Ronald Neil Kostoff,Michael Brandon Briggs,Darja Kanduc et al.
Ronald Neil Kostoff et al.
The devastating complications of coronavirus disease 2019 (COVID‑19) result from the dysfunctional immune response of an individual following the initial severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection. Multiple to...
Expression of neurofibromin 1 in colorectal cancer and cetuximab resistance [0.03%]
结直肠癌和西妥昔单抗耐药性中的神经纤维蛋白1的表达
Eunyoung Tak,Minhee Kim,Youngra Cho et al.
Eunyoung Tak et al.
Neurofibromin 1 (NF1) is a tumor suppressor that has been previously reported to regulate RAS‑MAPK signaling. The present study investigated the possible relationship between NF1 expression and anti‑EGFR antibody (cetuximab) sensitivity i...
β‑glucan vaccine adjuvant approach for cancer treatment through immune enhancement (B‑VACCIEN) in specific immunocompromised populations (Review) [0.03%]
通过免疫增强进行癌症治疗的β-葡聚糖疫苗佐剂方法(B-VACCIEN)在特定免疫缺陷人群中的应用（评论）
Nobunao Ikewaki,Vidyasagar Devaprasad Dedeepiya,Kadalraja Raghavan et al.
Nobunao Ikewaki et al.
The incidence of cancer, which is the second leading cause of mortality globally, continues to increase, although continued efforts are being made to identify effective treatments with fewer side‑effects. Previous studies have reported tha...
Platelet isoform of phosphofructokinase accelerates malignant features in breast cancer [0.03%]
乳腺癌中血小板型磷酸果糖激酶加速恶性特征的表现
Takahiro Inaishi,Masahiro Shibata,Takahiro Ichikawa et al.
Takahiro Inaishi et al.
The platelet isoform of phosphofructokinase (PFKP) is one of the key enzymes in the glycolytic pathway. PFKP is highly expressed in several cancers, and it has been reported to be involved in the progression of cancer cells. However, its on...
PIK3CA mutation affects the proliferation of colorectal cancer cells through the PI3K-MEK/PDK1-GPT2 pathway [0.03%]
PIK3CA突变通过PI3K-MEK/PDK1-GPT2通路影响结直肠癌细胞的增殖
Wenli Chen,Guangli Dai,Yike Qian et al.
Wenli Chen et al.
The phosphatidylinositol‑3‑kinase catalytic subunit α (PIK3CA) gene is mutated in numerous human cancers. This mutation promotes the proliferation of tumor cells; however, the underlying mechanism is still not clear. In the present study...
KLF4, DAPK1 and SPG20 promoter methylation is not affected by DNMT1 silencing and hypomethylating drugs in lymphoma cells [0.03%]
KLF4，DAPK1和SPG20启动子甲基化不受淋巴瘤细胞中DNMT1沉默和低甲基化药物的影响
Raffaele Frazzi,Vincenza Ylenia Cusenza,Mariaelena Pistoni et al.
Raffaele Frazzi et al.
Promoter methylation represents one of the major epigenetic mechanisms responsible for the regulation of gene expression. Hypomethylating drugs are currently approved for the treatment of myelodysplastic syndromes and acute myeloid leukemia...
Diosmin in combination with naringenin enhances apoptosis in colon cancer cells [0.03%]
迪奥斯明与奈拉汀组合增强结肠癌细胞的凋亡作用
Bushra Zeya,Sana Nafees,Khalid Imtiyaz et al.
Bushra Zeya et al.
Colon cancer is one of the most commonly diagnosed malignancies, which begins as a polyp and grows to become cancer. Diosmin (DS) and naringenin (NR) are naturally occurring flavonoids that exhibit various pharmacological activities. Althou...
Androgen deprivation‑induced OPHN1 amplification promotes castration‑resistant prostate cancer [0.03%]
雄激素剥夺引起的OPHN1放大促进去势抵抗性前列腺癌的发展
Junjiang Liu,Yunxia Zhang,Shoubin Li et al.
Junjiang Liu et al.
Androgen deprivation therapy (ADT) is used to treat prostate cancer (PCa). However, ADT may increase the expression of androgen receptor (AR) through the amplification of chromosome X. The gene oligophrenin 1 (OPHN1) is located in the same ...
Glucose transporter‑1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells [0.03%]
葡萄糖转运体-1抑制克服了胃肠间质肿瘤细胞的伊马替尼耐药性
Takafumi Shima,Kohei Taniguchi,Yoshihisa Tokumaru et al.
Takafumi Shima et al.
Imatinib mesylate (imatinib) is the primary agent of choice used to treat gastrointestinal stromal tumors (GIST). However, drug resistance to imatinib poses a major obstacle to treatment efficacy. In addition, the relationship between imati...
Contrasting functions of the epithelial‑stromal interaction 1 gene, in human oral and lung squamous cell cancers [0.03%]
上皮基质相互作用1基因在人口腔和肺鳞状细胞癌中的不同功能
Mengmeng Fan,Makoto Arai,Akinobu Tawada et al.
Mengmeng Fan et al.
The epithelial‑stromal interaction 1 gene (EPSTI1) is known to play multiple roles in the malignant progression of breast cancer and also in some aspects of the immune responses to the tumor. However, the relevance of the gene in the onset...