Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer's Disease Research [0.03%]
来自TgF344-AD的研究模型在阿尔茨海默病研究中的见解
A Nataraj,K Blahna,K Ježek
A Nataraj
Alzheimer's disease (AD), a leading cause of dementia worldwide, is a multifactorial neurodegenerative disorder characterized by amyloid-beta plaques, tauopathy, neuronal loss, neuro-inflammation, brain atrophy, and cognitive deficits. AD m...
Assessment of Blood-Brain Barrier Permeability in a Cerebral Ischemia-Reperfusion Model in Rats; A Pilot Study [0.03%]
评估缺血再灌注大鼠模型中血脑屏障通透性的研究；一项初步研究报告
P Kozler,D Marešová,J Pokorný
P Kozler
Animal models are an important tool for studying ischemic mechanisms of stroke. Among them, the middle cerebral artery occlusion (MCAO) model via the intraluminal suture method in rodents is closest to human ischemic stroke. It is a model o...
High-Intensity Interval Training Increases Osteoarthritis-Associated Pain-Sensitive Threshold Through Reduction of Perineuronal Nets of the Medial Prefrontal Cortex in Rats [0.03%]
高强度间歇训练通过减少外侧膝状体周围神经网提高骨关节炎相关的痛阈值
X Zhang,F E Kong,C-S Lin et al.
X Zhang et al.
High-intensity interval training (HIIT) is considered an effective therapy strategy for improving chronic pain associated with osteoarthritis (OA). Perineuronal nets (PNNs) are specialized extracellular matrix structures in the cerebral cor...
Eicosapentaenoic Acid Triggers Phosphatidylserine Externalization in the Erythrocyte Membrane through Calcium Signaling and Anticholinesterase Activity [0.03%]
二十碳五烯酸通过钙信号和抗胆碱酯酶活性触发红细胞膜上的磷脂酰丝氨酸外翻
F H Alharthy,J Alsughayyir,M A Alfhili
F H Alharthy
Hemolysis and eryptosis contribute to anemia encountered in patients undergoing chemotherapy. Eicosapentaenoic acid (EPA) is an omega-3 dietary fatty acid that has anticancer potential by inducing apoptosis in cancer cells, but its effect o...
J Hendrych,M Bayer,P Havránek et al.
J Hendrych et al.
To evaluate vitamin D levels in children treated with fractures during the healing period. A four-year prospective study, including healthy children treated with diaphyseal fracture of femur or forearm bones. Vitamin D levels were examined ...
Hyperbaric Oxygen Promotes Chronic Wound Healing in Sprague-Dawley Rats by Inhibiting Pyroptosis [0.03%]
高压氧通过抑制细胞焦亡促进大鼠慢性伤口愈合
H Ma,X Wei,E Lin et al.
H Ma et al.
This study aimed to establish a rat model of chronic wounds to observe the effects of hyperbaric oxygen (HBO) on chronic wound repair and pyroptosis and explore the potential role of pyroptosis in the pathogenesis of chronic wounds. Sprague...
Adipokine Levels of RBP4, Resistin and Nesfatin-1 in Women Diagnosed With Gestational Diabetes [0.03%]
妊娠糖尿病女性患者脂肪细胞因子RBP4、抵抗素和Nesfatin-1水平变化的研究
V Kučerová,D Karásek,O Krystyník et al.
V Kučerová et al.
Gestational diabetes mellitus (GDM) is a common complication of pregnancy in which women without previously diagnosed diabetes develop chronic hyperglycemia during pregnancy. It is associated with a number of maternal and fetal/neonatal com...
Type 2 Diabetes, Obesity and Their Relation to the Risks of Thyroid Cancer [0.03%]
2型糖尿病、肥胖及其与甲状腺癌风险的关系
T Grimmichová,V Kukliková,B Bulanová et al.
T Grimmichová et al.
Objective: patients with type 2 diabetes (T2DM) and obesity are generally known to have increased risk of various types of cancer, though studies addressing associations between T2DM/obesity and thyroid cancer are inconcl...
Endothelial Dysfunction in the Tubule Area Accelerates the Progression of Early Diabetic Kidney Disease [0.03%]
tubule区域内皮功能障碍加速早期糖尿病肾脏疾病进展
W Zeng,D Ying,B Chen et al.
W Zeng et al.
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Therefore, understanding the molecular regulatory mechanisms underlying the pathogenesis of DKD is imperative. In this study, we aimed to explore the molecular m...
LDHA- Mediated Histone Lactylation Promotes the Nonalcoholic Fatty Liver Disease Progression Through Targeting The METTL3/ YTHDF1/SCD1 m6A Axis [0.03%]
依赖于LDHA介导的组蛋白乳酰化的非酒精性脂肪肝病进展：靶向METTL3/YTHDF1/SCD1甲基转移酶m6A轴
J Meng,C Yan,J Liu
J Meng
Nonalcoholic fatty liver disease (NAFLD) is characterized by elevated hepatic lipids caused by nonalcoholic factors, where histone lactylation is lately discovered as a modification driving disease progression. This research aimed to explor...