Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation [0.03%]
Wnt信号通过上调血小板型磷酸果糖激酶1促进肿瘤的发生与发展
So Mi Jeon,Je Sun Lim,Su Hwan Park et al.
So Mi Jeon et al.
The activation of Wnt signaling has been detected in various types of human cancer and has been shown to be associated with cancer development. In the present study, it was revealed that Wnt signaling induced the expression of phosphofructo...
Xiangling Chen,Fangfang Liu,Qingping Xue et al.
Xiangling Chen et al.
Pancreatic cancer (PC) is a lethal malignancy. Its prevalence rate remains low but continues to grow each year. Among all stages of PC, metastatic PC is defined as late‑stage (stage IV) PC and has an even higher fatality rate. Patients wit...
[Retracted] miR‑363 inhibits the growth, migration and invasion of hepatocellular carcinoma cells by regulating E2F3 [0.03%]
[撤回]:miR-363通过调节E2F3抑制肝癌细胞的生长、迁移和侵袭
Junfeng Ye,Wei Zhang,Songyang Liu et al.
Junfeng Ye et al.
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that tumour images featured in Fig. 2E were strikingly similar to those that had already appeared in different form in another article by ...
Retraction of Publication
Oncology reports. 2021 Nov;46(5):230. DOI:10.3892/or.2021.8181 2021
Lipidomic profiling reveals lipid regulation by a novel LSD1 inhibitor treatment [0.03%]
脂质组学分析揭示新型LSD1抑制剂治疗对脂质的调节作用
Yan Li,Xinying Qian,Yiyun Lin et al.
Yan Li et al.
Lipid metabolic alterations are associated with cancer progression. Lysine‑specific demethylase 1 (LSD1) plays a crucial role in cancer and has become a promising target for cancer therapy. However, the effect of LSD1 on lipid metabolism r...
Natural killer cell‑based immunotherapy for lung cancer: Challenges and perspectives (Review) [0.03%]
基于自然杀伤细胞的肺癌免疫治疗：挑战与展望（综述）
Yongqin Zeng,Xiuzhi Lv,Juan Du
Yongqin Zeng
Despite the marked success of molecular targeted therapy in lung cancer in this era of personalized medicine, its efficacy has been limited by the presence of resistance mechanisms. The prognosis of patients with lung cancer remains poor, a...
New insights from Whole Genome Sequencing: BCLAF1 deletion as a structural variant that predisposes cells towards cellular transformation [0.03%]
全基因组测序新见解：BCLAF1缺失是一种促使细胞转化的结构变异
Lamech M Mwapagha,Vimbaishe Chibanga,Hendrina Shipanga et al.
Lamech M Mwapagha et al.
Cancer arises from a multi‑step cellular transformation process where some mutations may be inherited, while others are acquired during the process of malignant transformation. Aberrations in the BCL2 associated transcription factor 1 (BCL...
Gallic acid enhances pirarubicin‑induced anticancer in living K562 and K562/Dox leukemia cancer cells through cellular energetic state impairment and P‑glycoprotein inhibition [0.03%]
没食子酸通过干扰细胞能量状态和抑制P-糖蛋白增强 pirarubicin 对 K562 和 K562/dox 神经胶质母细胞瘤癌细胞的抗肿瘤作用
Khin Thenu Aye,Sakornniya Wattanapongpitak,Benjamaporn Supawat et al.
Khin Thenu Aye et al.
Leukemia is a common malignancy affecting humans worldwide. Pirarubicin (Pira) is one of the anticancer agents used for the treatment of leukemia. Although Pira is effective, drug resistance may develop in cancer cells exposed to this drug,...
Uncovering the interplay between pH receptors and immune cells: Potential drug targets (Review) [0.03%]
pH受体与免疫细胞之间的相互作用：潜在的药物靶点（综述）
Lin Cao,Tianqiao Huang,Xiaohong Chen et al.
Lin Cao et al.
Extracellular acidosis is associated with various immunopathological states. The microenvironment of numerous solid tumours and inflammatory responses during acute or chronic infection are all related to a pH range of 5.5‑7.0. The relation...
Development of patient‑derived tumor organoids and a drug testing model for renal cell carcinoma [0.03%]
肾细胞癌的患者衍生肿瘤类器官及药物检测模型的研发
Akira Kazama,Tsutomu Anraku,Hiroo Kuroki et al.
Akira Kazama et al.
The selection of effective therapeutic agents is critical for improving the survival of patients with renal cell carcinoma (RCC). The aim of the present study was to develop an ex vivo drug testing assay using patient‑derived tumor organoi...
Chuan Xin,Fei Huang,Jiongke Wang et al.
Chuan Xin et al.
Circular RNA (circRNA) is a type of endogenous, high‑stability, noncoding RNA. circRNAs exhibit various biological functions, and are involved in physiological and pathological processes occurring in various diseases, including cancers. Th...