Cordycepin: A Promising Anticancer Compound from Traditional Chinese Medicine [0.03%]
虫草素：一种有前景的抗癌中药成分
Yibang Li,Youyan Han,Nanmiao Wang et al.
Yibang Li et al.
As cancer continues to pose a significant threat to human health, the search for effective therapeutic agents has become a critical focus in medical research. Cordyceps is a fungus used in traditional Chinese medicine (TCM) valued for its p...
Identification of Flavonoid Compounds in Treating Alzheimer's Disease Based on Network Medicine Framework Strategy [0.03%]
基于网络药理学框架策略的 flavonoid 化合物治疗阿尔茨海默病的识别
Min-Rui Ding,Cai-Yun Xia,Yan-Jie Qu et al.
Min-Rui Ding et al.
Alzheimer's disease (AD) currently lacks effective therapeutics, but blood-brain-barrier-penetrating flavonoids show promising therapeutic potential. To address this critical need, we employed a novel network medicine framework to systemati...
Advancing Traditional Chinese Medicine Research through Network Pharmacology: Strategies for Target Identification, Mechanism Elucidation and Innovative Therapeutic Applications [0.03%]
网络药理学促进中医药创新研究：靶点发现、机制阐释和新药创制策略探讨
Xiaobing Li,Xiaodong Li,Li Wang et al.
Xiaobing Li et al.
Traditional Chinese medicine (TCM) is characterized by its multi-component, multi-target, and multi-pathway properties, which make it an ideal candidate for network pharmacology applications. This approach provides a comprehensive framework...
Targeting Myeloperoxidase in Disease Pathogenesis: Emerging Roles of Natural Products in Therapeutic Modulation [0.03%]
针对髓过氧化物酶的疾病发病机制研究：天然产物在治疗调节中的新角色
Qing Nian,Ziqiang Liu,Jinhao Zeng et al.
Qing Nian et al.
Myeloperoxidase (MPO) is a heme-containing enzyme that regulates inflammation and oxidative stress under normal physiological conditions, but when dysregulated, it contributes to the development and progression of cardiovascular, immune-rel...
Therapeutic Prospects of Ursolic Acid in Colorectal Cancer: Modulation of the Wnt/[Formula: see text]-Catenin Signaling Pathway and Gut Microbiota Composition [0.03%]
乌索林酸在结直肠癌治疗中的前景：调控Wnt/β-catenin信号通路和肠道微生物群组成的影响
Hui Zhao,Miaoxin Jin,Jingyi Qiao et al.
Hui Zhao et al.
This investigation is designed to delineate the antineoplastic properties of ursolic acid against colorectal cancer and to elucidate underlying molecular mechanisms, including its influence on gut microbiota homeostasis as assessed by alpha...
Green Tea and Epigallocatechin Gallate (EGCG) for Cancer Prevention: A Systematic Review and Meta-Analysis [0.03%]
绿茶和儿茶素埃ɡ加allocatECHIN(EGCG)抗癌预防：系统回顾及元分析
Yang Zhang,Qiong Xu,Jiepin Hu et al.
Yang Zhang et al.
Previous studies have reported inconsistent effects of green tea and its extract, epigallocatechin gallate (EGCG), on cancer prevention. We aimed to uncover the protective effects of green tea or EGCG against cancer, and to assess the dose-...
Tanshinone IIA Inhibits NADPH Oxidase 4 Expression by Regulating Sestrin2-Mediated AMPK/mTOR Signaling Pathway to Alleviate Myofibroblast Activation in Pulmonary Fibrosis [0.03%]
丹参酮ⅡA通过调节Sestrin2介导的AMPK/mTOR信号通路抑制NADPH氧化酶4表达缓解肺纤维化肌成纤维细胞活化作用
Congying Guo,Sheng Ai,Mingyu Wu et al.
Congying Guo et al.
Oxidative stress serves as a driving force for myofibroblast activation in pulmonary fibrosis (PF). As a main enzymatic source of reactive oxygen species (ROS), NADPH oxidase 4 (Nox4) plays a critical role in modulating myofibroblast activa...
Gastrodia elata Polysaccharide Ameliorates Parkinson's Disease by Enhancing Dopamine Levels, Inhibiting NLRP3 Inflammasome Activation, and Promoting Mitochondrial Autophagy [0.03%]
天麻多糖通过提升多巴胺水平、抑制NLRP3炎性小体活化和促进线粒体自噬改善帕金森病功效研究
Shidai Li,Ming Li,Yangping Li et al.
Shidai Li et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by dopaminergic (DA) neuron loss and neuroinflammation. Current therapies fail to halt disease progression, which underscores the need for new treatments. This stud...
Quercetin Alleviates Folic Acid-Induced Renal Fibrosis by Inhibiting Tubular Epithelial Cell Ferroptosis via EGFR/ACSL4 Pathway [0.03%]
檞皮素通过抑制EGFR/ACSL4途径介导的肾小管上皮细胞铁死亡来缓解叶酸诱导的肾纤维化
Xian-Li Gao,Ting Chen,Shao-Ling Lin et al.
Xian-Li Gao et al.
Ferroptosis has emerged as a critical contributor to the pathogenesis of chronic kidney disease (CKD). Quercetin, a promising therapeutic agent and flavonoid with potential antiferroptotic properties, has demonstrated renoprotective effects...
Cistanche deserticola Polysaccharides Mitigate Alzheimer's Disease Progression by Dynamic Regulation of Gut Microbiota Composition and Metabolites [0.03%]
肉苁蓉多糖通过动态调节肠道菌群组成及代谢物改善阿尔茨海默病进展作用机制研究
Yuan Gao,Chun-Sheng Zhang,Yan Liang et al.
Yuan Gao et al.
Cistanche deserticola polysaccharides (CDPS) exhibit a range of pharmacological activities, most notably in immune modulation, anti-oxidation, and gut microbiota regulation. Emerging evidence suggests that restoring gut microbial and metabo...