Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review) [0.03%]
肠-肝-肾轴系：理解慢性肾脏病和治疗的系统生物学框架(综述)
Jinyi Hou,Yaotan Li,Shijia Lin et al.
Jinyi Hou et al.
Chronic kidney disease (CKD) is traditionally studied through an organ‑centric paradigm, despite its frequent coexistence with intestinal dysbiosis and metabolic dysfunction‑associated steatotic liver disease, which confers a 38% increase...
[Expression of Concern] Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway [0.03%]
[表达关注]声刺激通过簇素信号通路促进耳蜗核神经干细胞的增殖及分化
Tao Xue,Li Wei,Ding-Jun Zha et al.
Tao Xue et al.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that various of the flow cytometry plots featured in Fig. 6A subsequently appeared in six papers written by different authors at different...
Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review) [0.03%]
脓毒症诱发急性肺损伤中铁死亡的机制及治疗策略（英文）
Wenyu Wu,Nuoran Li,Guoshu Deng et al.
Wenyu Wu et al.
Sepsis‑induced acute lung injury (S‑ALI) is a leading cause of respiratory failure and mortality in intensive care units, characterized by profound biological and clinical heterogeneity that explains the repeated failure of uniform anti‑...
Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review) [0.03%]
神经纤维蛋白与骨病：机制和治疗意义(综述)
Shuhong Zhang,Ge Yang
Shuhong Zhang
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder caused by pathogenic mutations in the NF1 gene, which encodes neurofibromin, a critical tumor suppressor and regulator of intracellular signaling. NF1 is a multisystem...
Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review) [0.03%]
宫颈神经内分泌肿瘤的治疗新进展及策略(综述)
Yanpeng Tian,Yu Zhang,Liling Wang et al.
Yanpeng Tian et al.
Neuroendocrine neoplasms (NENs) are a rare type of tumor originating from peptidergic neurons and neuroendocrine cells, which exhibit neuroendocrine differentiation and neuroendocrine marker expression. NENs can occur in any part of the bod...
Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review) [0.03%]
运动诱导的外泌体非编码RNA：骨重建中的分子信号转导及其在运动相关性骨损伤中的转化应用(综述)
Bin Tian,Xuesong Chen,Jiang Zheng et al.
Bin Tian et al.
Exercise has profound beneficial effects on bone health, yet the molecular mechanisms that mediate mechanical force transduction remain incompletely understood. Exosomal noncoding RNAs (ncRNAs) have emerged as critical intercellular messeng...
Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response [0.03%]
喜树碱通过调节压力和炎症反应抑制蜱传脑炎病毒感染
Wan-Da Tang,Lan-Juan Zhao
Wan-Da Tang
Cepharanthine is a potential candidate for developing antiviral agents against tick‑borne encephalitis virus (TBEV), which is a major cause of arboviral neuroinvasive diseases in humans. Cepharanthine is the only bisbenzylisoquinoline alka...
Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance [0.03%]
高温作用于克服人乳头状瘤病毒感染所致的主要组织相容性复合体I类下调和促进免疫监视的作用机制研究
Hanyu Wang,Hongxin Lang,Yaoxing Guo et al.
Hanyu Wang et al.
Immune‑regulatory dysfunction caused by human papillomavirus (HPV) infection can lead to severe condyloma acuminate (CA), and the treatment is challenged by obstinacy and recurrence. Hyperthermia treatment stimulates the immune response by...
[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells [0.03%]
[p73参与WWOX介导的白血病细胞凋亡]
Donghong Lin,Zhaolei Cui,Lingying Kong et al.
Donghong Lin et al.
Following the publication of the above article, a concerned reader drew the Editor's attention to the fact that, regarding the the western blot data shown in Fig. 4C on p. 853 for the Jurkat cell line, the p73 bands shown to portray the 72 ...
Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation [0.03%]
管状PFKFB3通过乳酸依赖性组蛋白H4K12乳酰化和HIPK2激活驱动糖尿病肾脏纤维化
Mingkun Xu,Linhang Fu,Yulong Zhang et al.
Mingkun Xu et al.
Aerobic glycolysis is increasingly recognized as a pathogenic driver in diabetic kidney disease (DKD). However, the epigenetic role of its end product, lactate, remains largely undefined. Spatial transcriptomics analysis revealed active gly...