Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text] [0.03%]
番红花素预处理通过丝氨酸-1-磷酸和缺氧诱导因子-1调节保护神经元免受缺血伤害
Qichun Zhang,Huimin Bian,Liwei Guo et al.
Qichun Zhang et al.
Berberine exerts neuroprotective and modulates hypoxia inducible factor-1-alpha (HIF-1[Formula: see text]. Based on the role of HIF-1[Formula: see text] in hypoxia preconditioning and association between HIF-1[Formula: see text] and sphingo...
Emodin Decreases Hepatic Hypoxia-Inducible Factor-1[Formula: see text] by Inhibiting its Biosynthesis [0.03%]
大黄素通过抑制其生物合成降低肝细胞缺氧诱导因子-1[Formula: see text]
Feifei Ma,Lijuan Hu,Ming Yu et al.
Feifei Ma et al.
Hypoxia-inducible factor-1 (HIF-1) is an [Formula: see text] dimeric transcription factor. Because HIF-1[Formula: see text] is instable with oxygen, HIF-1 is scarce in normal mammalian cells. However, HIF-1[Formula: see text] is expressed i...
Immune Enhancing Activity of β-(1,3)-Glucan Isolated from Genus Agrobacterium in Bone-Marrow Derived Macrophages and Mice Splenocytes [0.03%]
来自基因Agrobacterium的β-(1,3) -glucan增强免疫活性在骨髓衍生的巨噬细胞和小鼠脾细胞中
Eui-Baek Byun,Beom-Su Jang,Eui-Hong Byun et al.
Eui-Baek Byun et al.
An effective method for activating macrophages and deriving a Th1 immune response could be used to improve the defenses of hosts. In this study, we investigated the immunomodulation effect and the related signaling mechanism of [Formula: se...
Pinellia ternata Attenuates Mucus Secretion and Airway Inflammation after Inhaled Corticosteroid Withdrawal in COPD Rats [0.03%]
半夏能改善慢性阻塞性肺疾病模型小鼠断用吸入性糖皮质激素后的痰液分泌和气道炎症反应
Wei Du,Jinyu Su,Dan Ye et al.
Wei Du et al.
Inhaled corticosteroids (ICS) are widely used to manage chronic obstructive pulmonary disease (COPD). However, withdrawal of ICS generally causes various adverse effects, warranting careful management of the ICS withdrawal. Pinellia ternata...
Screening of Intestinal Bacterial Metabolites of Platycodin D Using Ultra-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry [0.03%]
运用超高效液相色谱-四极杆飞行时间质谱筛选北沙参platycodin D的肠道菌代谢物
Wei Zhang,Shi-Hui Qian,Da-Wei Qian et al.
Wei Zhang et al.
Platycodin D (PD), a bioactive triterpenoid saponin isolated from Platycodi Radix (PR), possesses a vast range of biological activities. Although the pharmacological activities and pharmacokinetics of PD have been well demonstrated, informa...
Geniposide Inhibits Alpha-Naphthylisothiocyanate-Induced Intrahepatic Cholestasis: The Downregulation of STAT3 and NF[Formula: see text]B Signaling Plays an Important Role [0.03%]
宫炎草苷通过下调STAT3和NF-[Formula: see text]B信号途径抑制α-萘硫氰酸酯致肝内胆汁淤积作用研究
Zhen Tan,Aiming Liu,Min Luo et al.
Zhen Tan et al.
Traditional medicinal formulation of Yin-zhi-huang (YZH) is widely used in the clinic for the treatment of jaundice and chronic liver diseases in East Asian countries. However, the pharmacologically active components of YZH and the underlyi...
Modulation of the Tumor Metastatic Microenvironment and Multiple Signal Pathways by Prunella vulgaris in Human Hepatocellular Carcinoma [0.03%]
石斛属下的一种植物——贯叶金丝桃素通过调节肿瘤转移微环境及多条信号通路抑制人类肝癌细胞侵袭和转移的研究
Yu-Chieh Su,I-Hsin Lin,Yu-Miao Siao et al.
Yu-Chieh Su et al.
Prunella vulgaris (PV) is a traditional Chinese medicine that has been used clinically for centuries in Asian countries to treat herpetic keratitis. In previous studies, PV was shown to suppress TPA-induced activation of MMP-9 and inhibit c...
Effects of Panax notoginseng on the Metastasis of Human Colorectal Cancer Cells [0.03%]
云南三七对人结直肠癌细胞转移的影响
Shu-Ling Hsieh,Shuchen Hsieh,Yu-Hao Kuo et al.
Shu-Ling Hsieh et al.
The goal of this study was to investigate the effect of the Panax notoginseng ethanol extract (PNEE) on the regulation of human colorectal cancer (CRC) metastasis. The migratory, invasive, and adhesive abilities and the expression of metast...
Cytotoxicity of Salvia miltiorrhiza Against Multidrug-Resistant Cancer Cells [0.03%]
丹参对多药耐药癌细胞的细胞毒性作用
Ching-Fen Wu,Stefan Bohnert,Eckhard Thines et al.
Ching-Fen Wu et al.
Salvia miltiorrhiza Bunge (Lamiaceae) is a well-known Chinese herb that possesses numerous therapeutic activities, including anticancer effects. In this study, the cytotoxicity and the biological mechanisms of S. miltiorrhiza (SM) root extr...
Traditional Chinese Medications for Knee Osteoarthritis Pain: A Meta-Analysis of Randomized Controlled Trials [0.03%]
膝骨关节炎止痛的中药疗法：随机对照试验的meta分析研究
Bo Chen,Hongsheng Zhan,Jolanta Marszalek et al.
Bo Chen et al.
Traditional Chinese medication (TCM) has analgesic and anti-inflammatory effects in patients with knee osteoarthritis (OA). We conducted the first systematic review of the best quantitative and qualitative evidence currently available in or...