Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review) [0.03%]
神经素-1在骨折修复过程中神经-血管-骨结合中的新兴作用(综述)
Keyue Zhang,Tong Li,Huan Liu et al.
Keyue Zhang et al.
Fracture healing is a sophisticated biological process orchestrated by the spatiotemporal coordination of neural, vascular and skeletal systems to sustain reparative homeostasis. However, this regulatory network is often disrupted in pathol...
TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review) [0.03%]
TRPV1介导的中枢敏化在偏头痛慢性化进程中的核心机制及新型靶向治疗策略（综述）
Mingxia Zhang,Yuting Pu,Yujie Zhang et al.
Mingxia Zhang et al.
Migraines are highly prevalent and disabling neurological disorders. Central sensitisation constitutes the core pathophysiological basis for its recurrent and chronic nature. Transient receptor potential vanilloid 1 (TRPV1), a key molecule ...
Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review) [0.03%]
血液系统恶性肿瘤中血栓形成中的中性粒细胞胞外诱捕网：潜在机制及治疗机会（综述）
Kebing Lv,Zijie Ma,Qiuni Chen et al.
Kebing Lv et al.
Patients with cancer, particularly those diagnosed with hematological malignancies, exhibit thrombus incidence rates that exceed those observed in the general population by a substantial margin, and this elevated risk is associated with wor...
Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review) [0.03%]
线粒体-内质网接触位点枢纽：分子整合、疾病发病机制及治疗机会（综述）
Yi Liu,Xianda Che,Wei Wei et al.
Yi Liu et al.
Mitochondria‑endoplasmic reticulum contact sites (MERCs) are dynamic, nanoscale membrane domains that serve as crucial signaling hubs for inter‑organellar communication. These specialized interfaces are maintained by a complex network com...
Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review) [0.03%]
从肠道到关节的代谢信使：向精准管理骨关节炎迈进（综述）
Ruipu Zhang,Liang Zhang,Yiqun Wang et al.
Ruipu Zhang et al.
Osteoarthritis has evolved from a mechanical concept to a metabolic whole‑organ disease driven by systemic inflammation. The 'gut‑joint axis' represents a 'biological highway' where intestinal dysbiosis permits the translocation of microb...
MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review) [0.03%]
MTA2：解码病理机制、临床意义及疾病谱系中的治疗前沿（综述）
Hao Xie,Ling Chen,Jing Gou et al.
Hao Xie et al.
Metastasis‑associated protein 2 (MTA2), a crucial member of the metastasis‑associated family of transcriptional regulators, serves as a core component of the Mi‑2/nucleosome remodeling and deacetylase complex. It contributes to diverse h...
Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway [0.03%]
重组肌连接素通过脂连蛋白受体1/AMPK途径缓解线粒体功能障碍来改善脓毒症诱导的心肌病
Peipei Li,Rui Chen,Hanmo Zhang et al.
Peipei Li et al.
Sepsis‑induced cardiomyopathy (SIC) is a common complication of sepsis and is associated with a high mortality rate; however, effective therapies remain lacking. Mitochondrial dysfunction is a key pathogenic mechanism. Myonectin, also know...
Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review) [0.03%]
运动介导的骨稳态中的肌细胞因子：分子信号转导机制及骨疾病的治疗意义(综述)
Bin Tian,Xuesong Chen,Jiang Zheng et al.
Bin Tian et al.
Skeletal muscle functions as an endocrine organ, secreting myokines that mediate interorgan communication with bone. Exercise‑induced myokines regulate bone homeostasis by orchestrating osteoblast differentiation, osteoclastogenesis, and o...
Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review) [0.03%]
骨骼肌源性外泌体在多器官退行性疾病中的作用：机制和治疗递送前景（综述）
Xianji Wei,Chengyan Guo,Wei Zhang et al.
Xianji Wei et al.
Multi‑organ degenerative diseases are age-associated or chronic disorders marked by progressive tissue deterioration, impaired repair and functional decline, with representative conditions including sarcopenia, osteoporosis, osteoarthritis...
Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury [0.03%]
氢可酮诱导脑缺血再灌注炎症损伤的分子机制研究
Jing Yao,Zeqing Huang,Songze Li et al.
Jing Yao et al.
The present study explored the protective mechanism of hydromorphone (HM) preconditioning in cerebral ischemia/reperfusion injury (CIRI). An animal model of CIRI was established by middle cerebral artery occlusion/reperfusion in male C57BL/...