Mast Cell-related Prognosis Signature Characterizes Immune Landscape and Predicts Prognosis of Ovarian Cancer [0.03%]
与肥大细胞相关的预后标志表征卵巢癌免疫图谱并预测其预后
Qinghua Li,Tianyun Guan,Jianxiong Mao et al.
Qinghua Li et al.
Background/aim: Ovarian cancer (OVC) is a common, aggressive, and heterogeneous malignancy, with a widely variable prognosis. With the advances of modern immunology, mast cells (MCs) have been shown to play a significant ...
NUAK2 Inhibitors, KHKI-01128 and KHKI-01215, Exhibit Potent Anticancer Activity Against SW480 Colorectal Cancer Cells [0.03%]
NUAK2抑制剂KHKI-01128和KHKI-01215对SW480结肠癌细胞具有较强的抗癌活性
Seung Hyeong Lee,Su Ah Kim,Su Jin Park et al.
Seung Hyeong Lee et al.
Background/aim: NUAK family kinase 2 (NUAK2) is a promising target for cancer therapeutics due to its reported role in protein phosphorylation, a critical process in cancer cell survival, proliferation, invasion, and sene...
Contribution of Matrix Metalloproteinase-7 Genotypes to Endometriosis Risk in Taiwan [0.03%]
基质金属蛋白酶7基因型对中国台湾地区子宫内膜异位症发病风险的影响研究
Hung-Ju Chien,Yun-Chi Wang,Wen-Shin Chang et al.
Hung-Ju Chien et al.
Background/aim: The activity and expression of matrix metalloproteinase-7 (MMP7) have been found to be upregulated in the late stages of endometriosis. However, the contribution of MMP7 genotype to endometriosis has seldo...
Clinical Diagnostic Value of circ-ARHGER28 for Breast Cancer and its Effect on MCF 7 Cell Proliferation and Apoptosis [0.03%]
circ-ARHGER28在乳腺癌中的临床诊断价值及其对MCF 7细胞增殖和凋亡的影响
Xiang Tao,L I Na,En-Xi Hu et al.
Xiang Tao et al.
Background/aim: Clinical diagnostic value of circ-ARHGER28 in breast cancer (BC), and the biological functions of circ-ARHGER28 on the proliferation and apoptosis of MCF-7 cells were investigated. ...
Advances in Spinal Neuromodulation for Chemotherapy-induced Peripheral Neuropathy [0.03%]
化疗诱导的外周神经病理性疼痛的脊髓电刺激疗法新进展
Puneet Gupta,Kunj Patel,Geet Paul
Puneet Gupta
Background/aim: Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a major source of chronic morbidity in patients with cancer. Current treatment options and efficacy are limited; thus, there is a need to i...
TLK1 Inhibition Enhances the Anticancer Effect of Deep UV Irradiation Through CHK1 Activation [0.03%]
TLK1抑制通过激活CHK1增强深紫外线照射的抗癌作用
Yoshio Koike,Toshio Kokuryo,Junpei Yamaguchi et al.
Yoshio Koike et al.
Background/aim: A deep ultraviolet (DUV) light-emitting diode (LED) is a device that can irradiate electromagnetic waves from 250 nm to 350 nm. Tousled-like kinase 1 (TLK1) encodes a nuclear serine/threonine kinase, which...
Modulation of the Prostate Cancer Resistance Factor Hsp27 by the Chemotherapeutic Drugs Abiraterone, Cabazitaxel, Docetaxel and Enzalutamide [0.03%]
新型前列腺癌化疗药物调控前列腺癌耐药因子Hsp27的表达及机制研究
Jennifer H S Küster,Holger H H Erb,Hannes Ahrend et al.
Jennifer H S Küster et al.
Background/aim: The cytoprotective heat shock protein 27 (HSP27) acts as a protein chaperone, antioxidant, and apoptosis regulator and is involved in cytoskeletal remodeling in prostate cancer. This study was designed to ...
Down-regulation of ABCB1 in Everolimus-resistant Renal Cell Carcinoma Cells [0.03%]
依维莫司耐药肾癌细胞中ABCB1的下调作用
Yuko Nakayama,Aya Ino,Kazuhiro Yamamoto et al.
Yuko Nakayama et al.
Background/aim: Everolimus-resistant Caki/EV and 786/EV cells have been established from human derived renal cell carcinoma cells, Caki-2 and 786-O, respectively. These cells exhibit resistance to everolimus and to other ...
Enhancement of Tumor Antigen-specific T-cell Responses by Immune Checkpoint Blockade in Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma [0.03%]
免疫检查点阻断增强人乳头瘤病毒相关头颈鳞癌中肿瘤抗原特异性T细胞的反应
Kazuaki Chikamatsu,Shota Ida,Kei Masuda et al.
Kazuaki Chikamatsu et al.
Background/aim: Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is clinically and immunologically distinct from HPV-negative HNSCC. Herein, we investigated the presence of tumor antigens ...
Higher YAP1 Levels Are Associated With Shorter Survival of Patients With Low Grade Astrocytoma [0.03%]
YAP1蛋白水平与低级别胶质瘤患者生存期的关系研究
Jill Dicke,Laura Hero,Saskia Kuhl et al.
Jill Dicke et al.
Background/aim: Glioblastoma multiforme (GBM) is one of the most lethal types of brain cancer with a median survival of only 12 months due to its aggressiveness and lack of effective treatment options. Astrocytomas and ol...