Artemisinin Attenuates Aβ1-42 Aggregation via the CaMK IV/PKA-CREB-Ace-H4 Cascade in Neuronal Cultures and 3xTg-AD Models [0.03%]
Yitian Chen,Lijun Ge,Philip Lazarovici et al.
Yitian Chen et al.
Alzheimer's disease (AD), a progressive neurodegenerative disease with a rising global prevalence, is characterized by amyloid-β (Aβ) aggregation, tau hyperphosphorylation, inflammation, oxidative damage, and neuronal apoptosis. Studies h...
Bufalin Induces Ferroptosis in Triple-Negative Breast Cancer via Inhibition of the NRF2/HO-1/GPX4 Pathway [0.03%]
Ji-Ying Zhou,An-Xin Wang,Min Jin et al.
Ji-Ying Zhou et al.
Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer characterized by poor prognosis and limited therapeutic options, remains a major clinical challenge. Bufalin, a principal bioactive component of Venenum Bufo...
Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury by Suppressing Neutrophil Extracellular Traps and Ferroptosis in Brain Microvascular Endothelial Cells [0.03%]
Qian Xiao,Xin-Quan Deng,Biao Tang
Qian Xiao
Panax notoginseng saponins (PNS), the chief saponin components of the traditional Chinese medicine Panax notoginseng, are known to ameliorate the outcomes of ischemic stroke (IS), primarily by mitigating inflammatory responses, enhancing mi...
Triptolide Improves Rheumatoid Arthritis by Regulating M1/M2 Balance Through the miR-223/CREBZF Axis [0.03%]
Xiao-Bao Liu,Ying-Xing Xiang,Jia-Hao Yang et al.
Xiao-Bao Liu et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation and progressive joint damage. This study investigated the role of microRNA-223 (miR-223) in RA and evaluated the therapeutic effects of tript...
Berberine from Traditional Chinese Medicine in Liver Diseases: From Steatosis to Fibrosis and Hepatic Malignancies [0.03%]
Hongxia He,Shuyun Wu,Jiazhi Yi
Hongxia He
Berberine (BBR), the core alkaloid of the traditional Chinese medicine Coptis chinensis (Huanglian), exhibits a notable pharmacological paradox: it possesses an oral bioavailability of less than 1% yet exerts broad therapeutic effects acros...
Promotion of Angiogenesis with American Ginseng (Panax quinquefolius) After Myocardial Infarction via Targeting DNMT3b-Mediated DNA Methylation and Activating the Notch1/USP5/STAT3 Signaling Axis [0.03%]
通过靶向DNMT3b介导的DNA甲基化和激活Notch1/USP5/STAT3信号轴促进美洲人参（Panax quinquefolius）心肌梗死后的血管生成
Jun-Han Yao,Yu Bi,Gang-Tao Bu et al.
Jun-Han Yao et al.
Myocardial infarction (MI) necessitates the promotion of angiogenesis to improve prognosis. Panax quinquefolius saponins (PQS), bioactive constituents of a medicinal and edible homologous plant, are known for their cardiovascular benefits, ...
Flaxseed and Linusorb Synergistically Ameliorate Menopausal Symptoms Through Non-Hormonal Activation of Estrogen Receptors and Suppression of Osteoclastogenesis [0.03%]
亚麻籽和木酚素通过非激素激活雌激素受体和抑制破骨细胞生成协同改善更年期症状
Won Young Jang,Ji Hye Yoon,Seul Bi Lee et al.
Won Young Jang et al.
Phytoestrogens derived from natural products have emerged as potential alternatives to hormone replacement therapy (HRT) for alleviating menopausal symptoms with reduced adverse effects. However, the therapeutic potential and mechanistic ba...
Notoginsenoside R1 Alleviates Acetaminophen-Induced Liver Injury via MAPK/mTOR-Mediated Autophagy [0.03%]
诺高辛苷R1通过MAPK/mTOR介导的自噬缓解乙酰氨基酚致肝损伤
Shuangjiang Li,Zhipeng Liu,Guandong Pan et al.
Shuangjiang Li et al.
Acetaminophen (APAP) overdose is a leading cause of acute liver injury (ALI), yet effective therapeutic options remain limited. Although notoginsenoside R1 (NGR1) is a major bioactive saponin isolated from Panax notoginseng with established...
Anti-Malignancy and Anti-Inflammation Properties of Emodin, an Essential Constituent in Popular Laxative Botanicals [0.03%]
大黄䗪虫丸中有效成分番泻叶苷抗肿瘤及抗炎作用研究
Meng Wang,Xiankang Zhang,Yanrong Huang et al.
Meng Wang et al.
The rhubarb root and the senna leaf are two commonly used laxative herbs for functional constipation, containing dianthrones and free anthraquinones. As a free anthraquinone, emodin is a crucial constituent isolated from laxative botanicals...
Ginsenoside Rg3 in Cancer Therapy: Pharmacokinetics, Molecular Mechanisms, and Synergistic Combinations [0.03%]
红参皂苷Rg3在癌症治疗中的药代动力学、分子机制及其协同作用研究
Yue Cui,Jingming Li,Chunyan Liu et al.
Yue Cui et al.
Ginsenoside Rg3, a rare protopanaxadiol-type saponin enriched during the heat processing of Panax ginseng, has attracted increasing attention as a multitarget anticancer agent. This systematic review examines the anticancer potential of Rg3...