Repetitive Magnetic Stimulation Modulates the Gene Expression of Neurotrophins and their Receptors in Neuroblastoma Cells [0.03%]
重复经磁刺激调节神经母细胞瘤细胞神经营养因子及其受体的基因表达
Amanda Stieven,Dirson João Stein,Khetrüin Jordana Fiuza et al.
Amanda Stieven et al.
Background/aim: Repetitive magnetic stimulation (rMS) is used to treat neurological conditions. Understanding its modulatory effects requires investigating cellular processes and molecular pathways in vitro. This study ai...
SLFN11 Drives GM-CSF-mediated M1 Macrophage Polarization and Enhances Immunotherapy Response in Renal Cell Carcinoma [0.03%]
SLFN11驱动GM-CSF介导的M1型肿瘤相关巨噬细胞极化并增强肾细胞癌免疫治疗效应
Yohei Okuda,Junko Murai,Tsuyoshi Takashima et al.
Yohei Okuda et al.
Background/aim: Advanced renal cell carcinoma (RCC) is commonly treated with immune checkpoint inhibitor (ICI)-based therapies. However, patient responses vary, and predictive biomarkers remain limited. Here, we demonstra...
Immunohistochemical Expression and Clinicopathological Assessment of PD-1, PD-L1, NY-ESO-1, and MAGE-A4 Expression in Desmoid Tumor [0.03%]
PD-1，PD-L1，NY-ESO-1和MAGE-A4在侵袭性纤维瘤病中的表达及临床病理学评估
Kazuhiko Hashimoto,Shunji Nishimura,Hiroki Tan et al.
Kazuhiko Hashimoto et al.
Background/aim: The action of immune molecular mechanisms in the intratumor microenvironment in desmoid tumors (DTs) remains unclear. The purpose of this research was to clarify the expression patterns of PD-1/PD-L1 immun...
Exploring the Contribution of Interleukin-17 Genetic Polymorphisms to Pterygium Risk [0.03%]
探索白细胞介素17基因多态性对翼状胬肉发病风险的贡献
Hung-Chih Chen,Ning-Yi Hsia,Pei-Shin Hu et al.
Hung-Chih Chen et al.
Background/aim: Pterygium is a chronic, fibrovascular ocular surface disorder with tumor-like biological behavior. Although inflammatory mediators such as interleukin-17 (IL17) are increasingly implicated in its pathogene...
Evaluation of Radiotherapy Dose in Secondary Breast Angiosarcoma: Implications for Pathogenesis [0.03%]
二次乳腺血管肉瘤的放射治疗剂量评估：对发病机制的意义
Samuli Salminen,Laura Tuomikoski,Maija Tarkkanen et al.
Samuli Salminen et al.
Background/aim: Survivors of early-stage breast cancer (BC) are at an increased risk of secondary breast angiosarcoma (AS), a rare cancer predominantly involving the superficial breast. The role of radiotherapy (RT) in th...
Activity of Ponatinib and Vitamin K2 Against Myelodysplastic Syndrome and Acute Myeloid Leukemia Cells [0.03%]
帕纳替尼和维生素K2对骨髓增生异常综合征及急性髓系白血病细胞的作用
Seiichi Okabe,Seiichiro Yoshizawa,Kai Osone et al.
Seiichi Okabe et al.
Background/aim: Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy often characterized by poor response to conventional therapies and frequent relapse. Ponatinib, a third-generation tyrosine kinase inh...
Efficacy of Second-line Lenvatinib for Hepatocellular Carcinoma After Early Progression on Atezolizumab-Bevacizumab [0.03%]
阿特珠单抗贝伐珠单抗治疗早期进展的肝细胞癌患者再次使用仑伐替尼的疗效研究
Hisanori Muto,Teiji Kuzuya,Yoshihiko Tachi et al.
Hisanori Muto et al.
Background/aim: Atezolizumab plus bevacizumab (Ate+Bev) is widely used as first-line therapy for unresectable hepatocellular carcinoma (HCC). However, a subset of patients experience early disease progression, often detec...
Expression of YME1 Like 1 ATPase Increases With the Stage of Adrenocortical Carcinoma Tissue and Is Associated With Poor Patient Prognosis [0.03%]
腺皮质癌组织yme1样1atp酶的表达随着分期增加且与患者预后不良相关
Shin-Nosuke Yamashita,Yoshiatsu Tanaka,Shajedul Islam et al.
Shin-Nosuke Yamashita et al.
Background/aim: Adrenocortical carcinoma (ACC) is an endocrine tumor arising in the adrenal cortex. Although its incidence is extremely low, it is highly malignant, rapidly proliferating, and infiltrating surrounding orga...
Expression of Vascular Endothelial Growth Factor A in Gallbladder Cancer Cells: A Clinicopathological Study [0.03%]
血管内皮生长因子A在胆囊癌细胞中的表达：临床病理学研究
Takafumi Okayama,Takashi Taniguchi,Takahiro Tomosugi et al.
Takafumi Okayama et al.
Background/aim: Vascular endothelial growth factor (VEGF) is a key mediator of tumor angiogenesis. However, the clinicopathological and prognostic significance of VEGF expression gallbladder cancer (GBC) remains incomplet...