Glial Activation Enhances Spinal TRPV1 Receptor Sensitivity in a Paclitaxel Model of Neuropathic Pain [0.03%]
雪旺细胞活化增强紫杉醇诱导的外周神经病理性疼痛模型中TRPV1通道敏化的作用及机制研究
J Slepicka,J Palecek
J Slepicka
Paclitaxel (PTX), a commonly used chemotherapeutic, frequently leads to chemotherapy-induced peripheral neuropathy (CIPN), characterized by persistent pain and neuronal hypersensitivity. While its effects on peripheral nerves are well-docum...
Pathophysiology of Clopidogrel in Ischemic Stroke, Role of Platelet microRNAs [0.03%]
氯吡格雷在缺血性卒中中的发病机制及血小板微小核糖核酸的作用
T Mičaník,O Slabý,T Kvasnička et al.
T Mičaník et al.
Variation in response to clopidogrel represents a significant clinical challenge in patients with ischemic stroke. Genetic polymorphisms cytochrome P450 2C19 (CYP2C19) are a known cause of resistance to clopidogrel. Platelet microRNAs (miRN...
S Liu,K Daďová
S Liu
Astaxanthin is a natural, small-molecule compound with anti-inflammatory and antioxidant properties that has broad potential for use in alleviating exercise fatigue. This study investigated whether astaxanthin can attenuate the onset of fat...
Gut Hormone Levels During Mixed Liquid Meal Test in Short Bowel Syndrome, the Possible Influence on the Intestine Adaptation [0.03%]
短肠综合征混合液餐耐受试验中的胃激素水平变化及其对肠道适应的影响研究
J Krizova,P Trachta,M Mraz et al.
J Krizova et al.
Short bowel syndrome (SBS) is an intestinal disorder characterized by reduced length of the gut most due to intestinal resection, resulting in malabsorption, malnutrition, and water and electrolyte disturbances. Intestinal adaptation is a l...
Prevention of the Progression of lupus Nephritis in MRL/lpr Mice by Modulating miR-9-5p/Foxo1 Axis [0.03%]
通过调节miR-9-5p/Foxo1轴防治MRL/lpr鼠狼疮性肾炎进展
H Yan,W Tong
H Yan
MiR-9-5p is up-regulated in lupus nephritis (LN) patients and targets Foxo1 that is a protective factor against renal disorders. In the current study, the role of miR-9-5p/Foxo1 LN progression was assessed and the associated mechanism was e...
Protective Effects of Teucrium Polium Leaf Ethanolic Extract Against Nicotine-Induced Nephrotoxicity in Mice [0.03%]
丹参药用部位的比较及不同溶剂提取物对大鼠肝脏和肾脏的影响研究
A Alatawi,S Maodaa,S Alarifi et al.
A Alatawi et al.
This study aimed to examine the protective and antioxidant properties of a Teucrium polium leaf extract against acute kidney damage caused by nicotine in male mice. A total of 24 male Swiss albino mice were divided into four groups. The con...
Trimethylamine N-oxide Induced Chronic Kidney Injury by Triggering PANoptosis [0.03%]
N,N,N-三甲基氧化胺诱导PANoptosis级联反应导致慢性肾脏病模型小鼠肾损伤
D Shao,L Bai,Q Chen et al.
D Shao et al.
Trimethylamine N-oxide (TMAO) is involved in the development of kidney disease. However, the specific mechanism by which it leads to kidney injury is unclear. This study explored the role of regulated cell death in TMAO-induced kidney injur...
AGEs Inducing EPCs Apoptosis via ROS and p38 MAPK/JNK Pathways in Diabetic Vascular Complications [0.03%]
糖基化终产物通过ROS和p38MAPK/JNK信号通路诱导EPCs凋亡在糖尿病血管并发症中的作用
X Yang,Z Zhu,Z Li et al.
X Yang et al.
Endothelial progenitor cells (EPCs) promote blood-vessel repair, but their apoptosis worsens diabetes-related vascular damage. Although advanced glycation end products (AGEs) abound in diabetes, it remains unclear whether they trigger EPC a...
Analysis of Gene Expression Profiles Regulating Phenotypic Transformation of Vascular Smooth Muscle Cells by Endothelial Cell-Derived Exosomes [0.03%]
内皮细胞源性外泌体调控血管平滑肌表型转化的基因表达谱分析研究
T Kang,X Li,S Hang et al.
T Kang et al.
To establish a co-culture cell model and implement high-throughput gene sequencing of exosomes, we preliminarily demonstrated that endothelial cell-derived exosomes play a role in modulating the phenotypic transformation of vascular smooth ...
Role of Carvedilol in Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells by Upregulating microRNA-145 Expression [0.03%]
卡维地洛通过上调microRNA-145表达抑制血管平滑肌细胞增殖和迁移的作用机制研究
G Yang,Z Zhang,X Ma et al.
G Yang et al.
The proliferation and migration of vascular smooth muscle cells (VSMCs) are the initial contributors to restenosis in patients undergoing percutaneous coronary intervention (PCI). MicroRNA-145 (miR-145) plays a significant role in this path...