Astragaloside IV Attenuates Heart Failure by Modulating SCAD/DJ-1/SIRT1/FOXO3a Signaling Axis [0.03%]
Astragaloside IV通过调节SCAD/DJ-1/SIRT1/FOXO3a信号轴缓解心力衰竭
Yu-Hong Cao,Ya-Xin Duan,Jie-Ye Qin et al.
Yu-Hong Cao et al.
As the key functioning element of the traditional Chinese medicinal herb Astragalus, Astragaloside IV (AS-IV) has potentially protective effects on heart failure (HF). Short-chain Acyl-CoA dehydrogenase (SCAD) is a critical enzyme in fatty ...
Cinnamaldehyde Ameliorates Ischemic Heart Failure by Targeting USP18 to Inhibit [Formula: see text]-Adrenergic Receptor Ubiquitination and Suppress TAK1/NF-[Formula: see text]B Signaling Pathway [0.03%]
肉桂醛通过靶向USP18改善心肌缺血诱导的心力衰竭：抑制β肾上腺素受体泛素化及TAK1/NF-κB信号通路
Zhao Chen,Xiaoyu Tian,Zhongqiu Liu et al.
Zhao Chen et al.
Cinnamaldehyde, a bioactive constituent derived from Cinnamomum cassia Presl, exhibits diverse pharmacological effects, including vasodilatory and antihypertensive properties. However, its pharmacological impact and underlying mechanism con...
Mechanism of Quercetin and Luteolin on Colon Cancer Metastasis: Network Pharmacological Study and Experimental Validation [0.03%]
基于网络药理学的檞皮素和黄芩素抑制结肠癌转移机制研究及实验验证
Shi-Wei Wu,Jin-Fang Chen,Zi-Man Shi et al.
Shi-Wei Wu et al.
Quercetin (QCT) and luteolin (LTL) are anticancer herbal compounds. However, their combined effects on colon cancer metastasis remain unknown. This study explored the effects and mechanisms of QCT and LTL against colon cancer metastasis usi...
Restoring Homeostatic Balance: Advances in Traditional Chinese Medicine for Rheumatoid Arthritis [0.03%]
恢复平衡：传统中医在治疗类风湿关节炎中的新进展
Yuhong Xiang,Aihong Yang,Cong Guo et al.
Yuhong Xiang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease with inflammation-mediated joint damage. Its pathogenesis involves synergistic impairment of multiple physiological balances, including immune cell subset dysregulation, abnormal inf...
Active Constituents of Magnolia officinalis in Cancer Management: Molecular Mechanisms and Therapeutic Potential [0.03%]
厚朴在癌症管理中的活性成分：分子机制和治疗潜力
Jiao Xia,Youqin Zeng,Yuting Ye et al.
Jiao Xia et al.
The global incidence and mortality of cancer continue to increase, and various chemotherapeutic agents, while highly effective, are associated with serious side effects like immunosuppression, metabolic dysfunction, and drug resistance. As ...
Natural Products for Alzheimer's Disease: A New Twist Impacting Ferroptosis [0.03%]
阿尔茨海默病的天然产物：影响铁死亡的新思路
Yaqiao Yi,Pu Jia,Peipei Xie et al.
Yaqiao Yi et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline. Despite significant advances in AD research, effective disease-modifying therapies remain unavailable. In recent years, ferroptosis has...
Hongli Huang,Linhong Wang
Hongli Huang
With global resources becoming increasingly strained, the development of novel sustainable resources has become particularly important. Spirulina has attracted considerable attention due to its exceptional nutritional value, abundant bioact...
Research Progress on the Molecular Mechanisms of Cordycepin in Modulating Inflammation [0.03%]
虫草素调控炎症分子机制研究进展
Yali Zhao,Shihao Zheng,Mengxue Liu et al.
Yali Zhao et al.
Cordycepin is a bioactive compound isolated from the Cordyceps fungi. It is structurally analogous to adenosine and possesses potent anti-inflammatory and immunomodulatory properties. Its anti-inflammatory effects are mainly mediated by reg...
Acupuncture for Neuropathic Pain: Mechanisms, Clinical Efficacy and Future Perspectives [0.03%]
神经病理性疼痛的针刺治疗：机制、临床疗效和未来前景
Yu-Hsuan Chen,Sheng-Teng Huang,Jaung-Geng Lin
Yu-Hsuan Chen
Neuropathic pain is a prevalent, intolerable disease that poses significant clinical challenges due to the limited efficacy and adverse effects of conventional pharmacotherapy. Acupuncture is widely recognized for its efficacy in neuropathi...
Emodin Inhibitsg Hepatocellular Carcinoma Invasion and Migration by Regulating the HDAC4/NF-[Formula: see text]B (p65)/CXCL12 Signaling Axis and Suppressing M2 Macrophage Polarization [0.03%]
大黄素通过调节HDAC4/NF-κB(p65)/CXCL12信号轴和抑制M2型巨噬细胞极化来抑制肝癌侵袭和转移
Yi-Qiong Zhang,Yong-Jie Xu,Hai-Zhi Li et al.
Yi-Qiong Zhang et al.
This study aims to investigate how emodin, an active component of Polygonum multiflorum, regulates macrophage polarization through the HDAC4/NF-[Formula: see text]B/CXCL12 pathway and impacts the progression of hepatocellular carcinoma (HCC...