IL‑17A+ γδT cell activation via the HMGB1‑TLR2/4‑NF‑κB signaling pathways in biliary atresia [0.03%]
HMGB1-TLR2/4-NF-κB信号通路介导的IL-17A+γδT细胞活化在胆道闭锁中的作用研究
Meng-Xin Zhang,Jing-Feng Tang,Mei Hong et al.
Meng-Xin Zhang et al.
IL‑17A+ γδT cells are involved in biliary atresia (BA) inflammatory injury; however, the mechanism underlying their activation remains unclear. The present study aimed to elucidate the mechanism by which γδT cells are activated to secr...
CircRAD18 promotes glioblastoma proliferation, migration and invasion via the miR‑1231/LUC7L2 axis [0.03%]
Circular RNA CircRAD18通过miR‑1231/LUC7L2轴促进胶质母细胞瘤的增殖、迁移和侵袭
Lumeng Song,Ping Xiong,Amu Jike et al.
Lumeng Song et al.
Glioblastoma (GBM) is an exceptionally aggressive and malignant central nervous system tumor with a poor prognosis. Studies suggest that circular RNAs (circRNAs) play a vital role in GBM progression. Exosomes, key mediators of intercellular...
Gut‑brain axis in anesthesia and critical illness: Molecular crosstalk and its impact on delirium and outcome (Review) [0.03%]
麻醉与危重状态下肠-脑轴的分子交流及其对术后谵妄和预后的影响（综述）
Xigang Ma,Yongsen Zhao
Xigang Ma
The gut‑brain axis (GBA) has emerged as a critical mediator of acute brain dysfunction, particularly postoperative delirium and sepsis‑associated encephalopathy, in surgical and critically ill patients. Anesthesia, surgical stress, and cr...
Primary cilia dysfunction: A critical driver of metabolic diseases (Review) [0.03%]
原纤毛功能障碍在代谢性疾病中的驱动作用（综述）
Xiaojing Wang,Yi Jin,Kejia Xie et al.
Xiaojing Wang et al.
Cilia dysfunction has been identified as a crucial but frequently overlooked factor in the pathogenesis of metabolic diseases, including obesity and diabetes. This review examines the multifaceted roles of primary cilia in various metabolic...
Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review) [0.03%]
自噬和代谢稳态：在肥胖相关代谢性疾病中的探索(综述)
Chenglin Lu,Xiangyu Qi,Yuting Tong et al.
Chenglin Lu et al.
Autophagy is an evolutionarily conserved catabolic process in which excessive nutrients, toxic protein aggregates, damaged organelles, and invading microorganisms in the cytoplasm can be isolated by the double‑membrane structure of autopha...
Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway [0.03%]
白桦脂酸通过AMPK-mTOR信号通路增强自噬来缓解骨质疏松症成骨细胞的炎症损伤
Yiwei Zhao,Zechao Qu,Lin Liu et al.
Yiwei Zhao et al.
Osteoporosis (OP) is a systemic disease characterized by a reduction in the number of trabecular bone structures and damage to the bone microstructure. It is commonly found in people who are aging or have estrogen deficiency. Oxidative stre...
[Retracted] Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress [0.03%]
[p38MAPK磷酸化调节抑制软骨细胞热应力或机械应力诱导的凋亡（已撤稿）
Ken Takebe,Takayuki Nishiyama,Shinya Hayashi et al.
Ken Takebe et al.
Following the publication of the above article, a concerned reader drew the Editor's attention to the fact that, regarding the caspase‑9 and cleaved caspase‑9 bands in Fig. 5D on p. 333, the bands shown for the '10% 0h' and the '10% 12h' ...
Ferroptosis in musculoskeletal disorders: Emerging mechanisms and therapeutic opportunities (Review) [0.03%]
铁死亡在骨科疾病中的作用：新兴机制和治疗机会（综述）
Wenhui Gu,Haifeng Zhang,Lisha Ye et al.
Wenhui Gu et al.
Ferroptosis, an iron‑dependent form of regulated cell death driven by lipid peroxidation, has emerged as a key mechanism underlying tissue degeneration and impaired regeneration in musculoskeletal disorders. Although ferroptosis is associa...
Dapagliflozin attenuates ferroptosis in diabetic nephropathy through activation of the Nrf2/HO‑1 signaling pathway [0.03%]
达格列净通过激活Nrf2/HO-1信号通路缓解糖尿病肾病的铁死亡
Hanshuang Liu,Xiaoxiao Zhang,Yubing Cui et al.
Hanshuang Liu et al.
Renal tubular injury has emerged as a critical determinant in the pathogenesis of diabetic nephropathy (DN). Ferroptosis, a recently characterized mode of iron‑dependent regulated cell death, has been implicated in the development of renal...
Advances in understanding the NLRP3 inflammasome‑mediated mechanisms and therapeutic targets in diabetic nephropathy (Review) [0.03%]
糖尿病肾病中NLRP3炎症小体介导的机制及治疗靶点的研究进展（英文）
Xiwei Wang,Shuang Li,Xiaotian Ge et al.
Xiwei Wang et al.
Diabetic nephropathy (DN), a severe microvascular complication of diabetes, has exhibited a steadily increasing global incidence and is a major contributor to diabetes‑related morbidity and mortality. DN is characterized by glomerular scle...