HDAC1 promotes lung adenocarcinoma progression via the nuclear accumulation of β‑catenin [0.03%]
组蛋白脱乙酰酶1通过β‑连环素核积累促进肺腺癌进展
Shijie Xu,Xiaolu Chang,Xiayu Wu et al.
Shijie Xu et al.
Histone deacetylase 1 (HDAC1) is frequently dysregulated in various human malignancies; however, the molecular mechanisms underlying its role in non‑small cell lung cancer (NSCLC) remain unclear. HDAC1 expression was evaluated in 157 paire...
[Expression of Concern] Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways [0.03%]
[表达关注]通过ATP和caspase-3信号通路下调PTEN/AKT信号传导可降低人乳腺癌MCF-7细胞中TUBB3和TOP2A的表达，并随后抑制细胞生长并诱导细胞凋亡
Zhenhua Yang,Ying Liu,Changzheng Shi et al.
Zhenhua Yang et al.
Following the publication of the above article, a concerned author drew to the authors' attention that, regarding the data showing caspase-3 activity as measured by a colorimetric assay in Fig. 7 on p. 1015, given the use of the MCF‑7 cell...
Anticancer effects of tangeretin associated with reactive oxygen species generation, mitochondrial dysfunction and apoptosis in CaSki cells [0.03%]
观察CaSki细胞中诺橘素的抗癌作用及活性氧生成、线粒体功能障碍和细胞凋亡之间的关系
Seung-Hyeon Ahn,Zeeshan Ahmad Bhutta,Hwayoung Na et al.
Seung-Hyeon Ahn et al.
Cervical cancer is the fourth most common cancer and the fourth leading cause of cancer‑related mortality among women worldwide. Tangeretin (TAN), a polymethoxylated flavonoid derived from citrus fruit peel, exhibits relatively high struct...
[Retracted] MicroRNA‑365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3 [0.03%]
微RNA-365通过靶向PIK3R3抑制胶质瘤的增殖、迁移和侵袭（已撤稿）
Yonggang Zhu,Hongguang Zhao,Min Rao et al.
Yonggang Zhu et al.
Following the publication of the above article, a concerned reader drew to the Editor's attention that western blot data featured in Fig. 5D were apparently the same as those featured in a different research article by the same group in the...
Ying Zhao,Li Han,Qingyu Wu et al.
Ying Zhao et al.
The tumor immune microenvironment (TIME) is the key determinant of limited efficacy and acquired resistance to cancer immunotherapy across human malignancies. In this context, connective tissue growth factor (CTGF) has been implicated in mu...
Multidimensional molecular mechanisms of drug resistance in breast cancer: Implications for clinical decision‑making and treatment strategies (Review) [0.03%]
乳腺癌药物耐药的多维度分子机制：对临床决策和治疗策略的影响(综述)
Wenya Xu,Shiyao Kang,Shaochen Xin et al.
Wenya Xu et al.
Breast cancer has the highest incidence among malignant tumors in women worldwide. Although targeted therapy, chemotherapy, and endocrine therapy have achieved significant efficacy, acquired resistance remains a major challenge affecting pa...
Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and suppressing Wnt/β‑catenin signaling [0.03%]
聚药碱Ⅱ通过靶向HRH1和抑制Wnt/β-catenin信号传导来抑制甲状腺癌进展
Jianwei Sun,Haifeng Liang,Yan Zhang et al.
Jianwei Sun et al.
Polyphyllin II, a natural steroidal saponin extracted from Paris polyphylla, exhibits potent antitumor activity in thyroid cancer. In the present study, bioinformatics analysis, molecular docking, Drug Affinity Responsive Target Stability a...
M2‑TAM‑derived exosomal miR‑491‑3p modulates UBE2D3 and promotes the proliferation, migration and invasion of lung cancer cells [0.03%]
M2-TAM源外泌体miR-491-3p通过调控UBE2D3促进肺癌细胞增殖、迁移和侵袭
Qiang Zhang,Yungang Sun,Yu Zhuang et al.
Qiang Zhang et al.
M2 tumor‑associated macrophages (M2‑TAMs) have been reported to promote tumor growth through exosome‑dependent mechanisms. However, the exact role of exosomes derived from M2‑TAMs (M2‑TAM‑Exos) in lung cancer progression remains uncle...
Stable overexpression of Nup88 enhances HeLa cell migration through independent regulation of Kif7 and Gli1 [0.03%]
Nup88的稳定过表达通过独立调控Kif7和Gli1增强HEK293T细胞迁移能力
Masaki Makise,Ryota Uchimura,Ayano Shiraishi et al.
Masaki Makise et al.
Elevated expression of nucleoporin (Nup) 88 is often observed in various types of cancer and correlates with tumor grade. However, the underlying molecular mechanism by which Nup88 induces cancer malignancy remains unclear. The present stud...
TPD54 contributes to docetaxel resistance through modulation of P‑glycoprotein localization and activity in oral squamous cell carcinoma cells [0.03%]
TPD54通过调节P-糖蛋白定位和活性介导-docetaxel耐药在口腔鳞状细胞系中
Maki Nara,Yoshiki Mukudai,Masataka Watanabe et al.
Maki Nara et al.
Tumor protein D52 (TPD52) family proteins are involved in the proliferation, survival and malignant progression of oral squamous cell carcinoma (OSCC). However, their roles in chemoresistance remain incompletely understood. The present stud...