Research progress on TMEM proteins in cancer progression and chemoresistance (Review) [0.03%]
肿瘤发生发展及耐药中TMEM蛋白的研究进展(综述)
Ji Shi,Duo Zheng,Bing Yao et al.
Ji Shi et al.
In cancer research, the transmembrane (TMEM) family of proteins has attracted considerable attention due to its role in tumor progression and chemoresistance. These membrane proteins are integral to cellular processes, including signal tran...
Suppression of tumor growth by GMI, an edible fungal immunomodulatory protein, is associated with targeting GSK3β‑mediated proteasomal degradation of PD‑L1 [0.03%]
一种可食用的药用真菌免疫调节蛋白GMI通过靶向GSK3β介导的PD-L1泛素蛋白酶体降解抑制肿瘤生长
Wei-Jyun Hua,Li-Chen Huang,Zhi-Hu Lin et al.
Wei-Jyun Hua et al.
Cancer cells evade T cell responses by exploiting programmed death‑ligand 1 (PD‑L1) in the tumor microenvironment, and oncogenic epidermal growth factor receptor (EGFR) signaling stabilizes PD‑L1 expression. Ganoderma microsporum immunom...
Xiaowen Wu,Ruiquan Wang,Xinzhe Chen et al.
Xiaowen Wu et al.
Myocardial fibrosis has emerged as a maladaptive remodeling process characterized by dysregulated extracellular matrix (ECM) deposition following cardiac injury. Recent studies have unveiled a complex RNA epitranscriptomic network that is c...
Mitochondrial dysfunction in perimenopausal mood disorders: From hormonal shifts to neuroenergetic failure (Review) [0.03%]
围绝经期情绪障碍中的线粒体功能紊乱：从激素变化到神经能量代谢衰竭（综述）
Yang Yu,Han Yapeng,Zelin Liu et al.
Yang Yu et al.
Perimenopause represents a key transition from a reproductive to non‑reproductive state in women, characterized by physiological and psychological changes. Mood disturbances during this period, such as depression, anxiety and cognitive dec...
CENPU promotes tumorigenesis and stem cell properties in triple‑negative breast cancer by suppressing lysosomal furin degradation [0.03%]
CENPU通过抑制溶酶体furin降解促进三阴性乳腺癌的肿瘤发生和干细胞特性
Shujuan Sun,Zhenyu Hou,Ling Qiang et al.
Shujuan Sun et al.
Centromere protein U (CENPU), a critical component of the kinetochore complex, structurally integrates with spindle microtubules to mediate chromosome segregation during mitosis. However, the association between CENPU expression levels and ...
Apelin‑13 in the paraventricular nucleus (PVN) attenuates myocardial ischemia through V1a receptors in PVN/nucleus tractus solitarii (NTS) and GARγ2 in NTS [0.03%]
下丘脑室旁核（PVN）中Apelin-13通过PVN/迷走神经背侧核(VLM)/GARγ2信号通路缓解心肌缺血作用及机制研究
Wen Yan,Dan Wang,Xinmin Zhang et al.
Wen Yan et al.
The apelin system plays a significant role in central blood pressure regulation, but its role in the neural control of myocardial protection remains poorly understood. The present study evaluated the effects of apelin‑13 in the paraventric...
Short‑chain fatty acids regulate hepatocellular carcinoma progression: A metabolic perspective on tumor immunity (Review) [0.03%]
短链脂肪酸通过代谢调控肝癌免疫进程（综述）
Dan Pan,Yiwen Bao,Xiaoping Lu et al.
Dan Pan et al.
Hepatocellular carcinoma (HCC) is among the most common and lethal cancers worldwide and is characterized by complex metabolic and immunological processes throughout its progression. Emerging research has underscored the critical involvemen...
The gut‑skin axis: Emerging insights in understanding and treating skin diseases through gut microbiome modulation (Review) [0.03%]
肠-皮肤轴系：通过调节肠道菌群来理解并治疗皮肤病的新认识(综述)
Yuantong Zhao,Chenchen Yu,Jingyu Zhang et al.
Yuantong Zhao et al.
Emerging evidence indicates a significant association between the composition and functionality of the gut microbiome and various skin disorders, including psoriasis, atopic dermatitis, acne and several dermatological conditions. The gut‑s...
Calycosin attenuates mitochondrial damage and pyroptosis in heart failure via the Nrf2/ROS/TXNIP pathway [0.03%]
甘草素通过Nrf2/ROS/TXNIP信号通路调控心力衰竭中心肌细胞线粒体损伤和焦亡作用研究
Hua-Jing Yuan,Quan-Cheng Han,Yi-Ding Yu et al.
Hua-Jing Yuan et al.
Heart failure (HF) is a key public health concern worldwide due to its high morbidity and mortality rates. Calycosin (CA) is a flavonoid natural product that effectively treats HF with cardioprotective effects; however, its mechanism of act...
Aging of the human eye lens: Epigenetic landscape and therapeutic targets in age‑related cataracts (Review) [0.03%]
人眼晶状体老化：年龄相关性白内障的表观遗传景观和治疗靶点（综述）
Wenxin Yang,Yingying Zheng,Silong Chen et al.
Wenxin Yang et al.
Age‑related cataracts (ARCs) are the predominant cause of blindness globally and are characterized by progressive opacification of the ocular lens. Although oxidative stress, ultraviolet radiation and metabolic dysfunction are well‑docume...