Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review) [0.03%]
尿素循环失调和鸟氨酸-瓜氨酸-精氨酸途径在非酒精性脂肪肝病发生发展中的作用（综述）
Boying Zhu,Chaoyang Wang,Peng Liu et al.
Boying Zhu et al.
Non‑alcoholic fatty liver disease (NAFLD) and its advanced form, non‑alcoholic steatohepatitis (NASH), are now leading causes of chronic liver disease worldwide. Recent evidence highlights the central role of urea cycle and arginine metab...
Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review) [0.03%]
植物来源的天然产物通过调节FoxO缓解地塞米松诱导的骨骼肌萎缩（综述）
Wei Dai,Jiabin Wu,Xiaotong Ma et al.
Wei Dai et al.
Muscle atrophy (MA) is a major global health issue, and systematic strategies for its prevention and treatment are lacking. Diverse factors contribute to MA, amongst which the exogenous over‑supplementation and endogenous pathological elev...
Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review) [0.03%]
心肾综合征3型和4型实验动物模型的研究进展及临床意义（综述）
Stefanny M Figueroa,Siyi Huang,Javier Reyes-Osorio et al.
Stefanny M Figueroa et al.
Cardiorenal syndrome (CRS) encompasses the bidirectional and complex interaction between cardiac and renal dysfunction. The present review focuses on CRS types 3 and 4, highlighting the negative effects of acute kidney injury and chronic ki...
[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert [0.03%]
miR-215通过调控LEFTY2促进子宫内膜癌上皮间质转化及增殖（已撤稿）
Xiaoxu Gao,Yan Cai,Ruifang An
Xiaoxu Gao
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that western blot data shown in Fig. 1C on p. 1232 were strikingly similar to data in a paper that had previously been published in the jo...
Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis [0.03%]
乳酸通过软骨H3K18去乙酰化调节骨关节炎的破骨细胞生成
Zhibo Fan,Qiyue Fu,Tao Sun et al.
Zhibo Fan et al.
Osteoarthritis (OA), characterized by articular cartilage degeneration and subchondral bone remodeling, is a notable cause of disability globally. The present study aimed to explore the role and mechanism of histone H3 lysine 18 lactylation...
[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2 cardiac myocytes [0.03%]
[表达关切]HSP90在H2S细胞保护作用中的新见解及其对化学缺氧诱导的H9c2心肌细胞损伤的影响
Zhanli Yang,Chuntao Yang,Liangcan Xiao et al.
Zhanli Yang et al.
Following the publication of this paper, and an Expression of Concern statement that was published to draw attention to the fact that the Editorial Office are in the process of consulting the authors regarding the fact that the photos shown...
Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis [0.03%]
微生物衍生的吲哚-3-丙酸通过抑制PPARγ重新编程骨髓干细胞命运以缓解骨质疏松症
Jinwu Bai,Ruideng Wang,Jixing Fan et al.
Jinwu Bai et al.
Osteoporosis (OP) is increasingly recognised as a disorder driven by impaired lineage allocation of bone marrow stromal cells (BMSCs), characterised by a shift from osteogenesis toward adipogenesis under conditions such as oestrogen deficie...
Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review) [0.03%]
心血管治疗中的功能水凝胶：设计、应用及临床挑战（综述）
Zheming Yang,Jiayin Li,Lingxiao Zhao et al.
Zheming Yang et al.
Cardiovascular disease (CVD) is the leading cause of mortality worldwide, and conventional treatments (such as pharmacotherapy, stents and bypass surgery) have limited capacity to repair damaged cardiovascular tissue. Hydrogels, as biocompa...
Qin Yu,Jiarui Hu,Shuangshuang Yuan et al.
Qin Yu et al.
Angiogenesis is defined as the formation of new blood vessels originating from pre‑existing vasculature and serves a critical role in physiological developmental processes. In addition, angiogenesis serves important roles in various pathol...
Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review) [0.03%]
肝细胞癌中靶向乳酸化的分子机制及治疗策略(综述)
Lianting Chen,Feiqiong Gao,Qianru Mei et al.
Lianting Chen et al.
Hepatocellular carcinoma (HCC) is a malignant tumor characterized by profound metabolic reprogramming and a pronounced Warburg effect, resulting in excessive lactate accumulation in the tumor microenvironment (TME). Traditionally regarded a...