Triptolide from Tripterygium wilfordii Suppresses Glycolysis and Induces Cuproptosis via the HK2/DLAT Signaling Pathway in Colorectal Cancer [0.03%]
雷公藤内酯通过HK2/DLAT信号通路抑制糖酵解并诱导铜死亡从而抑制结直肠癌
Hui-Hui Liang,Lu-Lu Jia,Ke Tang et al.
Hui-Hui Liang et al.
Colorectal cancer (CRC) exhibits high mortality due to tumor cell dissemination. Surgical resection combined with chemotherapy is the primary treatment, but chemoresistance often limits its efficacy against metastasis. Cuproptosis, a novel ...
Research Progress of Traditional Chinese Medicine in Regulating Ferroptosis Related to Digestive System Tumors [0.03%]
中医药调控消化系统肿瘤铁死亡研究进展
Xinyu Cai,Xueer Zheng,Jiahua Mao et al.
Xinyu Cai et al.
Ferroptosis is a novel type of cell death that depends on iron ions and lipid peroxidation. An increasing number of studies have shown that ferroptosis can inhibit the progression of digestive system tumors, enhance the sensitivity of tumor...
Codonopsis Pilosula (Dangshen) Alleviates Ulcerative Colitis Through Activation of the Aromatic Hydrocarbon Receptor Signaling Pathway by the Gut Bacterium Alistipes Onderdonkii and Its Metabolite, 5-HIAA [0.03%]
北沙参通过激活肠道菌Ondermontii拟杆菌和其代谢产物5-羟色胺的芳香烃受体信号通路来缓解溃疡性结肠炎
Qian Yang,Wentai Pang,Lin Ma et al.
Qian Yang et al.
Ulcerative colitis (UC) is a growing global health concern, but there remains a lack of natural food sources and multi-targeted drugs to effectively it. Codonopsis pilosula (dangshen, DS), a medicinal food used in traditional Chinese medici...
The Role of Traditional Chinese Medicine in the Management of Polyploid Giant Cancer Cells [0.03%]
中医药在治疗多倍体巨大型癌细胞中的作用
Yanyuan Zhou,Tungyi Lin,Tingan Chiang et al.
Yanyuan Zhou et al.
Cancer causes millions of deaths globally every year. At its later stages, cancers are primarily treated with systemic therapies which do not provide an effective cure; the remaining cancer cells ultimately acquire drug resistance, relapse,...
Quercetin Alleviates Endothelial Dysfunction in Atherosclerosis by Inhibiting Ferroptosis Through PACS2/HMOX-1 Pathway [0.03%]
染料木黄酮通过PACS2/HMOX-1信号通路抑制铁死亡从而改善动脉粥样硬化内皮功能障碍
Hai-Jiao Long,Quan-Jun Liu,Shi-Ying Qin et al.
Hai-Jiao Long et al.
Atherosclerosis is a leading cause of worldwide cardiovascular morbidity and mortality, and endothelial ferroptosis has emerged as a key mechanism in driving vascular injury. This study aimed to investigate whether quercetin (QCT), a natura...
Research Progress on the Mechanism of Astragaloside IV for Treating Myocardial Infarction [0.03%]
黄芪苷IV治疗心肌梗死的机制研究进展
Bin Li,Yijia Liu,Guiping Hu et al.
Bin Li et al.
Myocardial infarction (MI) is a severe cardiovascular disorder characterized by an irreversible myocardial necrosis caused by acute ischemia. The typical manifestations of MI include persistent substernal chest pain, dyspnea, nausea, vomiti...
Cepharanthine Triggers Ferroptosis in Gastric Cancer by PINK1/FUNDC1-Mediated Mitophagy-Dependent GPX4 Degradation [0.03%]
cepharanthine通过PINK1/FUNDC1介导的线粒体自噬依赖性GPX4降解触发胃癌铁死亡
Fubo Jing,Bing Yan,Chunlan Liu et al.
Fubo Jing et al.
Cepharanthine (CEP), a natural compound derived from the plant Stephania cephalantha Hayata, demonstrates pharmacological properties including anti-inflammatory, immuno-regulatory, antiviral, antitumor and antiparasitic effects. Due to its ...
Rhein Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting the Microglial NLRP3 Inflammasome/Pyroptosis Axis and Regulating Microglial M1/M2 Phenotypes [0.03%]
Rhein通过抑制微胶质细胞NLRP3炎性小体/焦亡轴及调节M1/M2表型治疗脑缺血再灌注损伤
Xun Li,Yan Li,Wei-Peng Jing et al.
Xun Li et al.
The activation of the NLRP3 inflammasome is critical to inducing microglial activation and pyroptosis following cerebral ischemia/reperfusion (I/R). Suppressing the neurotoxicity of activated microglia has become an effective approach for t...
Molecular Mechanisms and Therapeutic Potentials of Triptolide in Autoimmune Diseases: Advances and Challenges [0.03%]
三氧化二砷在自身免疫疾病分子机制及治疗潜力：进展与挑战
Junning Zhang,Fangying Huang,Yujiao Xu et al.
Junning Zhang et al.
The global incidence and prevalence of autoimmune diseases are increasing, and there is thus a need to develop novel, effective, and affordable therapeutic agents for autoimmune diseases. Triptolide (TP), a bioactive diterpenoid epoxide iso...
Research Progress on Combination Therapies Based on PD-1/PD-L1 Blockade Against Malignancies and the Adjuvant Effects of Traditional Chinese Medicine [0.03%]
基于PD-1/PD-L1阻断的恶性肿瘤联合疗法研究进展及中药辅助效应探讨
Juntao Wang,Shunchao Zhang,Yuhan Wei et al.
Juntao Wang et al.
Programmed death (PD-1) is an important immune checkpoint receptor expressed on the surface of T cells, B cells and natural killer (NK) cells. PD-L1 (B7-H1) is a critical ligand for PD-1, and is widely expressed in a variety of cancer cells...