Circ_0000620 acts as an oncogenic factor in gastric cancer through regulating MMP2 expression via sponging miR-671-5p [0.03%]
circ_0000620通过海绵吸附miR-671-5p调控MMP2表达在胃癌中起致癌作用
Junyu Ren,Guoqing Pan,Jun Yang et al.
Junyu Ren et al.
Background: Gastric cancer (GC) is one of the most common cancers in the digestive system. Circular RNAs (circRNAs) have been found to function as important regulators in the pathogenesis of GC. This study focused on the ...
A potential hypothesis for 2019-nCoV infection therapy through delivery of recombinant ACE2 by red blood cell-hitchhiking [0.03%]
红细胞附生递送重组ACE2治疗2019-nCoV感染的潜在方案
Zahra Sadat Aghili,Seyed Abbas Mirzaei,Mehdi Banitalebi-Dehkordi
Zahra Sadat Aghili
A novel infectious disease, caused by 2019 Novel Coronavirus (2019-nCoV) is responsible for the recent outbreak of severe respiratory disease. The 2019-nCoV spread rapidly and reaching epidemic proportions in many countries of the world. AC...
Peroxiredoxin-6 regulates p38-mediated epithelial-mesenchymal transition in HCT116 colon cancer cells [0.03%]
过氧化还原素6调节HCT116结肠癌细胞中p38介导的上皮间充质转化
Unbin Chae,Bokyung Kim,HanSeop Kim et al.
Unbin Chae et al.
Background: Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress induced by several factors. They regulate several signaling pathways, such as metabolism, immune response, and intracellul...
Nesfatin-1 protects H9c2 cardiomyocytes against cobalt chloride-induced hypoxic injury by modulating the MAPK and Notch1 signaling pathways [0.03%]
Nesfatin-1通过调节MAPK和Notch1信号通路保护H9c2心肌细胞免受氯化钴诱导的缺氧损伤
Mingchen Li,Kai Li,Yuan Ren
Mingchen Li
Background: This study aimed to explore the effect of nesfatin-1 on cobalt chloride (CoCl2)-induced hypoxic injury in cardiomyocyte H9c2 cells. Methods: ...
LncRNA FBXL19-AS1 promotes proliferation and metastasis of cervical cancer through upregulating COL1A1 as a sponge of miR-193a-5p [0.03%]
长链非编码RNA FBXL19-AS1通过作为miR-193a-5p的海绵上调COL1A1促进宫颈癌的增殖和转移
Xiaoyong Huang,Haiyan Shi,Xinghai Shi et al.
Xiaoyong Huang et al.
Background: Cervical cancer (CC) is one of the most common and malignant tumors in women. In this study, we aim to explore the role and mechanism of F-box and leucine rich repeat protein 19 antisense RNA 1 (FBXL19-AS1), a...
CircCNIH4 inhibits gastric cancer progression via regulating DKK2 and FRZB expression and Wnt/β-catenin pathway [0.03%]
Circular RNA CNIH4通过调节DKK2和FRZB表达及Wnt/β-catenin信号通路抑制胃癌进展
Qi Shi,Chuanwen Zhou,Rui Xie et al.
Qi Shi et al.
Background: Circular RNAs (circRNAs) have been reported to play an important role in tumor progression in various cancer types, including gastric cancer. The aim of this study was to investigate the role of circCNIH4 (hsa...
Callose: a multifunctional (1, 3)-β-D-glucan involved in morphogenesis and function of angiosperm stomata [0.03%]
胼胝素：参与被子植物气孔形态生成和功能的(1, 3)-β-D-葡萄糖聚多糖体
Panagiotis Apostolakos,Eleni Giannoutsou,Basil Galatis
Panagiotis Apostolakos
Background: Although the cellulose microfibril organization in guard cell (GC) walls play a crucial role in the mechanism of the stomatal function, recent work showed that matrix cell wall materials are also involved. Esp...
Predicted antiviral drugs Darunavir, Amprenavir, Rimantadine and Saquinavir can potentially bind to neutralize SARS-CoV-2 conserved proteins [0.03%]
预测的抗病毒药物达芦那韦、安普那韦、利曼纽明和沙奎那韦可以潜在结合中和冠状病毒系保守蛋白
Umesh C Halder
Umesh C Halder
Background: Novel Coronavirus disease 2019 or COVID-19 has become a threat to human society due to fast spreading and increasing mortality. It uses vertebrate hosts and presently deploys humans. Life cycle and pathogenici...
PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients' RBCs ex vivo in the frame of Protein Replacement Therapy [0.03%]
基于蛋白质替代疗法框架的PTD介导α珠蛋白链进入K-562红白血病细胞和β+-地中海贫血患者红细胞的体外实验研究
Androulla N Miliotou,Dionysia Papagiannopoulou,Efthymia Vlachaki et al.
Androulla N Miliotou et al.
Background: α-Thalassemia, a congenital hemoglobinopathy, is characterized by deficiency and/or reduced levels of α-globin chains in serious forms of α-thalassemia (HbH disease/Hb Bart's). This research work deals with...
Relationship between the structure and function of the transcriptional regulator E2A [0.03%]
转录调节因子E2A的结构与功能的关系研究
Jia-Jie Liang,Hu Peng,Jiao-Jiao Wang et al.
Jia-Jie Liang et al.
E proteins are transcriptional regulators that regulate many developmental processes in animals and lymphocytosis and leukemia in Homo sapiens. In particular, E2A, a member of the E protein family, plays a major role in the transcriptional ...