[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells [0.03%]
[BMI-1下调与CD44阳性鼻咽癌瘤细胞系肿瘤发生抑制及诱导凋亡相关][撤稿]
Xinhua Xu,Yang Liu,Jin Su et al.
Xinhua Xu et al.
Following the publication of the above article, a concerned reader drew to the Editor's attention that one set of the tumor data comparing between the 'CD44+' experiments in Fig. 4A and the 'CON' experiments in Fig. 4B on p. 428 had apparen...
Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review) [0.03%]
癌症药物耐药性中选择性剪接的机制及治疗前景（综述）
Wenpu Zhu,Zikun Wu,Chai Luv et al.
Wenpu Zhu et al.
Alternative splicing (AS) is one of the principal mechanisms of post‑transcriptional regulation that confers transcriptomic plasticity and proteomic diversity in cancer, thereby enabling tumor adaptation to therapeutic pressure. However, t...
Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma [0.03%]
胰腺导管腺癌肿瘤微环境中成纤维细胞衰老及其衰老相关分泌表型标志物的预后意义
Yuto Kitano,Tomoharu Miyashita,Takeo Shimasaki et al.
Yuto Kitano et al.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrous stroma, within which a subset of fibroblasts function as cancer‑associated fibroblasts (CAFs) and contribute to tumor progression. Some of these fibroblasts underg...
Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy [0.03%]
飞燕草素D通过抑制AKT/m TOR途径并与吉西他滨协同诱导胰腺癌细胞凋亡和自噬从而克服吉西他滨耐药性
Rui Zheng,Yusi Liu,Sen Zhou et al.
Rui Zheng et al.
Gemcitabine (GEM) is the first‑line chemotherapy drug for pancreatic cancer, but its efficacy is often limited by inherent drug resistance. Saikosaponin D (SSD), a bioactive triterpenoid saponin derived from the Bupleurum chinense root, ex...
Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review) [0.03%]
超越根除：癌症正常化治疗再编程策略（综述）
Aliasgar Shahiwala
Aliasgar Shahiwala
Cancer is increasingly recognized not as a fixed genetic condition but as a dynamic and plastic disease state driven by reversible epigenetic, transcriptional and microenvironmental cues. This evolving understanding supports a therapeutic p...
Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells [0.03%]
原发性纤毛发生抑制可增强EGFR-TKIS对非小细胞肺癌细胞的疗效
Liangliang Jin,Li Wei,Junrui Hua et al.
Liangliang Jin et al.
Primary cilia are antenna‑like organelles on almost all human cells that sense and transduce extracellular cues into cellular response. Primary cilia have been reported to be implicated in drug resistance in several cancer types, but their...
[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer [0.03%]
Sp1-CD147正反馈环促进卵巢癌侵袭能力被撤回：Sp1-CD147正反馈环促进卵巢癌侵袭能力
Jing Zhao,Wei Ye,Juan Wu et al.
Jing Zhao et al.
Subsequently to the publication of the above paper, a concerned reader has drawn to the Editor's attention that, for the western blot data shown in Fig. 2A and B on p. 71, certain of the protein bands looked strikingly similar to others, wh...
[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer [0.03%]
[表达关注]程序性细胞死亡蛋白激酶启动子甲基化及其在宫颈癌放疗反应中的作用
Rebecca Ching-Yu Leung,Stephanie Si Liu,Kelvin Yuen-Kwong Chan et al.
Rebecca Ching-Yu Leung et al.
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that the blots showing β‑actin mRNA expression in Fig. 1 on p. 1341 appeared to be similar to the β‑actin mRNA blots shown in Fig...
Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review) [0.03%]
铁死亡在癌症治疗中的作用及机制(综述)
Nabil Mouawad,Nour El Jaafari,Mirvat El Sibai et al.
Nabil Mouawad et al.
Ferroptosis is a type of programmed cell death characterized by accumulation of free iron, reactive oxygen species generation and lipid peroxidation and is distinct from other types of regulated cell deaths such as apoptosis, necrosis and a...
Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review) [0.03%]
SOX家族在非小细胞肺癌中的作用：分子机制和治疗意义(综述)
Kaiwei Wang,Yaoqi Li,Zhening Guo et al.
Kaiwei Wang et al.
Non‑small cell lung cancer (NSCLC), accounting for >85% of LC cases, remains a therapeutic challenge due to its low 5‑year survival rate, tumor heterogeneity and drug resistance. The SRY‑related high‑mobility group‑box (SOX) family com...