar disorder (BD) is a chronic psychiatric condition characterised by mood episodes and associated structural changes in the central nervous system. Optical coherence tomography (OCT) offers a non-invasive...
Altered cerebral functional activity and its associated genetic profiles underlying chronic insomnia disorder before and after treatment [0.03%]
慢性失眠障碍治疗前后大脑功能改变及遗传易感性研究
Leyi Zhang,Zhiguo Guo,Yiding Han et al.
Leyi Zhang et al.
Objectives: The resting-state cerebral functional activity underlying chronic insomnia disorder (CID) remains inconsistent, and the effects of pharmacotherapy on such activity are unclear. ...
Do serum endocannabinoid and N-acylethanolamine concentrations reflect their brain levels in two different rat stress models? [0.03%]
两种大鼠应激模型中血清内源性 cannabinoid 和 N-乙醇胺浓度是否反映其脑内的水平？
Ruhan Deniz Topuz,Buse Cevık,Kursat Guler et al.
Ruhan Deniz Topuz et al.
Background: Although the brain is not the only source of circulating endocannabinoids and their levels can be affected by many factors, it is underlined that serum endocannabinoid levels can be used as a biomarker in psyc...
Optimism moderates the relationship between inflammatory polygenic risk and major depressive disorder in U.S. Military veterans [0.03%]
乐观心态缓和了美国退伍军人中炎症多基因风险与重大抑郁症之间的关系
Ian C Fischer,Cassie Overstreet,Brenda Cabrera-Mendoza et al.
Ian C Fischer et al.
Objectives: Major depressive disorder (MDD) is a leading cause of disability, and chronic inflammation is a contributing factor to its onset and progression. This study examined the relationship between genetic predisposi...