Overexpression of microRNA‑486 affects the proliferation and chemosensitivity of mesothelioma cell lines by targeting PIM1 [0.03%]
微核糖核酸486影响PIM1调控的间皮瘤细胞增殖和化疗敏感性
Silvana Pinelli,Rossella Alinovi,Diana Poli et al.
Silvana Pinelli et al.
Dysregulated levels of microRNAs (miRNAs or miRs), involved in oncogenic pathways, have been proposed to contribute to the aggressiveness of malignant pleural mesothelioma (MPM). Previous studies have highlighted the downregulation of miRNA...
An update on genetic basis of generalized pustular psoriasis (Review) [0.03%]
关于泛发性脓疱型银屑病遗传基础的最新研究(综述)
Jiahong Zhou,Qing Luo,Yang Cheng et al.
Jiahong Zhou et al.
Generalized pustular psoriasis (GPP) is a rare and severe auto‑inflammatory skin disease that is characterized by recurrent, acute onset, and generalized pustular eruptions on erythematous, inflamed skin. GPP is traditionally classified as...
FGF21 attenuates hypoxia‑induced dysfunction and inflammation in HPAECs via the microRNA‑27b‑mediated PPARγ pathway [0.03%]
FGF21通过microRNA-27b介导的PPARγ通路减轻缺氧诱导的HPAEC功能障碍和炎症
Dan Yao,Qinlian He,Junwei Sun et al.
Dan Yao et al.
Pulmonary arterial hypertension (PAH), is a chronic and progressive disorder characterized by pulmonary vascular remodeling, including endothelial cell dysfunction and inflammation. MicroRNAs (miRNAs or miRs) play an important role in the d...
Role of 2‑series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non‑alcoholic fatty liver disease (Review) [0.03%]
2系列前列腺素在2型糖尿病和非酒精性脂肪肝病发病机制中的作用（综述）
Weixuan Wang,Xin Zhong,Jiao Guo
Weixuan Wang
Nowadays, metabolic syndromes are emerging as global epidemics, whose incidence are increasing annually. However, the efficacy of therapy does not increase proportionately with the increased morbidity. Type 2 diabetes mellitus (T2DM) and no...
Demetra Application: An integrated genotype analysis web server for clinical genomics in endometriosis [0.03%]
应用于子宫内膜异位症临床基因组学的集成型基因型分析网络服务器：德梅特拉应用软件
Louis Papageorgiou,Maria I Zervou,Dimitrios Vlachakis et al.
Louis Papageorgiou et al.
Demetra Application is a holistic integrated and scalable bioinformatics web‑based tool designed to assist medical experts and researchers in the process of diagnosing endometriosis. The application identifies the most prominent gene varia...
Attenuation of the upregulation of NF‑κB and AP‑1 DNA‑binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by SERCA2a overexpression [0.03%]
SERCA2a过表达减弱tübinger和缺氧/复氧诱导的新生大鼠心肌细胞中NF-κB和AP-1的DNA结合活性上调
Zhigang Qu,Xiaochun Lu,Yan Qu et al.
Zhigang Qu et al.
The present study aimed to investigate the effects of the overexpression of sarco/endoplasmic reticulum Ca2+‑ATPase (SERCA2a) on endoplasmic reticulum (ER) stress (ERS)‑associated inflammation in neonatal rat cardiomyocytes (NRCMs) induce...
Interleukin‑6 signalling as a valuable cornerstone for molecular medicine (Review) [0.03%]
白细胞介素-6信号转导作为分子医学的重要基石（综述）
Maria Trovato,Salvatore Sciacchitano,Alessio Facciolà et al.
Maria Trovato et al.
The biological abilities of interleukin‑6 (IL‑6) have been under investigation for nearly 40 years. IL‑6 works through an interaction with the complex peptide IL‑6 receptor (IL‑6R). IL‑6 is built with four α‑chain nanostructures, wh...
Exosomal microRNAs in colorectal cancer: Overcoming barriers of the metastatic cascade (Review) [0.03%]
结直肠癌外泌体微小RNA：克服转移级联的障碍（综述）
Joshua Miguel C Danac,Aileen Geobee G Uy,Reynaldo L Garcia
Joshua Miguel C Danac
The journey of cancer cells from a primary tumor to distant sites is a multi‑step process that involves cellular reprogramming, the breaking or breaching of physical barriers and the preparation of a pre‑metastatic niche for colonization....
Genotoxicity of chloroacetamide herbicides and their metabolites in vitro and in vivo [0.03%]
除草剂氯乙酰胺及其代谢产物的致基因毒作用：体内外研究
Xinyan Ma,Ying Zhang,Mingyang Guan et al.
Xinyan Ma et al.
The toxicity of chloroacetamide herbicide in embryo development remains unclear. Acetochlor (AC) is a chloroacetamide that metabolizes into 2‑ethyl‑6‑methyl-2-chloroacetanilide (CMEPA) and 6‑ethyl‑o‑toluidine (MEA). The present study ...
Upregulation of NFKBIZ affects bladder cancer progression via the PTEN/PI3K/Akt signaling pathway [0.03%]
NFKBIZ上调通过PTEN/PI3K/Akt信号通路影响膀胱癌进展
Tao Xu,Ting Rao,Wei-Ming Yu et al.
Tao Xu et al.
NF‑κB inhibitor ζ (NFKBIZ), a member of the IκB family that interacts with NF‑κB, has been reported to be an important regulator of inflammation, cell proliferation and survival. However, the role of NFKBIZ in bladder cancer (BC) rema...