Sulfasalazine an Inhibitor of System xC - (Cystine/glutamate Antiporter), Combined With Recombinant Methioninase, Inhibits Both Cancer and Normal Cells, Suggesting Lack of Cancer Selectivity of Cysteine Restriction
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Background/aim: Sulfasalazine (SSZ), an inhibitor of xCT/system xC -, blocks cystine uptake and depletes intracellular glutathione, leading to ferroptotic cell death. Recombinant methioninase (rMETase) targets methionine addictio... ...
