circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching [0.03%]
circCACNA1D通过调节丙酮酸激酶M2二聚体-四聚体转换驱动肺纤维化
Yujie Wang,Xiaoting Li,Meirong Wang et al.
Yujie Wang et al.
Pulmonary fibrosis is a progressive and fatal interstitial lung disease characterized by aberrant fibroblast activation and excessive extracellular matrix deposition. Circular RNAs (circRNAs) have emerged as critical regulators of fibrotic ...
Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review) [0.03%]
特发性肺纤维化中靶向肺泡II型细胞功能障碍：分子机制和新兴治疗策略(综述)
Tianhao Xie,Kang Hu,Shu Pan et al.
Tianhao Xie et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal and progressive form of interstitial lung pathology. It is characterized by the relentless replacement of functional alveolar epithelium by aberrant fibroblasts and excessive extracellular matr...
GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review) [0.03%]
GRP78失调：肿瘤微环境与癌症患者脓毒症易感性之间联系的分子机制假说(综述)
Hang Ruan,Meipeng Zhu,Shi-Yan Liu et al.
Hang Ruan et al.
Patients with cancer are at a significantly higher risk of sepsis, which is associated with substantially increased morbidity and mortality. However, the intrinsic molecular mechanisms driving sepsis susceptibility in this high‑risk popula...
[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression [0.03%]
[撤回]β-catenin信号通过上调osterix的表达主要诱导人成骨前体细胞和骨髓基质细胞向成骨细胞分化的信号
Bo Liu,Song Wu,Lihua Han et al.
Bo Liu et al.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the western blot data featured in Figs. 1A and 5A were strikingly similar to data that had already been submitted to the j...
[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells [0.03%]
[表达关注]HNF-4α在WB-F344细胞肝分化中的作用及其机制研究
Yumeng Shi,Dehua Zhou,Bingyi Wang et al.
Yumeng Shi et al.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that, regarding the images showing periodic acid‑Schiff staining in Fig. 5 on p. 1025, the 'PLKO‑SH' panel in Fig. 5A contained an overl...
Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization [0.03%]
苯基丙氨酸通过NF-κB介导的树突状细胞活化和Th17极化加重银屑病样炎症
Yaohan Xu,Jing Pan,Jie Chen et al.
Yaohan Xu et al.
Metabolic dysregulation has been increasingly recognized as a key driver in the pathogenesis of psoriasis; however, the specific mechanistic contributions of amino acid perturbations remain poorly understood. The present study, through comp...
Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review) [0.03%]
内分泌-代谢失衡驱动骨关节炎：从整体节段病理生物学到精准治疗（综述）
Ruhui Yang,Haimin Zeng,Qi Xiao et al.
Ruhui Yang et al.
Osteoarthritis (OA) is a chronic degenerative joint disease closely associated with aging and metabolic dysfunction, characterized by cartilage degeneration, synovial inflammation, aberrant subchondral bone remodeling, pain and progressive ...
Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review) [0.03%]
黄芪苷IV对各种肝脏疾病的保护作用：从化学到草药（综述）
Jialu Shi,Xiaoyu Zhou,Jiabin Wu et al.
Jialu Shi et al.
Numerous liver diseases are characterized by late diagnosis, rapid progression and high incidence, seriously threatening public health. Though widely used, traditional treatments such as drug therapy, resection and transplantation have subs...
Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging [0.03%]
单细胞图谱揭示WT1介导的轴在人类卵巢衰老过程中驱动颗粒细胞衰老的作用
Yanfang Du,Congyu Zhou,Yanpeng Tian et al.
Yanfang Du et al.
Ovarian aging is a key cause of reproductive decline in women. Chronic inflammation and granulosa cell (GC) senescence are implicated in this process; however, the underlying cell‑type‑specific changes and regulatory mechanisms remain inc...
FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review) [0.03%]
风团关节炎中FGFR1信号通路在骨破坏中的机制及其治疗靶向(综述)
Changzhong Qian,Zhenyu Zhang,Xian Wu et al.
Changzhong Qian et al.
Rheumatoid arthritis (RA) is an inflammatory, systematic and articular autoimmune disease characterized by progressive cartilage degradation and bone erosion, leading to irreversible joint deformity. Fibroblast growth factor receptor 1 (FGF...