Identification of RRM2 as a key regulator of malignant epithelial cells in gastric cancer through single‑cell transcriptomics [0.03%]
通过单细胞转录组学鉴定RRM2作为胃癌恶性上皮细胞的关键调节因子
Xinzhen Cai,Yun He,Lili Kang et al.
Xinzhen Cai et al.
Gastric cancer (GC) is one of the most prevalent and life‑threatening malignancies of the digestive tract worldwide. Ribonucleotide reductase regulatory subunit M2 (RRM2), a rate‑limiting subunit in deoxyribonucleotide synthesis, is overe...
Impact of WFDC2 on the biological functions of cervical cancer cells and the regulation of the ERK/NF‑κB signaling pathway [0.03%]
WFDC2对宫颈癌细胞生物学功能的影响及对ERK/NF-κB信号通路的调控作用
Yanping Zhang,Hongling Zou,Shufeng Deng et al.
Yanping Zhang et al.
WAP four‑disulfide core domain 2 (WFDC2) may serve a notable regulatory role in cervical cancer, which is the most prevalent tumor of the female reproductive system. The present study aimed to investigate the function of WFDC2 in cervical ...
Schisandrin B exhibits anti‑proliferative effects by inducing ferroptosis in pancreatic cancer [0.03%]
schisandrin B通过诱导胰腺癌细胞铁死亡而发挥抗增殖作用
Fengjin Li,Jiacai Fu,Xiaowei Lin et al.
Fengjin Li et al.
Pancreatic cancer (PC) is a lethal malignant tumor of the digestive system with a low survival rate. Current therapies provide only modest benefits for patients and new therapeutic options are urgently needed. Schisandrin B (Sch B) has demo...
Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review) [0.03%]
DKK1在头颈鳞癌领域研究进展：从分子机制到临床应用（综述）
Xiaoqian Zhu,Liwei Hong,Weihan Chen et al.
Xiaoqian Zhu et al.
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies worldwide, characterized by persistently high and increasing rates of incidence, recurrence and mortality, thereby posing a considerable global public heal...
PI3Kδ inhibitor YY‑20394 is effective alone or in combination with Bcl‑2 inhibitor ABT199 in acute myeloid leukemia cells [0.03%]
PI3Kδ抑制剂YY‑20394在急性髓系白血病细胞中单药或与Bcl‑2抑制剂ABT199联用时有效
Yinghua Geng,Lili Zhou,Yan Lou et al.
Yinghua Geng et al.
YY‑20394 (linperlisib), a highly specific PI3Kδ inhibitor, has demonstrated promising efficacy in a variety of hematological malignancies in clinical trials. ABT199 (venetoclax) as a monotherapy shows limited effects in acute myeloid leuk...
A fibroblast activation protein degrader enhances cisplatin sensitivity in non‑small cell lung cancer [0.03%]
纤维活化蛋白降解剂可通过增强非小细胞肺癌对顺铂的敏感性发挥作用
Yong Zhou,Ranhua Li,Xiaobo Chen et al.
Yong Zhou et al.
The therapeutic effect of cisplatin against non‑small cell lung cancer (NSCLC), the most common lung cancer, is limited by resistance. In the present study, a fibroblast activation protein (FAP) degrader (Pomalidomide‑PEG2‑FAP2286: FAP‑...
Sterol regulatory element‑binding proteins: Master regulators of lipid metabolic reprogramming in cancer and emerging therapeutic targets (Review) [0.03%]
sterol调节元件结合蛋白：癌症中脂质代谢重组的主调控因子及新兴治疗靶点(综述)
Qing Liu,Rui Wang,Zhenbo Li et al.
Qing Liu et al.
Sterol regulatory element‑binding proteins (SREBPs) are key regulatory factors of lipid synthesis. Tumor cells are highly dependent on SREBP‑driven lipid synthesis for the biogenesis of their cell membranes and signaling molecules. The ab...
Dual targeting of mitochondrial metabolism and Rho GTPase signaling to suppress cancer metastasis (Review) [0.03%]
线粒体代谢和Rho GTP酶信号的双重抑制可降低癌症转移(综述)
Angelina Daher,Zahraa Assi,Amjad Kanaan et al.
Angelina Daher et al.
Despite the numerous advances in cancer therapy, disseminated neoplastic disease remains largely incurable and the primary cause of cancer‑related deaths. This process demands substantial bioenergetic and mechanical adaptability, orchestra...
[Expression of Concern] Antitumor activity of Notch‑1 inhibition in human colorectal carcinoma cells [0.03%]
[表达关注]诺特定点抑制在人类结直肠癌细胞中的抗肿瘤作用
Wangdi Liao,Guohua Li,Yu You et al.
Wangdi Liao et al.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that, regarding the cell morphology experiments shown in Fig. 4C and 9B on p. 1066 and p. 1069 respectively, the 'NC' data panel in Fig. 4...
Targeting colorectal cancer and T‑cell metabolism for the treatment of colorectal cancer (Review) [0.03%]
针对结直肠癌和T细胞代谢的结直肠癌治疗（综述）
Qiangzong Yu,Pengbo Luan,Jingru Liang et al.
Qiangzong Yu et al.
Colorectal cancer (CRC) is a malignant tumor of the digestive tract that is highly prevalent worldwide, which is associated with a poor prognosis in advanced stages and for which current treatment plans have limited efficacy. T cells serve ...