Myocardial fibrosis, the silent instigator of diastolic dysfunction in patients with rheumatoid arthritis [0.03%]
类风湿关节炎患者心肌纤维化与隐匿性舒张功能障碍的关系
M Jalali,J Števlík,Y Jalali et al.
M Jalali et al.
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease associated with increased cardiovascular morbidity and mortality. Myocardial fibrosis, a key pathological consequence of prolonged inflammation, contributes to diastolic d...
The Effect of N-Acetylcysteine on Behavioral Sensitization to Methamphetamine in Mice [0.03%]
N-乙酰半胱氨酸对提高小鼠甲基苯丙胺诱导的行为敏感性的影响
A Máchalová,L Landa,J Máchal et al.
A Máchalová et al.
Behavioral sensitization is a phenomenon occurring after repeated administration of various psychotropic substances and it is characterized by gradually increasing response to the particular drug. It has been described for majority of addic...
Serum Glutathione and Malondialdehyde Levels as Predictors of Early Neurological Deficits and Short-Term Outcomes in Acute Cerebral Infarction [0.03%]
急性脑梗死患者早期神经功能缺损及近期预后相关血清谷胱甘肽和丙二醛水平预测价值分析
Y-X Wang,J-Y Wang,H Yang et al.
Y-X Wang et al.
This study investigates the association between serum glutathione (GSH) and malondialdehyde (MDA) levels and early neurological deficits and short-term outcomes in individuals with acute cerebral infarction (ACI). The study included 114 pat...
Protective Effects of Panax notoginseng Saponins on Cerebral Ischemia/Reperfusion Injury: Insights Into SIRT1/NRF2/HO-1 Pathway Activation [0.03%]
三七总皂苷通过激活SIRT1/NRF2/HO-1信号通路对抗脑缺血再灌注损伤的保护作用研究
J Wu,X Chen,X Lin et al.
J Wu et al.
Stroke and cerebral ischemia/reperfusion (IR) injury are severe conditions characterized by impaired blood flow to the brain, leading to tissue infarction and neurological impairments. Panax notoginseng saponins (PNS) have displayed various...
Hirudin Alleviates Early Brain Injury After Subarachnoid Hemorrhage in Rats via Regulating NLRP3 Inflammasome-Mediated Pyroptosis [0.03%]
蚯蚓素通过调节NLRP3炎症小体介导的pyroptosis来缓解SD大鼠蛛网膜下腔出血后的早期脑损伤
M Pan,H Chen,Y Zhai et al.
M Pan et al.
Subarachnoid hemorrhage (SAH) is a critical neurological emergency and one of the leading causes of stroke. Neuronal demise serves as the primary factor contributing to early brain injury (EBI) following SAH. This study aims to investigate ...
Podophyllotoxin Alleviates DSS-Induced Ulcerative Colitis via PI3K/AKT Pathway Activation [0.03%]
Podophyllotoxin通过激活PI3K / AKT信号通路缓解DSS诱导的溃疡性结肠炎
T Li,X Wang,J Wang
T Li
This study systematically evaluated the therapeutic effects of podophyllotoxin in a DSS-induced mouse model of ulcerative colitis. A total of 374 podophyllotoxin-related targets were identified through database screening, and by intersectin...
Key Ferroptosis Genes and their Predictive and Diagnostic Value in Fanconi Anemia [0.03%]
凯摩擦性小体基因及其在范可尼贫血预测和诊断中的作用
C Meng,L Huang,H Huang et al.
C Meng et al.
Fanconi anemia (FA) and ferroptosis both affect tumor-related processes. However, few studies have reported on genetic associations between FA and ferroptosis. Our study evaluated the usefulness of genes related to ferroptosis in predicting...
L Ye,H Wang,H Du et al.
L Ye et al.
Whether the lung is a primary site of platelet (PLT) production is still disputed. To address this question, PLT parameters in blood before and after pulmonary circulation in humans, rats, and rabbits were assessed by automatic hematology a...
M Lukáčová,P Mitro,Z Lazúrová et al.
M Lukáčová et al.
Orthostatic intolerance (OI) is defined as the development of characteristic symptoms while standing, which significantly improve by recumbency. The most common forms are vasovagal syncope (VVS), orthostatic hypotension, and postural orthos...
Agonist-Triggered Ca2+ Release From Functionally Connected Endoplasmic Reticulum and Lysosomal Ca2+ Stores in bEND.3 Endothelial Cells [0.03%]
与内质网和溶酶体功能相连的钙离子贮存在bEND.3血管内皮细胞中通过激动剂触发的钙离子释放出来
Cing-Yu Chen,Yu-Jen Chen,Cheng-An Wang et al.
Cing-Yu Chen et al.
Endoplasmic reticulum (ER) and lysosomes are physiologically active, physically and functionally connected intracellular Ca2+ stores. In this study we investigated agonist-triggered Ca2+ release from these two stores in mouse microvascular ...