Inhibitory role of angiopoietin‑like 4 for cancer progression in oropharyngeal squamous cell carcinoma [0.03%]
血管生成素样蛋白4在口腔咽部鳞状细胞癌中的抗肿瘤作用
Takuya Mikoshiba,Mariko Sekimizu,Nana Nakahara et al.
Takuya Mikoshiba et al.
The mortality rate of head and neck squamous cell carcinoma (HNSCC), one of the most prevalent types of cancer, has remained unchanged despite advances in treatment strategies. Angiopoietin‑like 4 (ANGPTL4) exhibits both pro‑ and anti‑tu...
Hypermethylation‑induced silencing of ITGA4 promotes oral squamous cell carcinoma progression through SNX5 upregulation [0.03%]
ITGA4高甲基化诱导沉默通过SNX5上调促进口腔鳞状细胞癌进展
Nguyen Ngoc Thuy Tien,Han-Cheol Choe,Sang-Gun Ahn
Nguyen Ngoc Thuy Tien
Epigenetic modifications, especially DNA methylation, play an increasingly important role in oral cancer. However, their specific contributions to the progression of oral squamous cell carcinoma (OSCC) remain unclear. The present study used...
[Expression of Concern] Pifithrin‑μ is efficacious against non‑small cell lung cancer via inhibition of heat shock protein 70 [0.03%]
[表达关注]Pifithrin-μ通过抑制热休克蛋白70有效治疗非小细胞肺癌
Yang Zhou,Jingping Ma,Jiahong Zhang et al.
Yang Zhou et al.
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that Fig. 6A on p. 320, showing the tumor volumes from the in vivo experiments, was lacking the units in the y‑axis, hence undermini...
Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway [0.03%]
MUC3A促进透明细胞肾细胞癌进展的JAK-STAT通路机制研究
Yongyang Yun,Xing Ji,Shuai Hu et al.
Yongyang Yun et al.
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and is associated with poor prognosis. The present study identified a membrane‑associated mucin, mucin 3A (MUC3A), a transmembrane glycoprotein, as a novel ...
[Expression of Concern] Adenovirus‑mediated truncated Bid overexpression induced by the Cre/LoxP system promotes the cell apoptosis of CD133+ ovarian cancer stem cells [0.03%]
表达关注：重组腺病毒载体系统在卵巢癌干细胞中诱导Bid蛋白截短片段过表达促进CD133+卵巣癌干细胞的凋亡
Qifang Long,Ru Yang,Weixian Lu et al.
Qifang Long et al.
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that a section of the western blot image for β‑actin in Fig. 1B on p. 157 had also been used for the control β‑actin blots in Fig...
Perturbation of BRD4 and p300 activity suppresses super enhancer‑driven KLF6 expression in renal carcinoma [0.03%]
BRD4和p300活性的扰动通过抑制肾癌中超级增强子驱动的KLF6表达发挥抑癌作用
Nurul Nadia Mohamad Zamberi,Asmaa Y Abuhamad,Siti Nur Hasanah Mohd Yusuf et al.
Nurul Nadia Mohamad Zamberi et al.
Super enhancers (SEs) are involved in regulating cell identity and lineage‑specific gene expression, and drive cancer‑associated gene expression. The transcription factor Kruppel‑like factor 6 (KLF6) promotes the growth and progression o...
Incorporating artificial intelligence into morphological diagnosis of acute leukemias: Current landscape, challenges and prospects (Review) [0.03%]
人工智能在急性白血病形态学诊断中的应用：现状、挑战与前景（综述）
Hui Cheng,Guodong Zheng,Yuanyuan Yang et al.
Hui Cheng et al.
Acute leukemias (ALs) are a diverse group of hematological malignancies characterized by the abnormal proliferation of immature cells. Microscopic observation of cell morphology based on the French‑American‑British classification remains ...
PINK1‑mediated mitophagy enhances breast cancer proliferation through metabolic reprogramming [0.03%]
PINK1介导的线粒体自噬通过代谢重编程促进乳腺癌增殖
Zong Jin Guo,Qian Yu,Rui Sha et al.
Zong Jin Guo et al.
Breast cancer is a predominant cause of cancer‑related mortality among women, particularly aggressive subtypes such as triple‑negative breast cancer (TNBC), which currently lack effective targeted therapies. While PTEN‑induced kinase 1 (...
NF‑κB‑driven LUZP1 promotes metastasis and chemoresistance in head and neck squamous cell carcinoma [0.03%]
NF-κB驱动的LUZP1促进头颈鳞状细胞癌的转移和化疗耐药性
Chen-Yuan Lin,Ching-Yun Hsieh,Hsin-Chi Lan et al.
Chen-Yuan Lin et al.
Head and neck squamous cell carcinoma (HNSCC) remains a highly aggressive malignancy with poor prognosis driven by metastasis and therapeutic resistance. Through comparative proteomic profiling of tumor specimens from patients with long‑ a...
[Expression of Concern] Metformin inhibits growth and sensitizes osteosarcoma cell lines to cisplatin through cell cycle modulation [0.03%]
[表达关切] 二甲双胍通过细胞周期调节抑制骨肉瘤细胞系增殖并增强其顺铂敏感性
Irene Quattrini,Amalia Conti,Laura Pazzaglia et al.
Irene Quattrini et al.
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the flow cytometric plots shown in Fig. 3 on p. 372, the C/U2OS and 48 h/U2OS, C/143B and 48 h/143B, and C/MG63 and 7...