Multicomponent crystalline solid forms of aripiprazole produced via hot melt extrusion techniques: An exploratory study [0.03%]
利培酮多组分晶型固体制剂的热熔挤出制备工艺探索性研究
Arun Butreddy,Mashan Almutairi,Neeraja Komanduri et al.
Arun Butreddy et al.
Multicomponent crystalline solid forms (salts, cocrystals and eutectics) are a promising means of enhancing the dissolution behavior of poorly soluble drugs. The present study demonstrates the development of multicomponent solid forms of ar...
Theophylline-nicotinamide pharmaceutical co-crystals generated using hot melt extrusion technology: Impact of polymeric carriers on processability [0.03%]
采用熔融挤出技术生成的茶碱-烟胺药物共晶：高分子载体制备对加工性能的影响研究
Priyanka Srinivasan,Mashan Almutairi,Nagireddy Dumpa et al.
Priyanka Srinivasan et al.
The objective of the current study was to develop theophylline (TPH) nicotinamide (NAM) pharmaceutical co-crystals using the hot melt extrusion (HME) technology and evaluate the processability of the co-crystals using different polymeric ca...
Pharmaceutical Co-Crystals, Salts, and Co-Amorphous Systems: A Novel Opportunity of Hot Melt Extrusion [0.03%]
药物共晶、盐和共非晶体系：熔融挤出的新机遇
Sagar Narala,Dinesh Nyavanandi,Priyanka Srinivasan et al.
Sagar Narala et al.
Enhancing the solubility of active drug ingredients is a major challenge faced by scientists and researchers. Different approaches have been explored for the enhancement of solubility and physicochemical properties of drugs, without affecti...
The pulmonary route as a way to drug repositioning in COVID-19 therapy [0.03%]
肺部途径作为COVID-19治疗中老药新用的方法
Michelle Alvares Sarcinelli,Thalita Martins da Silva,Andressa Daniele Artico Silva et al.
Michelle Alvares Sarcinelli et al.
Introduction: The outbreak of the disease caused by the new coronavirus (COVID-19) has been affecting society's routine and its patterns of interaction worldwide, in addition to the impact on the global economy. To date, ...
Recent updates in COVID-19 with emphasis on inhalation therapeutics: Nanostructured and targeting systems [0.03%]
近期关于冠状病毒肺炎的进展，着重吸入治疗：纳米结构及靶向系统
Ahmed A H Abdellatif,Hesham M Tawfeek,Ahmed Abdelfattah et al.
Ahmed A H Abdellatif et al.
The current world health threat posed by the novel coronavirus disease of 2019 (COVID-19) calls for the urgent development of effective therapeutic options. COVID-19 needs daunting routes such as nano-antivirals. Hence, the role of nanotech...
Juliana Rincón-López,Yara C Almanza-Arjona,Alejandro P Riascos et al.
Juliana Rincón-López et al.
We herein disclose how global cyclodextrin-based pharmaceutical technologies have evolved since the early 80s through a 1998 patents dataset retrieved from Derwent Innovation Index. We used text-mining techniques based on the patents semant...
Can human overcome viral hijack-? Comprehensive review on COVID-19 in the view of diagnosis and mitigation across countries [0.03%]
人类能否克服病毒的劫持？从诊断和缓解角度看COVID-19的全面回顾各国情况
Maheswari Nagendran,Juliana John,Kavithakani Annamalai et al.
Maheswari Nagendran et al.
The novel COVID-19, a pandemic disease, is showing an alarming spread and severity throughout the world. Globally, the community transmission of this disease is affecting people in large clusters and so it is necessary to mitigate and contr...
A pH sensitive thiolated β-cyclodextrin-modified nanoporous gold for controlled release of doxorubicin [0.03%]
具有酸敏感性的含硫修饰纳米多孔金的可控阿霉素释放研究
Dharmendra Neupane,Jay K Bhattarai,Alexei V Demchenko et al.
Dharmendra Neupane et al.
This article reports a novel thiolated β-cyclodextrin (HS-β-CD) modified nanoporous gold (NPG) wire for pH sensitive delivery of doxorubicin (DOX) in controlled manner. Nanoporous gold is a versatile material because of its three-dimensio...
Stable amorphous solid dispersions of fenofibrate using hot melt extrusion technology: Effect of formulation and process parameters for a low glass transition temperature drug [0.03%]
采用热熔挤出技术制备稳定的非晶fenofibrate固体分散体：低玻璃化转变温度药物的配方和工艺参数的影响
Venkata Raman Kallakunta,Sandeep Sarabu,Suresh Bandari et al.
Venkata Raman Kallakunta et al.
Development of stable amorphous solid dispersions (ASDs) for a low glass transition temperature (Tg) drug is a challenging task. The physico-chemical properties of the drug and excipients play a critical role in developing stable ASDs. In t...
Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition [0.03%]
聚乙烯吡咯烷酮(PVP)的药学评价：从常规到控制释放系统作为赋形剂，并重点关注COVID-19抑制作用
Mallesh Kurakula,G S N Koteswara Rao
Mallesh Kurakula
Polyvinylpyrrolidone (PVP) is a water-soluble polymer obtained by polymerization of monomer N-vinylpyrrolidone. PVP is an inert, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and...