Quercetin-Induced Ferroptosis Attenuates Pancreatic Ductal Adenocarcinoma via Facilitating NCOA4-Dependent Ferritinophagy [0.03%]
染料木素通过促进NCOA4依赖性铁死亡诱导溶酶体铁转运从而抑制胰腺导管腺癌
Chang Li,Liya Zhou,Xunzhe Yin
Chang Li
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of malignancies. Quercetin (QCT), a natural flavonoid, exhibits broad pharmacological activities and minimal toxicity, which makes it a promising candidate for cancer therapy....
Tumor Immune Regulation by Natural Products: Mechanistic Insights and Therapeutic Potential [0.03%]
天然产物对肿瘤免疫的调节作用：机制见解与治疗潜力
Qianqian Wang,Zihan Zhang,Xiaotong Sun et al.
Qianqian Wang et al.
Frequently evolving into a highly immunosuppressive niche that facilitates tumor growth and metastasis, the tumor microenvironment (TME) serves as the primary site for interactions between tumor cells and the host immune system. Reversing t...
Traditional Chinese Medicine in the Treatment of Ulcerative Colitis: From Pharmacokinetics to Personalized Therapy [0.03%]
溃疡性结肠炎中医药治疗从药代动力学角度探析至个体化治疗展望
Xingju Peng,Suman Zheng,Gege Tian et al.
Xingju Peng et al.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease driven by immune dysregulation, intestinal microbiota imbalance, and disruption of the mucosal barrier. Current clinical management is challenged by high relapse rates and sign...
Luteolin Triggers Pyroptosis in Pancreatic Ductal Adenocarcinoma by Inhibiting Mitochondrial Fission through the RAS/ERK/DRP1 Pathway [0.03%]
黄酮类化合物核橘素通过RAS/ERK/DRP1信号通路抑制线粒体分裂触发胰腺导管腺癌细胞焦亡
Wai-Mei Si,Xin Li,Yuan Zhang et al.
Wai-Mei Si et al.
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies and lacks effective therapies. Luteolin, a dietary flavonoid with broad antitumor activity, has shown anti-PDAC potential, yet whether it acts through RAS/ERK/DRP...
Tanshinone IIA Ameliorates Heart Failure by Inhibiting Ferroptosis via the Sirt1/p53/GPX4 Signaling Pathway [0.03%]
丹参酮ⅡA通过Sirt1/p53/GPX4信号通路抑制铁死亡改善心力衰竭
Guo-Fu Zhong,Zhi-Wen Jiang,Xin Huang et al.
Guo-Fu Zhong et al.
Heart failure (HF) is a high-mortality condition driven by cardiomyocyte death, and ferroptosis is a critical contributor to myocardial injury in this regard. Tanshinone IIA (Tan-IIA), a bioactive component from Salvia miltiorrhiza, has bee...
Aqsa Bibi,Li Zhou,Min You et al.
Aqsa Bibi et al.
Marked by high blood glucose and systemic metabolic dysfunction, type 2 diabetes mellitus (T2DM) is a significant health issue with a rapidly increasing worldwide prevalence. Recent studies have highlighted the gut microbiota as a key deter...
Mitochondria-Associated Ferroptosis and Diabetic Osteoporosis: Exploration of Traditional Chinese Medicine Treatment and Mechanisms of Action [0.03%]
线粒体相关铁死亡与糖尿病性骨质疏松症：中医药治疗及作用机制探讨
Guoyu Pang,Rui Bai,Mi Chen et al.
Guoyu Pang et al.
Diabetic osteoporosis (DOP) is a serious skeletal complication of diabetes mellitus. Its pathogenesis is complex, and its clinical prevention and treatment face significant challenges. In recent years, ferroptosis - particularly mitochondri...
Targeting Ferroptosis in Cardiovascular Diseases: The Emerging Role of Traditional Chinese Medicine [0.03%]
靶向心血管疾病铁死亡的中医药作用机制研究
Yanbin Chang,Yan Li,Ying Huang et al.
Yanbin Chang et al.
Ferroptosis is a distinct form of regulated cell death (RCD) characterized primarily by iron dysregulation and lipid peroxidation. Emerging evidence indicates ferroptosis critically contributes to the initiation and progression of multiple ...
Ting Cheng,Hu Xi,Wenjie Hao et al.
Ting Cheng et al.
Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, plays a critical role in various diseases. Berberine, a bioactive compound from plants such as Coptis chinensis, tree turmeric, and barberry, ex...
Modulation of Ferroptosis: A Novel Mechanism of Traditional Chinese Medicine in Managing Chronic Atrophic Gastritis [0.03%]
中药调控铁死亡在慢性萎缩性胃炎治疗中的新机制研究
Hengwang Gu,Yanzhu Chen,Yuyu Lin et al.
Hengwang Gu et al.
Chronic atrophic gastritis (CAG) is a major precancerous lesion of gastric cancer, characterized by a high incidence rate, a protracted clinical course, and a well-documented risk of malignant transformation. Current Western medical treatme...